PMID- 36158787
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Association of endothelial glycocalyx shedding and coronary microcirculation 
      assessed by an angiography-derived index of microcirculatory resistance in 
      patients with suspected coronary artery disease.
PG  - 950102
LID - 10.3389/fcvm.2022.950102 [doi]
LID - 950102
AB  - BACKGROUND: The endothelial glycocalyx (EG) is essential for maintaining 
      microvascular homeostasis. However, the relationship between the EG and coronary 
      microcirculation remains to be elucidated. One of the main components of EG is 
      syndecan-1, and its shedding has been claimed to represent the state of the EG. 
      In this study, we aimed to analyze the association between syndecan-1 and the 
      coronary microcirculation. METHODS: We enrolled suspected coronary artery disease 
      (CAD) patients who consecutively underwent coronary angiography (CAG) and 
      angiography-based analysis of physiological indices in the left anterior 
      descending artery (LAD). Serum syndecan-1 was measured by enzyme-linked 
      immunosorbent assay (ELISA). The coronary microcirculation was evaluated by the 
      presence of coronary microvascular dysfunction (CMD) and an impaired 
      microvascular vasodilatory capacity (IMVC), which were quantified by an 
      angiography-derived index of microcirculatory resistance (IMRangio) in the 
      maximum hyperemic state (H-IMRangio) induced by adenosine triphosphate and the 
      ratio (RRRangio) of IMRangio in the non-hyperemic phase to H-IMRangio, 
      respectively. RESULTS: A total of 528 patients were enrolled in this study. There 
      was no difference in epicardial coronary complexity between patients with high 
      syndecan-1 (HSG) and low syndecan-1 (LSG) levels grouped by the median 
      concentration of syndecan-1 (SYNTAX: 7[3, 10] vs. 9[4, 12], P = 0.15). However, 
      H-IMRangio and RRRangio were different between the LSG and HSG groups 
      (H-IMRangio: 23.64 +/- 6.28 vs. 27.67 +/- 5.59, P < 0.01; RRRangio: 1.74[1.46, 2.08] 
      vs. 1.55[1.34, 1.72], P < 0.01). Patients with CMD (H-IMRangio > 25) and patients 
      with IMVC (RRRangio below the median value) both had higher syndecan-1 levels 
      (CMD: 86.44 +/- 54.15 vs. 55.2 +/- 43.72, P < 0.01; IMVC: 83.86 +/- 55.41 vs. 59.68 +/- 
      45.06, P < 0.01). After adjustment for confounding factors, HSG remained 
      associated with the presence of CMD and IMVC (CMD: odds ratio [OR]: 2.769, P < 
      0.01; IMVC: OR: 1.908, P < 0.01). CONCLUSION: High levels of syndecan-1 are 
      independently associated with the presence of CMD and IMVC among patients with 
      suspected CAD.
CI  - Copyright (c) 2022 Liu, Chen, Liu, Sun, Sun and Liu.
FAU - Liu, Yang
AU  - Liu Y
AD  - Medical School of Chinese People's Liberation Army, Beijing, China.
AD  - Department of Cardiology, Second Medical Center of Chinese People's Liberation 
      Army General Hospital, Beijing, China.
AD  - National Clinical Research Center for Geriatric Diseases, Beijing, China.
FAU - Chen, Si
AU  - Chen S
AD  - Department of Cardiology, First Medical Center of Chinese People's Liberation 
      Army General Hospital, Beijing, China.
FAU - Liu, Shaoyan
AU  - Liu S
AD  - Department of Cardiology, Yantai Municipal Laiyang Central Hospital, Yantai, 
      China.
FAU - Sun, Guoqiang
AU  - Sun G
AD  - Department of Cardiology, Sixth Medical Center of Chinese People's Liberation 
      Army General Hospital, Beijing, China.
FAU - Sun, Zhijun
AU  - Sun Z
AD  - Department of Cardiology, Sixth Medical Center of Chinese People's Liberation 
      Army General Hospital, Beijing, China.
FAU - Liu, Hongbin
AU  - Liu H
AD  - Medical School of Chinese People's Liberation Army, Beijing, China.
AD  - Department of Cardiology, Second Medical Center of Chinese People's Liberation 
      Army General Hospital, Beijing, China.
AD  - National Clinical Research Center for Geriatric Diseases, Beijing, China.
AD  - Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, Beijing, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220908
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9493183
OTO - NOTNLM
OT  - angiography-derived index of microcirculatory resistance
OT  - coronary microcirculation
OT  - coronary microvascular dysfunction
OT  - endothelial glycocalyx
OT  - impaired microvascular vasodilatory capacity
OT  - syndecan-1
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2022/09/08
CRDT- 2022/09/26 17:26
PHST- 2022/05/22 00:00 [received]
PHST- 2022/08/23 00:00 [accepted]
PHST- 2022/09/26 17:26 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2022/09/08 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.950102 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Sep 8;9:950102. doi: 10.3389/fcvm.2022.950102. 
      eCollection 2022.