PMID- 36158818
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - The guiding value of hybrid resting full-cycle ratio and fractional flow reserve 
      strategy for percutaneous coronary intervention in a Chinese real-world cohort 
      with non-ST elevation acute coronary syndrome.
PG  - 991161
LID - 10.3389/fcvm.2022.991161 [doi]
LID - 991161
AB  - OBJECTIVE: The study aimed to assess the correlation and agreement between 
      resting full-cycle ratio (RFR) and fractional flow reserve (FFR), and evaluate 
      the guiding value of a hybrid RFR-FFR strategy for percutaneous coronary 
      intervention (PCI) in a Chinese real-world cohort with non-ST elevation acute 
      coronary syndrome (NSTE-ACS). MATERIALS AND METHODS: A total of 109 patients with 
      NSTE-ACS (149 diseased vessels), who underwent an invasive physiological 
      assessment in Cangzhou Central Hospital, Hebei Medical University, were 
      prospectively enrolled from September 2021 to May 2022. FFR </= 0.80 was used as 
      the gold standard for coronary artery functional ischemia. We utilized the 
      Pearson correlation and Bland-Altman analysis to assess the correlation and 
      agreement between RFR and FFR. The diagnostic value of RFR predicting FFR </= 0.80 
      was evaluated in accordance with the receiver operating characteristic (ROC) 
      curve. The hybrid RFR-FFR strategy, which was established according to 
      determining the "gray zone" of RFR (FFR was further assessed using vasodilators 
      only for diseased vessels in the "gray zone"), needed to afford over 95% global 
      agreement with the FFR-only strategy. RESULTS: Resting full-cycle ratio was 
      significantly linearly linked with FFR (R (2) = 0.636, P < 0.001). The accuracy, 
      specificity, and sensitivity for RFR </= 0.89 predicting FFR </= 0.80 were 81.2, 
      70.8, and 86.1%, respectively. The area under the ROC curve for RFR predicting 
      FFR </= 0.80 was 0.881 (P < 0.001), and the cutoff value was 0.90. The "gray zone" 
      of RFR was 0.85-0.93. The positive and negative predictive values of the hybrid 
      RFR-FFR strategy were 0.95 and 0.93, respectively. The hybrid RFR-FFR strategy 
      exhibited an agreement of 96.0% with FFR and obviated the need for a vasodilator 
      by 60.4%. CONCLUSION: Resting full-cycle ratio and FFR have high correlation and 
      consistency. The hybrid RFR-FFR strategy highlights considerably enhanced 
      agreement with the FFR-only strategy, whilst making the requirement of 
      vasodilator administration less than a half.
CI  - Copyright (c) 2022 Lei, Zhang, Li, Wang, Wang, Zhao, Yan, Chen, Su, Yu, Yu, Dong, 
      Cao and Yan.
FAU - Lei, Yumeng
AU  - Lei Y
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Zhang, Shuaiyong
AU  - Zhang S
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Li, Mengyao
AU  - Li M
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Wang, Jiawang
AU  - Wang J
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Wang, Yunfei
AU  - Wang Y
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Yan, Wei
AU  - Yan W
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Chen, Ming
AU  - Chen M
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Su, Yanjie
AU  - Su Y
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Yu, Jing
AU  - Yu J
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Yu, Na
AU  - Yu N
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Dong, Tongjun
AU  - Dong T
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Cao, Xufen
AU  - Cao X
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
FAU - Yan, Liqiu
AU  - Yan L
AD  - Department of Cardiology, Cangzhou Central Hospital, Hebei Medical University, 
      Cangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220907
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9505915
OTO - NOTNLM
OT  - fractional flow reserve
OT  - hybrid RFR-FFR strategy
OT  - non-ST elevation acute coronary syndromes
OT  - percutaneous coronary intervention
OT  - resting full-cycle ratio
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2022/09/07
CRDT- 2022/09/26 17:26
PHST- 2022/07/29 00:00 [received]
PHST- 2022/08/23 00:00 [accepted]
PHST- 2022/09/26 17:26 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2022/09/07 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.991161 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Sep 7;9:991161. doi: 10.3389/fcvm.2022.991161. 
      eCollection 2022.