PMID- 36158972
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Neurological mechanism and treatment effects prediction of acupuncture on 
      migraine without aura: Study protocol for a randomized controlled trial.
PG  - 981752
LID - 10.3389/fneur.2022.981752 [doi]
LID - 981752
AB  - INTRODUCTION: Acupuncture is an effective treatment in migraine without aura 
      (MWoA), but the neurological mechanism has not been investigated using multimodal 
      magnetic resonance imaging (MRI). This trial will combine functional MRI, 
      structural MRI, and diffusion tensor imaging to explore the potential neural 
      mechanism of acupuncture on MWoA, and will use machine learning approach to 
      predict acupuncture treatment effects. METHODS: In this multimodal neuroimaging 
      randomized controlled trial, a total of 60 MWoA participants will be randomly 
      allocated to two groups: the real acupuncture treatment group and the sham 
      acupuncture control group. This trial will include a 4-week baseline phase, a 
      4-week treatment phase, and a 12-week follow-up phase. Participants will undergo 
      12 acupuncture or sham acupuncture sessions during the treatment phase. The 
      Headache Diary, Migraine-Specific Quality of Life Questionnaire, Headache Impact 
      Test, Beck Depression Inventory-II, and Beck Anxiety Inventory will be utilized 
      to evaluate the clinical efficacy. Multimodal MRI scans will be employed to 
      investigate the mechanism of acupuncture at baseline, at the end of treatment, 
      and after follow-up. Multimodal MRI data will be used to predict acupuncture 
      treatment effects using machine learning technology. DISCUSSION: This study 
      hypothesized that acupuncture therapy may treat MWoA by restoring the 
      neuropathological alterations in brain activity. Our finding should provide 
      valuable scientific proof for the effects of acupuncture and demonstrate the 
      usefulness of acupuncture in the treatment of MWoA. Moreover, acupuncture 
      response prediction might decrease healthcare expenses and time lags for 
      patients. TRIAL REGISTRATION NUMBER: [ChiCTR2100044251].
CI  - Copyright (c) 2022 Hong, Sun, Zhang, Tan, Chen, Chen, Zhu, Liu, Zhu, Zeng, Kong, Li 
      and Liu.
FAU - Hong, Jiahui
AU  - Hong J
AD  - School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, 
      China.
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Sun, Jingqing
AU  - Sun J
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Zhang, Liping
AU  - Zhang L
AD  - Department of Radiology, Dong Zhimen Hospital Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Tan, Zhongjian
AU  - Tan Z
AD  - Department of Radiology, Dong Zhimen Hospital Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Chen, Ying
AU  - Chen Y
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Chen, Qiuyi
AU  - Chen Q
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Zhu, Yupu
AU  - Zhu Y
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Liu, Yuhan
AU  - Liu Y
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Zhu, Liying
AU  - Zhu L
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Zeng, Lin
AU  - Zeng L
AD  - Peking University Third Hospital, Research Centre of Clinical Epidemiology, 
      Beijing, China.
FAU - Kong, Yazhuo
AU  - Kong Y
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional 
      Chinese Medicine, Capital Medical University, Beijing Key Laboratory of 
      Acupuncture Neuromodulation, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220908
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9492888
OTO - NOTNLM
OT  - acupuncture
OT  - clinical trial
OT  - migraine without aura
OT  - multimodal magnetic resonance imaging
OT  - neurological mechanism
OT  - protocol
OT  - treatment effects prediction
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2022/09/08
CRDT- 2022/09/26 17:29
PHST- 2022/06/29 00:00 [received]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/26 17:29 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2022/09/08 00:00 [pmc-release]
AID - 10.3389/fneur.2022.981752 [doi]
PST - epublish
SO  - Front Neurol. 2022 Sep 8;13:981752. doi: 10.3389/fneur.2022.981752. eCollection 
      2022.