PMID- 36159247
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20230123
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 10
DP  - 2022
TI  - Association between environmental lead/cadmium co-exposure in drinking water and 
      soil and type 2 diabetes mellitus/obesity in Southern China.
PG  - 941922
LID - 10.3389/fpubh.2022.941922 [doi]
LID - 941922
AB  - Lead (Pb) and cadmium (Cd) in environment can be directly absorbed by drinking 
      water and soil. However, data on human Pb and Cd exposure by drinking water and 
      soil and its long-term consequence for type 2 diabetes mellitus (T2DM) and 
      obesity are lacking. Our study aims to explore the association of typical heavy 
      metals co-exposure in drinking water and soil to the community residents with 
      T2DM and obesity indices in two cities of southern China. A cross-sectional study 
      enrolling total 1,274 participants was performed and the local water and soil 
      samples were collected in two communities in southern China. The average daily 
      dose (ADD) of heavy metals was calculated to assess the exposure. The obesity 
      indices comprise body mass index (BMI), waist-to-hip ratio (WHR) and waist 
      circumference (WC). Binary, multiple logistic and linear regressions were 
      employed for assessing the associations of Pb and Cd exposure with T2DM and 
      obesity. The results showed that there weren't any significant correlations 
      between ADDs of Pb/Cd and T2DM in community residents (all Ps>0.05). Compared 
      with those with 18.5 </= BMI <24, with 1 mug/kg bw/d ADD of Pb increase in exposure 
      are associated with 49.2-56.1% lower likelihood of overweight. Besides, with ADDs 
      of Pb exposure was increased by 1 mug/kg bw/d and WHR decreasing by 0.01-0.02, and 
      WC decreasing by 2.22-4.67 cm. We speculate that Pb causes weight loss because it 
      damages the absorption function of the gastrointestinal tract as an initial 
      injury. 1mug/kg bw/d ADD of Cd increase is associated with 100.9% upper likelihood 
      of low weight in Model 1. It suggests that Pb/Cd pollution in the local 
      environment was serious and harmful to residents' health. Government should 
      introduce relevant oversight and accountability systems to improve the prevention 
      and management of lifestyle-related chronic diseases in the future.
CI  - Copyright (c) 2022 Qu, Zhou, Guo, Wang, Wang, Liu, Wu, Wang and Liu.
FAU - Qu, Zhi
AU  - Qu Z
AD  - School of Nursing, Institute of Chronic Disease Risks Assessment, Henan 
      University, Kaifeng, China.
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
FAU - Zhou, Jianli
AU  - Zhou J
AD  - School of Nursing, Institute of Chronic Disease Risks Assessment, Henan 
      University, Kaifeng, China.
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
FAU - Guo, Peisen
AU  - Guo P
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
FAU - Wang, Jingrui
AU  - Wang J
AD  - School of Nursing, Institute of Chronic Disease Risks Assessment, Henan 
      University, Kaifeng, China.
FAU - Wang, Panpan
AU  - Wang P
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
FAU - Liu, Limin
AU  - Liu L
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
FAU - Wu, Mengdi
AU  - Wu M
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
FAU - Wang, Peixi
AU  - Wang P
AD  - School of Nursing, Institute of Chronic Disease Risks Assessment, Henan 
      University, Kaifeng, China.
FAU - Liu, Nan
AU  - Liu N
AD  - School of Nursing, Institute of Chronic Disease Risks Assessment, Henan 
      University, Kaifeng, China.
AD  - Health Science Center, Institute of Environment and Health, South China Hospital, 
      Shenzhen University, Shenzhen, China.
AD  - College of Public Health, Zhengzhou University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220907
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - 0 (Drinking Water)
RN  - 0 (Metals, Heavy)
RN  - 0 (Soil)
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Cadmium/analysis
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Drinking Water
MH  - Humans
MH  - Lead
MH  - *Metals, Heavy/analysis
MH  - Obesity/epidemiology
MH  - Soil
PMC - PMC9489910
OTO - NOTNLM
OT  - average daily dose
OT  - cadmium
OT  - lead
OT  - obesity
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/09/07
CRDT- 2022/09/26 17:33
PHST- 2022/05/12 00:00 [received]
PHST- 2022/08/19 00:00 [accepted]
PHST- 2022/09/26 17:33 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/09/07 00:00 [pmc-release]
AID - 10.3389/fpubh.2022.941922 [doi]
PST - epublish
SO  - Front Public Health. 2022 Sep 7;10:941922. doi: 10.3389/fpubh.2022.941922. 
      eCollection 2022.