PMID- 36160158
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Langerin-expressing dendritic cells in pulmonary immune-related diseases.
PG  - 909057
LID - 10.3389/fmed.2022.909057 [doi]
LID - 909057
AB  - Dendritic cells (DCs) are "frontline" immune cells dedicated to antigen 
      presentation. They serve as an important bridge connecting innate and adaptive 
      immunity, and express various receptors for antigen capture. DCs are divided into 
      various subclasses according to their differential expression of cell surface 
      receptors and different subclasses of DCs exhibit specific immunological 
      characteristics. Exploring the common features of each sub-category has became 
      the focus of many studies. There are certain amounts of DCs expressing langerin 
      in airways and peripheral lungs while the precise mechanism by which langerin(+) 
      DCs drive pulmonary disease is unclear. Langerin-expressing DCs can be further 
      subdivided into numerous subtypes based on the co-expressed receptors, but here, 
      we identify commonalities across these subtypes that point to the major role of 
      langerin. Better understanding is required to clarify key disease pathways and 
      determine potential new therapeutic approaches.
CI  - Copyright (c) 2022 Xuan, Li, Wu, Adcock, Zeng and Yao.
FAU - Xuan, Shurui
AU  - Xuan S
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
FAU - Li, Yuebei
AU  - Li Y
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
FAU - Wu, Yunhui
AU  - Wu Y
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
FAU - Adcock, Ian M
AU  - Adcock IM
AD  - Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, 
      Imperial College London, London, United Kingdom.
FAU - Zeng, Xiaoning
AU  - Zeng X
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
FAU - Yao, Xin
AU  - Yao X
AD  - Department of Respiratory and Critical Care Medicine, The First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220907
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9490018
OTO - NOTNLM
OT  - dendritic cells
OT  - immunity
OT  - langerin
OT  - pathogenesis
OT  - pulmonary immune-related disease
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2022/09/07
CRDT- 2022/09/26 17:46
PHST- 2022/03/31 00:00 [received]
PHST- 2022/08/12 00:00 [accepted]
PHST- 2022/09/26 17:46 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2022/09/07 00:00 [pmc-release]
AID - 10.3389/fmed.2022.909057 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Sep 7;9:909057. doi: 10.3389/fmed.2022.909057. 
      eCollection 2022.