PMID- 36160908
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 24
IP  - 4
DP  - 2022 Oct
TI  - TIPE2 protects cardiomyocytes from ischemia-reperfusion-induced apoptosis by 
      decreasing cell autophagy via the mTORC1 signaling pathway.
PG  - 613
LID - 10.3892/etm.2022.11550 [doi]
LID - 613
AB  - In cardiac ischemia-reperfusion (I/R), autophagy of hyperactivated cardiomyocytes 
      degrades normal proteins and organelles, destroys cells and causes irreversible 
      cell death. The present study aimed to determine the molecular mechanism through 
      which TNF-alpha-induced protein 8-like protein 2 (TIPE2) regulates cardiomyocyte 
      apoptosis via autophagy in I/R. The results revealed that the number of apoptotic 
      cells and the protein expression levels of TIPE2 in the heart tissue of I/R model 
      mice were significantly increased. In vitro, the overexpression of TIPE2 
      decreased oxygen glucose deprivation (OGD)-induced autophagy, apoptosis and 
      activation of the mTOR complex 1 (mTORC1) signaling pathway in H9c2 cells. 
      Treatment with the mTORC1 inhibitor not only inhibited the TIPE2-activated mTORC1 
      signaling pathway, but also increased OGD-induced autophagy and apoptosis of H9c2 
      cells. In conclusion, the results of the present study revealed that TIPE2 may 
      protect cardiomyocytes from I/R-induced apoptosis by decreasing cell autophagy 
      via the mTORC1 signaling pathway.
CI  - Copyright: (c) Cheng et al.
FAU - Cheng, Gong
AU  - Cheng G
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710068, P.R. China.
FAU - Huang, Xiaoyan
AU  - Huang X
AD  - Department of Central Laboratory, Shaanxi Provincial People's Hospital, Xi'an 
      Jiaotong University, Xi'an, Shaanxi 710068, P.R. China.
FAU - You, Penghua
AU  - You P
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710068, P.R. China.
FAU - Feng, Panpan
AU  - Feng P
AD  - Department of General Medicine, Shaanxi Provincial People's Hospital, Xi'an, 
      Shaanxi 710021, P.R. China.
FAU - Jia, Shuo
AU  - Jia S
AD  - Department of Emergency, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 
      710068, P.R. China.
FAU - Zhang, Ji
AU  - Zhang J
AD  - Department of Emergency, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 
      710068, P.R. China.
FAU - You, Hongjun
AU  - You H
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710068, P.R. China.
FAU - Chang, Fengjun
AU  - Chang F
AD  - Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong 
      University, Xi'an, Shaanxi 710068, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20220804
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC9490124
OTO - NOTNLM
OT  - TNF-alpha-induced protein 8-like protein 2
OT  - autophagy
OT  - mTOR complex 1
COIS- The authors declare that they have no competing interests.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2022/08/04
CRDT- 2022/09/26 17:57
PHST- 2019/09/19 00:00 [received]
PHST- 2019/12/20 00:00 [accepted]
PHST- 2022/09/26 17:57 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2022/08/04 00:00 [pmc-release]
AID - ETM-0-0-11550 [pii]
AID - 10.3892/etm.2022.11550 [doi]
PST - epublish
SO  - Exp Ther Med. 2022 Aug 4;24(4):613. doi: 10.3892/etm.2022.11550. eCollection 2022 
      Oct.