PMID- 36164388
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230917
IS  - 0976-5662 (Print)
IS  - 2213-3445 (Electronic)
IS  - 0976-5662 (Linking)
VI  - 34
DP  - 2022 Nov
TI  - Impact of age within younger populations on outcomes following cervical surgery 
      in the ambulatory setting.
PG  - 102016
LID - 10.1016/j.jcot.2022.102016 [doi]
LID - 102016
AB  - OBJECTIVE: To determine the effect of age within the younger population seen at 
      ambulatory surgical centers on patient-reported outcome measures (PROMs) after 
      cervical spine surgery. METHODS: Patients of age <65 years undergoing 
      single-level anterior cervical discectomy and fusion (ACDF) or cervical disc 
      replacement (CDR) were included. Patients were divided by mean age of initial 
      population (46 years). PROMs included Patient-reported Outcome Measurement 
      Information System Physical Function (PROMIS-PF), 12-Item Short-Form Physical 
      Component Survey (SF-12 PCS), Visual Analog Scale (VAS) neck, VAS arm, Neck 
      Disability Index (NDI) collected preoperatively and at postoperative time points 
      up to 2 years. RESULTS: 138 patients were included, with 66 patients <46 years. 
      Both cohorts demonstrated improvement from preoperative baseline with regard to 
      all studied PROMs at multiple time points postoperatively (p </= 0.042, all). 
      Between groups, the older cohort demonstrated greater mean PROMIS-PF scores 
      preoperatively and at 6 weeks (p </= 0.011, both), while VAS arm scores were lower 
      in the older group at 1 year (p = 0.002), and NDI scores were lower in the older 
      group at 6 weeks and 1 year (p < 0.027, both). Minimal Clinically Important 
      Difference (MCID) achievement rates were greater in the younger group in PROMIS 
      PF at 2 years (p = 0.002), and in the older group in VAS arm score at 1 year 
      (p = 0.007). CONCLUSION: Both cohorts showed significant improvement at multiple 
      postoperative time points for all PROMs. Between groups, the older group reported 
      more favorable physical function, VAS arm, and NDI scores at several time points. 
      However, MCID achievement rates only significantly differed in two PROMs at 
      singular time points. Difference in age in patients <65 years likely does not 
      significantly affect long-term outcomes after cervical spine surgery.
CI  - (c) 2022 Delhi Orthopedic Association. All rights reserved.
FAU - Hartman, Timothy J
AU  - Hartman TJ
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. 
      Harrison St. Suite #300, Chicago, IL, 60612, USA.
FAU - Nie, James W
AU  - Nie JW
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. 
      Harrison St. Suite #300, Chicago, IL, 60612, USA.
FAU - Pawlowski, Hanna
AU  - Pawlowski H
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. 
      Harrison St. Suite #300, Chicago, IL, 60612, USA.
FAU - Prabhu, Michael C
AU  - Prabhu MC
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. 
      Harrison St. Suite #300, Chicago, IL, 60612, USA.
FAU - Vanjani, Nisheka N
AU  - Vanjani NN
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. 
      Harrison St. Suite #300, Chicago, IL, 60612, USA.
FAU - Singh, Kern
AU  - Singh K
AD  - Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. 
      Harrison St. Suite #300, Chicago, IL, 60612, USA.
LA  - eng
PT  - Journal Article
DEP - 20220916
PL  - India
TA  - J Clin Orthop Trauma
JT  - Journal of clinical orthopaedics and trauma
JID - 101559469
PMC - PMC9508464
OTO - NOTNLM
OT  - ACDF
OT  - ACDF, anterior cervical discectomy and fusion
OT  - Age
OT  - CDR
OT  - CDR, cervical disc replacement
OT  - MCID
OT  - MCID, minimum clinically important difference
OT  - PROM
OT  - PROM, patient-reported outcome measure
COIS- The authors declare the following financial interests/personal relationships 
      which may be considered as potential competing interests: Kern Singh reports a 
      relationship with Zimmer Biomet that includes: consulting or advisory. Kern Singh 
      reports a relationship with Stryker that includes:. Kern Singh reports a 
      relationship with RTI Surgical that includes:. Kern Singh reports a relationship 
      with Lippincott Williams and Wilkins that includes:. Kern Singh reports a 
      relationship with Thieme that includes:. Kern Singh reports a relationship with 
      Jaycee Publishing that includes:. Kern Singh reports a relationship with Slack 
      Publishing that includes:. Kern Singh reports a relationship with Avaz Surgical 
      LLC that includes: equity or stocks. Kern Singh reports a relationship with Vital 
      5 LLC that includes: board membership and equity or stocks. Kern Singh reports a 
      relationship with K2M that includes: consulting or advisory. Kern Singh reports a 
      relationship with TDi LLC that includes: board membership. Kern Singh reports a 
      relationship with Minimally Invasive Spine Study Group that includes: board 
      membership. Kern Singh reports a relationship with Contemporary Spine Surgery 
      that includes: board membership. Kern Singh reports a relationship with 
      Orthopedics Today that includes: board membership. Kern Singh reports a 
      relationship with Vertebral Columns that includes: board membership. Kern Singh 
      reports a relationship with Cervical Spine Research Society that includes: board 
      membership. Kern Singh reports a relationship with International Society for the 
      Advancement of Spine Surgery that includes: board membership. Kern Singh reports 
      a relationship with American Academy of Orthopaedic Surgeons that includes: board 
      membership. Kern Singh reports a relationship with Cervical Spine Research 
      Society that includes: funding grants.
EDAT- 2022/09/28 06:00
MHDA- 2022/09/28 06:01
PMCR- 2023/09/16
CRDT- 2022/09/27 01:57
PHST- 2022/07/26 00:00 [received]
PHST- 2022/08/30 00:00 [revised]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/09/27 01:57 [entrez]
PHST- 2022/09/28 06:00 [pubmed]
PHST- 2022/09/28 06:01 [medline]
PHST- 2023/09/16 00:00 [pmc-release]
AID - S0976-5662(22)00252-1 [pii]
AID - 102016 [pii]
AID - 10.1016/j.jcot.2022.102016 [doi]
PST - epublish
SO  - J Clin Orthop Trauma. 2022 Sep 16;34:102016. doi: 10.1016/j.jcot.2022.102016. 
      eCollection 2022 Nov.