PMID- 36165005
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20230301
IS  - 1029-2292 (Electronic)
IS  - 0897-7194 (Linking)
VI  - 40
IP  - 5-6
DP  - 2022 Nov
TI  - High mobility group box 1 and Dickkopf-related protein 1 as biomarkers of glucose 
      toxicity, atherogenicity, and lower beta cell function in patients with type 2 
      diabetes mellitus.
PG  - 240-253
LID - 10.1080/08977194.2022.2126317 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with increased atherogenicity and 
      inflammatory responses, which may be related to high mobility group box 1 (HMGB1) 
      and Dickkopf-related protein 1 (DKK1). The role of HMGB1 and DKK1 in T2DM is 
      examined in association with lipid and insulin profiles. Serum HMGB1 and DKK1 
      were measured in T2DM with and without hypertension and compared with controls. 
      The results showed that HMGB1 and DKK1 are higher in T2DM irrespective of 
      hypertension. A large part of the variance in the beta-cell index and glucose 
      toxicity was explained by the combined effects of HMGB1 and DKK1. In conclusion, 
      both HMGB1 and DKK1 may contribute to increased atherogenicity in T2DM. Moreover, 
      both biomarkers may cause more deficits in beta-cell function and increase glucose 
      toxicity leading to the development of more inflammation and diabetic 
      complications. HMGB1 and the Wnt pathways are other drug targets in treating 
      T2DM.
FAU - Al-Hakeim, Hussein Kadhem
AU  - Al-Hakeim HK
AUID- ORCID: 0000-0001-6143-5196
AD  - Department of Chemistry, College of Science, University of Kufa, Kufa, Iraq.
FAU - Al-Kaabi, Qasim Jasim
AU  - Al-Kaabi QJ
AD  - Laboratories Division, Maysan Health Department, Misan Governorate, Misan, Iraq.
FAU - Maes, Michael
AU  - Maes M
AUID- ORCID: 0000-0002-2012-871X
AD  - Faculty of Medicine, Department of Psychiatry, Chulalongkorn University, Bangkok, 
      Thailand.
AD  - Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.
AD  - School of Medicine, IMPACT Strategic Research Centre, Deakin University, Geelong, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20220927
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (HMGB1 Protein)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/metabolism
MH  - *HMGB1 Protein
MH  - Glucose
MH  - Biomarkers
MH  - *Hypertension/complications
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - atherogenicity
OT  - biomarkers
OT  - inflammation
OT  - insulin resistance
EDAT- 2022/09/28 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/09/27 05:22
PHST- 2022/09/28 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/09/27 05:22 [entrez]
AID - 10.1080/08977194.2022.2126317 [doi]
PST - ppublish
SO  - Growth Factors. 2022 Nov;40(5-6):240-253. doi: 10.1080/08977194.2022.2126317. 
      Epub 2022 Sep 27.