PMID- 36165485
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20220928
IS  - 2282-4197 (Electronic)
IS  - 1124-3562 (Linking)
VI  - 94
IP  - 3
DP  - 2022 Sep 27
TI  - Systematic review of urinary biomarkers of female bladder outlet obstruction 
      (fBOO).
PG  - 355-359
LID - 10.4081/aiua.2022.3.355 [doi]
AB  - OBJECTIVE: Diagnosis of bladder outlet obstruction (BOO) in females is often 
      challenging, not only because of the overlap in storage and voiding symptoms in 
      women with various etiologies of lower urinary tract (LUT) dysfunction but also 
      due to the lack of standardized urodynamic criteria to define the condition. 
      There is an unmet need of biologic markers to evaluate BOO in females as an 
      adjunct to other clinical criteria. We sought to elucidate the role of urinary 
      biomarkers in female BOO. MATERIAL AND METHODS: We performed a systematic review 
      of studies involving urinary biomarkers in female BOO. The search was performed 
      in PubMed. A total of 58 papers were retrieved and 2 were included for final 
      analysis. RESULTS: Currently, there are no validated biologic markers for female 
      BOO available. Having a biomarker that can be obtained through a urine sample 
      will be an invaluable tool to evaluate and counsel patients with LUT symptoms and 
      possible BOO. The use of NGF as an indicator of BOO in female patients seems to 
      be promising: NGF levels are elevated in women with BOO when compared with normal 
      controls. CONCLUSIONS: We found that NGF levels may be applied as a useful 
      biomarker in the diagnosis and evaluation of female patients with BOO symptoms. 
      It will not completely replace other clinical diagnostic tools such as formal 
      urodynamic testing but play a role as a supplement to it. Nevertheless, further 
      studies should be conducted to establish NGF levels as a female BOO biomarker and 
      a routine testing modality.
FAU - Bile Silva, Andreia
AU  - Bile Silva A
AD  - Hospital de Egas Moniz, Lisboa. andreiabile@campus.ul.pt.
FAU - Dinis, Paulo Jorge
AU  - Dinis PJ
AD  - Hospital Cuf, Lisboa. pj.s.dinis@gmail.com.
FAU - Abranches Monteiro, Luis
AU  - Abranches Monteiro L
AD  - Hospital de Egas Moniz, Lisboa. abranchesmonteiro@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20220927
PL  - Italy
TA  - Arch Ital Urol Androl
JT  - Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa 
      italiana di ecografia urologica e nefrologica
JID - 9308247
RN  - 0 (Biomarkers)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Biomarkers/urine
MH  - Female
MH  - Humans
MH  - Nerve Growth Factor/urine
MH  - Urinary Bladder
MH  - *Urinary Bladder Neck Obstruction/diagnosis/etiology
MH  - Urodynamics
EDAT- 2022/09/28 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/09/27 08:00
PHST- 2022/05/12 00:00 [received]
PHST- 2022/06/05 00:00 [accepted]
PHST- 2022/09/27 08:00 [entrez]
PHST- 2022/09/28 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
AID - 10.4081/aiua.2022.3.355 [doi]
PST - epublish
SO  - Arch Ital Urol Androl. 2022 Sep 27;94(3):355-359. doi: 10.4081/aiua.2022.3.355.