PMID- 3616580
OWN - NLM
STAT- MEDLINE
DCOM- 19870918
LR  - 20131121
IS  - 0891-7035 (Print)
IS  - 0891-7035 (Linking)
VI  - 1
IP  - 2
DP  - 1987 Jun
TI  - Development of ocular inserts for cattle.
PG  - 863-9
AB  - Ring shaped ocular inserts have been developed to administer a therapeutic level 
      of tylosin tartrate throughout a five day period to treat pinkeye in cattle. The 
      inserts are based on polyvinyl chloride rings which are dip coated with a 
      copolymer containing the antibiotic (tylosin tartrate). Scanning electron 
      microscope (SEM) characterization of surfaces has been of value to evaluate the 
      presence and extent of surface flaws in the hydrogel coating, and to contribute 
      to improvement in fabrication of the rings to insure the establishment of 
      satisfactory seals at joints, uniformity of microporosity and cross sections, and 
      the absence of significant cracking or flaking. In vitro release rates were 
      determined using thin layer chromatography techniques, and rates were seen to be 
      above a few micrograms of antibiotic per hour for experiments as long as nine 
      days at simulated tear rates as high as 2 milliliters per hour.
FAU - Greer, R T
AU  - Greer RT
FAU - Ryoo, J P
AU  - Ryoo JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Scanning Microsc
JT  - Scanning microscopy
JID - 8704616
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Leucomycins)
RN  - 0 (Methacrylates)
RN  - 9002-86-2 (Polyvinyl Chloride)
RN  - YEF4JXN031 (Tylosin)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/*drug therapy
MH  - Conjunctivitis/drug therapy/*veterinary
MH  - Delayed-Action Preparations
MH  - Electron Probe Microanalysis
MH  - Leucomycins/*administration & dosage/therapeutic use
MH  - Methacrylates
MH  - Microscopy, Electron, Scanning
MH  - Polyvinyl Chloride
MH  - Tylosin
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
PST - ppublish
SO  - Scanning Microsc. 1987 Jun;1(2):863-9.