PMID- 36166847
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20230629
IS  - 2156-5376 (Electronic)
IS  - 2161-8313 (Print)
IS  - 2161-8313 (Linking)
VI  - 13
IP  - 6
DP  - 2022 Dec 22
TI  - Effects of Fish-Oil Consumption on Psychological Function Outcomes in Psychosis: 
      A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled 
      Trials.
PG  - 2149-2164
LID - 10.1093/advances/nmac083 [doi]
AB  - Research on the effects of fish oil on clinical symptoms and psychosocial 
      functioning in people with psychosis has been inconsistent. We conducted this 
      systematic review and meta-analysis to summarize the available data on the 
      effects of oral intake of fish oil on psychological functioning in patients with 
      psychosis. Three online databases including PubMed, Scopus, and Web of Science 
      were searched to identify relevant studies published by April 2021. The exposure 
      was oral fish-oil supplementation. The Positive and Negative Syndrome Scale 
      (PANSS), the Brief Psychiatric Rating Scale (BPRS), and the Global Assessment of 
      Functioning (GAF) were our outcome measures. Seventeen randomized clinical trials 
      involving 1390 patients were included. No change in PANSS was observed following 
      oral fish-oil intake [weighted mean difference (WMD): -0.87; 95% CI: -16.99, 
      15.26; P = 0.92]. In a nonlinear dose-response analysis, a significant inverse 
      association was observed between <10 wk of fish-oil supplementation and PANSS 
      (WMD: -10; P-nonlinearity = 0.02). Although analysis of 4 studies showed a 
      nonsignificant reduction in BPRS after fish-oil intake (WMD: -2.990; 95% CI: 
      -6.42, 0.44; P = 0.08), a nonlinear dose-response analysis revealed significant 
      inverse associations between dose (>2200 mg/d) and duration of fish-oil 
      supplementation (<15 wk) with BPRS score (WMD: -8; P-nonlinearity = 0.04). 
      Combined effect sizes from 6 randomized clinical trials showed significant 
      increases in GAF after oral administration of fish oil (WMD: 6.66; 95% CI: 3.39, 
      9.93; P < 0.001). In conclusion, we did not find any significant changes in PANSS 
      and BPRS scores following fish-oil supplementation. Nevertheless, oral fish-oil 
      intake significantly contributed to improvement in GAF scores. This is the first 
      meta-analysis to examine the effects of fish oil on the psychological functioning 
      scores of PANSS, BPRS, and GAF simultaneously.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Montazer, Mohsen
AU  - Montazer M
AUID- ORCID: 0000-0002-7472-0700
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Ebrahimpour-Koujan, Soraiya
AU  - Ebrahimpour-Koujan S
AUID- ORCID: 0000-0002-9613-3670
AD  - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
AD  - Autoimmune Bullous Disease Research Center, Razi Hospital, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Surkan, Pamela J
AU  - Surkan PJ
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA.
FAU - Azadbakht, Leila
AU  - Azadbakht L
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
AD  - Department of Community Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - United States
TA  - Adv Nutr
JT  - Advances in nutrition (Bethesda, Md.)
JID - 101540874
RN  - 0 (Fish Oils)
SB  - IM
MH  - Humans
MH  - *Fish Oils/pharmacology/therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - *Psychotic Disorders/drug therapy
MH  - Outcome Assessment, Health Care
MH  - Dietary Supplements
PMC - PMC9879727
OTO - NOTNLM
OT  - BPRS
OT  - GAF
OT  - PANSS
OT  - fish oil
OT  - psychosis
EDAT- 2022/09/28 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/09/27
CRDT- 2022/09/27 18:03
PHST- 2022/02/07 00:00 [received]
PHST- 2022/06/22 00:00 [revised]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/09/28 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/09/27 18:03 [entrez]
PHST- 2022/09/27 00:00 [pmc-release]
AID - S2161-8313(23)00069-8 [pii]
AID - nmac083 [pii]
AID - 10.1093/advances/nmac083 [doi]
PST - ppublish
SO  - Adv Nutr. 2022 Dec 22;13(6):2149-2164. doi: 10.1093/advances/nmac083.