PMID- 36167610
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230320
IS  - 1875-595X (Electronic)
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 73
IP  - 2
DP  - 2023 Apr
TI  - Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy.
PG  - 195-204
LID - S0020-6539(22)00200-3 [pii]
LID - 10.1016/j.identj.2022.08.006 [doi]
AB  - BACKGROUND: The aim of this work was to evaluate the efficacy of 
      proanthocyanidins (PACNs) as an adjunctive periodontal therapy in patients with 
      periodontitis. METHODS: Patients with periodontitis (stage III-IV) were included 
      in this randomised clinical study. Patients with periodontitis received 2 
      different treatment modalities: minimally invasive nonsurgical therapy only 
      (MINST group) or minimally invasive nonsurgical therapy and subgingival 
      application of collagen hydrogels with PACNs (MINST + PACNs group). Clinical 
      periodontal parameters, that is, pocket probing depth (PPD), clinical attachment 
      level (CAL), bleeding on probing (BOP), plaque index (PI), were evaluated before 
      treatment and after 8 weeks. Concentrations of immunologic markers, matrix 
      metalloproteinase-3 (MMP-3), and tissue inhibitor of matrix metalloproteinase-1 
      (TIMP-1) in saliva were assessed at baseline and at 8-week follow-up. RESULTS: 
      Forty-six patients diagnosed with periodontitis were randomised into 2 groups: 23 
      patients in the MINST group and 23 patients in the MINST + PACNs group received 
      the intended treatment. PACNs combined with MINST resulted in additional 
      statistically significant PPD reduction and CAL gain in moderate periodontal 
      pockets by 0.5 mm (P < .05) on average compared to MINST alone. Additional use of 
      PACNs did not result in additional statistically significant improvement of BOP 
      or PI values. Application of PACNs showed significant reduction of MMP-3 levels 
      in saliva after 8 weeks (P < .05). CONCLUSIONS: Adjunctive use of PACNs in MINST 
      resulted in better clinical outcomes for moderate pockets. Additional use of 
      PACNs improved MMP-3 concentration in saliva more than MINST alone. Biochemical 
      analysis revealed that MMP-3 concentration in saliva reflected the periodontal 
      health state.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Alkimaviciene, Evelina
AU  - Alkimaviciene E
AD  - Department of Dental and Oral Pathology, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania. Electronic address: evelina.alkimaviciene@lsmu.lt.
FAU - Pusinskaite, Rasa
AU  - Pusinskaite R
AD  - Department of Dental and Oral Pathology, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
FAU - Baseviciene, Nomeda
AU  - Baseviciene N
AD  - Department of Dental and Oral Pathology, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
FAU - Baniene, Rasa
AU  - Baniene R
AD  - Department of Biochemistry, Medical Academy, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
FAU - Savickiene, Nijole
AU  - Savickiene N
AD  - Department of Pharmacognosy, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Pacauskiene, Ingrida Marija
AU  - Pacauskiene IM
AD  - Department of Dental and Oral Pathology, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220924
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - 0 (Proanthocyanidins)
RN  - Primary angiitis of the central nervous system
SB  - IM
MH  - Humans
MH  - Matrix Metalloproteinase 3/therapeutic use
MH  - *Proanthocyanidins/therapeutic use
MH  - Dental Scaling/methods
MH  - *Periodontitis
MH  - *Chronic Periodontitis
PMC - PMC10023589
OTO - NOTNLM
OT  - Periodontal debridement
OT  - Periodontitis
OT  - Proanthocyanidins
OT  - Randomised controlled trial
COIS- Conflict of interest None disclosed.
EDAT- 2022/09/28 06:00
MHDA- 2023/03/15 06:00
PMCR- 2022/09/24
CRDT- 2022/09/27 23:39
PHST- 2022/04/15 00:00 [received]
PHST- 2022/06/25 00:00 [revised]
PHST- 2022/08/16 00:00 [accepted]
PHST- 2022/09/28 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2022/09/27 23:39 [entrez]
PHST- 2022/09/24 00:00 [pmc-release]
AID - S0020-6539(22)00200-3 [pii]
AID - 10.1016/j.identj.2022.08.006 [doi]
PST - ppublish
SO  - Int Dent J. 2023 Apr;73(2):195-204. doi: 10.1016/j.identj.2022.08.006. Epub 2022 
      Sep 24.