PMID- 36168688
OWN - NLM
STAT- MEDLINE
DCOM- 20220929
LR  - 20220929
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 122
IP  - 9
DP  - 2022
TI  - [Ampakines - a promising approach to neuroprotection].
PG  - 54-62
LID - 10.17116/jnevro202212209154 [doi]
AB  - Increased interest in glutamatergic neurotransmission emerged in the second half 
      of the twentieth century. Later, the role of glutamate neurotransmission in 
      learning and memory processes became clear. AMPA receptors (AMPR) and NMDA 
      receptors (NMDAR) turned out to be important links in the mechanism of long-term 
      potentiation (LTP) involved in memory processes, which was expressed in an 
      increase in the excitatory postsynaptic potential in response to repeated 
      stimuli. The data obtained in recent decades indicate that AMPR is the main 
      regulators of synaptic plasticity, learning and memory. In clinical terms, the 
      greatest interest is not the formation of memory traces in various parts of the 
      brain, but its restoration in various pathological processes, including 
      reactivation of connections between neurons activated by learning in various 
      areas of the brain. AMPAR synaptic plasticity disorder has been detected in 
      several neurodegenerative diseases accompanied by cognitive disorders. Ampakines, 
      a heterogeneous class of numerous small molecules that bind to the allosteric 
      site on the AMPAR receptor, which slows down the kinetics of AMPAR deactivation, 
      enhances excitatory synaptic current and enhances LTP, have become increasingly 
      attracting the attention of researchers.
FAU - Kiselev, A V
AU  - Kiselev AV
AUID- ORCID: 0000-0002-8807-405X
AD  - Semenov Federal Research Center for Chemical Physics, Moscow, Russia.
FAU - Kotov, A S
AU  - Kotov AS
AUID- ORCID: 0000-0003-2988-5706
AD  - Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russia.
FAU - Mikhaleva, M G
AU  - Mikhaleva MG
AUID- ORCID: 0000-0001-8192-6929
AD  - Semenov Federal Research Center for Chemical Physics, Moscow, Russia.
FAU - Stovbun, S V
AU  - Stovbun SV
AUID- ORCID: 0000-0001-8820-9615
AD  - Semenov Federal Research Center for Chemical Physics, Moscow, Russia.
FAU - Kotov, S V
AU  - Kotov SV
AUID- ORCID: 0000-0002-8706-7317
AD  - Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Ampakiny - novyi podkhod k neiroprotektsii.
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Glutamic Acid/metabolism
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Neuroprotection
MH  - *Receptors, AMPA/metabolism
MH  - *Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Synapses
MH  - Synaptic Transmission
OTO - NOTNLM
OT  - AMPAR
OT  - cognitive decline
OT  - glutamate transmission
OT  - poststroke rehabilitation
EDAT- 2022/09/29 06:00
MHDA- 2022/09/30 06:00
CRDT- 2022/09/28 02:28
PHST- 2022/09/28 02:28 [entrez]
PHST- 2022/09/29 06:00 [pubmed]
PHST- 2022/09/30 06:00 [medline]
AID - 10.17116/jnevro202212209154 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(9):54-62. doi: 
      10.17116/jnevro202212209154.