PMID- 36171838
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220930
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 8
DP  - 2022 Aug
TI  - Burkitt Lymphoma of the Appendix Presenting With Acute Appendicitis and Acute 
      Kidney Injury: A Case Report and Review of Literature.
PG  - e28392
LID - 10.7759/cureus.28392 [doi]
LID - e28392
AB  - The gastrointestinal tract is one of the most common sites for extranodal Burkitt 
      lymphomas (BLs), but an appendiceal BL is extremely rare. We describe a case of 
      appendiceal BL presenting with acute appendicitis and acute kidney injury. A 
      15-year-old obese male presented to the emergency department with fever and 
      right-sided abdominal pain. WBC count was slightly increased, and a CT scan of 
      the abdomen showed features of ruptured appendicitis and peritonitis. The patient 
      was placed on antibiotics, and an interval appendectomy was planned. The patient 
      developed a worsening acute kidney injury one day later, requiring a laparoscopic 
      appendectomy. Gross examination of the appendix revealed a dilated, firm, 
      sausage-like appendix with a hemorrhagic serosa and a firm mesoappendix. 
      Microscopic examination of the appendix showed a dense diffuse infiltration of 
      monomorphic medium-sized atypical lymphoid cells with round nuclei, dispersed 
      chromatin, and small nucleoli. Few scattered macrophages created a vague "starry 
      sky" appearance. Many mitotic figures were seen. The lesion also involved the 
      mesoappendix. Immunohistochemical analysis showed that the lymphoma expressed 
      CD10, CD20, and BCL6 but was negative for CD34, BCL2, and TdT. Later, the 
      fluorescence in situ hybridization (FISH) analysis detected an IGH-MYC (8;14) 
      fusion. A final diagnosis of appendicular Burkitt lymphoma was made. Two weeks 
      later, a bone marrow biopsy performed for staging showed involvement of bone 
      marrow by BL. The patient lost follow-up after that due to the transfer of care 
      to another hospital.
CI  - Copyright (c) 2022, Yahya et al.
FAU - Yahya, Hafiz A
AU  - Yahya HA
AD  - Pathology, University of Mississippi Medical Center, Jackson, USA.
FAU - Kumar, Vijay
AU  - Kumar V
AD  - Pathology, University of Mississippi Medical Center, Jackson, USA.
FAU - Lam, John T
AU  - Lam JT
AD  - Hematopathology, University of Mississippi Medical Center, Jackson, USA.
LA  - eng
PT  - Case Reports
DEP - 20220825
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9508895
OTO - NOTNLM
OT  - acute appendicitis
OT  - acute kidney injury
OT  - appendix
OT  - burkitt lymphoma
OT  - lymphoma
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/09/30 06:00
MHDA- 2022/09/30 06:01
PMCR- 2022/08/25
CRDT- 2022/09/29 02:05
PHST- 2022/08/25 00:00 [accepted]
PHST- 2022/09/29 02:05 [entrez]
PHST- 2022/09/30 06:00 [pubmed]
PHST- 2022/09/30 06:01 [medline]
PHST- 2022/08/25 00:00 [pmc-release]
AID - 10.7759/cureus.28392 [doi]
PST - epublish
SO  - Cureus. 2022 Aug 25;14(8):e28392. doi: 10.7759/cureus.28392. eCollection 2022 
      Aug.