PMID- 36171952
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220930
IS  - 0970-9185 (Print)
IS  - 2231-2730 (Electronic)
IS  - 0970-9185 (Linking)
VI  - 38
IP  - 2
DP  - 2022 Apr-Jun
TI  - The effect of type 2 diabetes mellitus on perioperative neurocognitive disorders 
      in patients undergoing elective noncardiac surgery under general anesthesia. A 
      prospective cohort study.
PG  - 252-262
LID - 10.4103/joacp.JOACP_292_20 [doi]
AB  - BACKGROUND AND AIMS: Preliminary evidence suggests a possible relationship 
      between type 2 diabetes mellitus (T2DM) and perioperative neurocognitive 
      disorders (NCD). We sought to investigate whether patients with T2DM, undergoing 
      elective noncardiac surgery under general anesthesia, are at increased risk of 
      perioperative NCD. MATERIAL AND METHODS: A prospective cohort study was designed. 
      One-hundred and forty-four patients with T2DM and 144 healthy controls were 
      recruited. Controls were matched for sex, age, type of operation, and educational 
      background. Postoperative delirium (POD), delayed neurocognitive recovery and 
      postoperative NCD were evaluated. RESULTS: Two hundred twenty-eight patients were 
      analyzed. Compared to controls, patients with T2DM were diagnosed with higher 
      rates of NCD preoperatively (n = 96 vs. n = 26, P < 0.05) and higher POD up to 4 
      days postoperatively (n = 204 vs. n = 68, P < 0.05). Increased rates of delayed 
      neurocognitive recovery and postoperative NCD were recorded in patients with T2DM 
      up to 9 months postoperatively (n = 473 vs. n = 192, P < 0.05). Insulin-dependent 
      patients had higher rates of POD on the second (n = 38 vs. n = 24, P < 0.05) and 
      third day (n = 27 vs. n = 16, P < 0.05) when compared to noninsulin-dependent 
      patients. Logistic multivariable analysis revealed that patients with T2DM are at 
      increased risk for postoperative cognitive disorders. CONCLUSION: Patients with 
      type 2 diabetes mellitus appear to be at a higher risk of perioperative NCDs up 
      to 9 months after elective noncardiac surgery under general anesthesia.
CI  - Copyright: (c) 2021 Journal of Anaesthesiology Clinical Pharmacology.
FAU - Ntalouka, Maria P
AU  - Ntalouka MP
AD  - Department of Anesthesiology and Postoperative Intensive Care, Faculty of 
      Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece; 
      Department of Anesthesiology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, Larissa, Greece.
FAU - Arnaoutoglou, Eleni
AU  - Arnaoutoglou E
AD  - Department of Anesthesiology, Faculty of Medicine, School of Health Sciences, 
      University of Thessaly, Larissa, Greece.
FAU - Vrakas, Spyridon
AU  - Vrakas S
AD  - Department of Gastroenterology, Tzaneio Hospital, Piraeus, Greece.
FAU - Staikou, Chryssoula
AU  - Staikou C
AD  - Department of Anaesthesiology, Aretaieio Hospital, National and Kapodistrian 
      University of Athens, Greece.
FAU - Angelis, Fragkiskos A
AU  - Angelis FA
AD  - Department of Orthopedics Surgery and Musculoskeletal Trauma, Medical School, 
      University of Thessaly, Larissa, Greece.
FAU - Papadopoulos, Georgios
AU  - Papadopoulos G
AD  - Department of Anesthesiology and Postoperative Intensive Care, Faculty of 
      Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
FAU - Tzimas, Petros
AU  - Tzimas P
AD  - Department of Anesthesiology and Postoperative Intensive Care, Faculty of 
      Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
LA  - eng
PT  - Journal Article
DEP - 20211215
PL  - India
TA  - J Anaesthesiol Clin Pharmacol
JT  - Journal of anaesthesiology, clinical pharmacology
JID - 9516972
PMC - PMC9511857
OTO - NOTNLM
OT  - Anesthesia
OT  - diabetes mellitus
OT  - elective surgical procedures
OT  - general
OT  - neurocognitive disorders
OT  - postoperative cognitive complications
OT  - type 2
COIS- There are no conflicts of interest.
EDAT- 2022/09/30 06:00
MHDA- 2022/09/30 06:01
PMCR- 2022/04/01
CRDT- 2022/09/29 02:07
PHST- 2021/02/22 00:00 [received]
PHST- 2021/04/13 00:00 [revised]
PHST- 2021/05/01 00:00 [accepted]
PHST- 2022/09/29 02:07 [entrez]
PHST- 2022/09/30 06:00 [pubmed]
PHST- 2022/09/30 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - JOACP-38-252 [pii]
AID - 10.4103/joacp.JOACP_292_20 [doi]
PST - ppublish
SO  - J Anaesthesiol Clin Pharmacol. 2022 Apr-Jun;38(2):252-262. doi: 
      10.4103/joacp.JOACP_292_20. Epub 2021 Dec 15.