PMID- 36172573
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220930
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Mechanism of tonifying-kidney Chinese herbal medicine in the treatment of chronic 
      heart failure.
PG  - 988360
LID - 10.3389/fcvm.2022.988360 [doi]
LID - 988360
AB  - According to traditional Chinese medicine (TCM), chronic heart failure has the 
      basic pathological characteristics of "heart-kidney yang deficiency." Chronic 
      heart failure with heart- and kidney-Yang deficiency has good overlap with New 
      York Heart Association (NYHA) classes III and IV. Traditional Chinese medicine 
      classical prescriptions for the treatment of chronic heart failure often take 
      "warming and tonifying kidney-Yang" as the core, supplemented by herbal 
      compositions with functions of "promoting blood circulation and dispersing blood 
      stasis." Nowadays, there are still many classical and folk prescriptions for 
      chronic heart failure treatment, such as Zhenwu decoction, Bushen Huoxue 
      decoction, Shenfu decoction, Sini decoction, as well as Qili Qiangxin capsule. 
      This review focuses on classical formulations and their active constituents that 
      play a key role in preventing chronic heart failure by suppressing inflammation 
      and modulating immune and neurohumoral factors. In addition, given that 
      mitochondrial metabolic reprogramming has intimate relation with inflammation, 
      cardiac hypertrophy, and fibrosis, the regulatory role of classical prescriptions 
      and their active components in metabolic reprogramming, including glycolysis and 
      lipid beta-oxidation, is also presented. Although the exact mechanism is unknown, 
      the classical TCM prescriptions still have good clinical effects in treating 
      chronic heart failure. This review will provide a modern pharmacological 
      explanation for its mechanism and offer evidence for clinical medication by 
      combining TCM syndrome differentiation with chronic heart failure clinical 
      stages.
CI  - Copyright (c) 2022 Chen, Yu, Ling and Xu.
FAU - Chen, Lizhen
AU  - Chen L
AD  - Institute of Interdisciplinary Medical Science, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Yu, Dayun
AU  - Yu D
AD  - Institute of Interdisciplinary Medical Science, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Ling, Shuang
AU  - Ling S
AD  - Institute of Interdisciplinary Medical Science, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Xu, Jin-Wen
AU  - Xu JW
AD  - Institute of Interdisciplinary Medical Science, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220912
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9510640
OTO - NOTNLM
OT  - chronic heart failure
OT  - classical prescription
OT  - energy metabolism
OT  - inflammation
OT  - neurohumoral factors
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/30 06:00
MHDA- 2022/09/30 06:01
PMCR- 2022/01/01
CRDT- 2022/09/29 02:22
PHST- 2022/07/07 00:00 [received]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/29 02:22 [entrez]
PHST- 2022/09/30 06:00 [pubmed]
PHST- 2022/09/30 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.988360 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Sep 12;9:988360. doi: 10.3389/fcvm.2022.988360. 
      eCollection 2022.