PMID- 36173045
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230610
IS  - 2212-3873 (Electronic)
IS  - 1871-5303 (Print)
IS  - 1871-5303 (Linking)
VI  - 23
IP  - 4
DP  - 2023
TI  - The Relationship between Serum Iron and Thyroid Function in the Patients with 
      Type 2 Diabetes.
PG  - 558-567
LID - 10.2174/1871530322666220928144548 [doi]
AB  - PURPOSE: Our primary objective in this study is to determine the relationship 
      between serum iron (Fe(3+)) and thyroid functions in type 2 diabetes mellitus 
      (T2DM) patients. MATERIALS AND METHODS: Glucose metabolic parameters, trace 
      elements, such as Fe(3+), and thyroid functions for 1657 type 2 diabetic patients 
      treated at the Shanghai Pudong Hospital's Department of Endocrinology from 2018 
      to 2021 were assessed. RESULTS: Variations in free thyroid hormones (FTH) and 
      total thyroid hormones (TTH) were insignificant; however, thyroid-stimulating 
      hormone (TSH) levels were markedly elevated in patients with positive thyroid 
      peroxidase antibody (TPOAb) and/or positive antithyroglobulin antibody (TgAb) 
      (p<0.05). Additionally, gender disparities affected FTH levels (p<0.05) but not 
      TTH and TSH levels. The female gender was significantly negatively correlated 
      with serum Fe levels (r=-0.381, p<0.05). Serum Fe(3+) deficiency also had an 
      effect on FT3 in both genders, FT4 and TT4 in males (p<0.05), but not TSH 
      (p>0.05). The multilinear regression model showed that TT3 (beta=0.702), eGFR 
      (beta=0.109), Fe(3+) (beta=0.003), female gender (beta=-0.061), and age (beta=-0.061) were 
      the major determinants for FT3 change. Moreover, renal function, which was 
      represented as the estimated glomerular filtration rate (eGFR), had no effects on 
      Fe(3+) and TSH levels but on the levels of FTH and TTH (p<0.05). FT3/FT4 
      exhibited correlations with Fe(3+) (r=0.252) and eGFR (r=0.285). Finally, changes 
      in Fe(3+) levels had no significant impact on fasting plasma glucose (FPG), 
      fasting C-peptide, HbA1c, and glycated albumin levels (p>0.05). CONCLUSION: In 
      addition to age, gender, and renal functions, serum Fe(3+) levels in T2DM 
      patients have a significant relationship with thyroid functions.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Wang, Congcong
AU  - Wang C
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
FAU - Wen, Song
AU  - Wen S
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
FAU - Yuan, Xinlu
AU  - Yuan X
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
FAU - Zhou, Mingyue
AU  - Zhou M
AD  - Clinical Research OB/GYN REI Division, University of California, San Francisco, 
      USA.
FAU - Li, Yanyan
AU  - Li Y
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
FAU - Gong, Min
AU  - Gong M
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
FAU - Jin, Jianlan
AU  - Jin J
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
FAU - Zhou, Ligang
AU  - Zhou L
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 
      201399, China.
AD  - Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai 
      Pudong Hospital, Shanghai, 201399, China.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Endocr Metab Immune Disord Drug Targets
JT  - Endocrine, metabolic & immune disorders drug targets
JID - 101269157
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - 0 (Thyroid Hormones)
RN  - E1UOL152H7 (Iron)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - *Thyroid Gland
MH  - Triiodothyronine
MH  - Thyroid Function Tests
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Thyrotropin
MH  - China/epidemiology
MH  - Thyroid Hormones
MH  - Iron
MH  - Thyroxine
PMC - PMC10249137
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - free thyroid hormones
OT  - serum iron
OT  - thyroid function
OT  - thyroid-stimulating hormone
OT  - total thyroid hormones
COIS- The authors declare no conflict of interest, financial or otherwise.
EDAT- 2022/09/30 06:00
MHDA- 2023/05/22 06:42
PMCR- 2023/06/08
CRDT- 2022/09/29 07:32
PHST- 2022/06/16 00:00 [received]
PHST- 2022/08/11 00:00 [revised]
PHST- 2022/08/30 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2022/09/30 06:00 [pubmed]
PHST- 2022/09/29 07:32 [entrez]
PHST- 2023/06/08 00:00 [pmc-release]
AID - EMIDDT-EPUB-126618 [pii]
AID - EMIDDT-23-558 [pii]
AID - 10.2174/1871530322666220928144548 [doi]
PST - ppublish
SO  - Endocr Metab Immune Disord Drug Targets. 2023;23(4):558-567. doi: 
      10.2174/1871530322666220928144548.