PMID- 36173507
OWN - NLM
STAT- MEDLINE
DCOM- 20230113
LR  - 20230202
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 38
IP  - 1
DP  - 2023 Jan
TI  - The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other 
      neurological disorders.
PG  - 1-16
LID - 10.1007/s11011-022-01091-5 [doi]
AB  - Glutamate is the major excitatory neurotransmitter in the central nervous system 
      (CNS). Excitatory amino acid transporters (EAATs) have important roles in the 
      uptake of glutamate and termination of glutamatergic transmission. Up to now, 
      five EAAT isoforms (EAAT1-5) have been identified in mammals. The main focus of 
      this review is EAAT2. This protein has an important role in the pathoetiology of 
      epilepsy. De novo dominant mutations, as well as inherited recessive mutation in 
      this gene, have been associated with epilepsy. Moreover, dysregulation of this 
      protein is implicated in a range of neurological diseases, namely amyotrophic 
      lateral sclerosis, alzheimer's disease, parkinson's disease, schizophrenia, 
      epilepsy, and autism. In this review, we summarize the role of EAAT2 in epilepsy 
      and other neurological disorders, then provide an overview of the therapeutic 
      modulation of this protein.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Alijanpour, Sahar
AU  - Alijanpour S
AUID- ORCID: 0000-0003-0734-6787
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Miryounesi, Mohammad
AU  - Miryounesi M
AUID- ORCID: 0000-0003-4705-3794
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Ghafouri-Fard, Soudeh
AU  - Ghafouri-Fard S
AUID- ORCID: 0000-0002-0223-499X
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220929
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Excitatory Amino Acid Transporter 2)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Excitatory Amino Acid Transporter 2/genetics/metabolism
MH  - *Epilepsy/genetics
MH  - *Schizophrenia/metabolism
MH  - Biological Transport
MH  - Glutamic Acid/metabolism
MH  - Mammals/metabolism
OTO - NOTNLM
OT  - Developmental and epileptic encephalopathy 41
OT  - EAAT2
OT  - Epilepsy
OT  - Genetic
OT  - Neurological disorders
OT  - SLC1A2
EDAT- 2022/09/30 06:00
MHDA- 2023/01/14 06:00
CRDT- 2022/09/29 11:17
PHST- 2022/07/14 00:00 [received]
PHST- 2022/09/15 00:00 [accepted]
PHST- 2022/09/30 06:00 [pubmed]
PHST- 2023/01/14 06:00 [medline]
PHST- 2022/09/29 11:17 [entrez]
AID - 10.1007/s11011-022-01091-5 [pii]
AID - 10.1007/s11011-022-01091-5 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2023 Jan;38(1):1-16. doi: 10.1007/s11011-022-01091-5. Epub 2022 
      Sep 29.