PMID- 36176950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221001
IS  - 2053-8855 (Print)
IS  - 2053-8855 (Electronic)
IS  - 2053-8855 (Linking)
VI  - 2022
IP  - 9
DP  - 2022 Sep
TI  - Multiple endocrine neoplasia type 1 with suspicion of Zollinger Ellison syndrome 
      in a family with history of renal stones and hypercalcemia in a limited resource 
      setting: a case report.
PG  - omac094
LID - 10.1093/omcr/omac094 [doi]
LID - omac094
AB  - Multiple endocrine neoplasia type 1 (MEN 1) syndrome is a rare autosomal dominant 
      endocrine tumour syndrome, which can be diagnosed clinically based on family 
      history and the existence of MEN 1-associated tumours or molecularly based on 
      genetic testing. We described the case of a Hispanic 55-year-old male presenting 
      with dysphagia, chest pain and diarrhoea for three months with a family history 
      of hypercalcaemia and nephrolithiasis in first-degree relatives. Primary 
      hyperparathyroidism was suggested by hypercalcaemia, elevated parathyroid hormone 
      level, hypercalciuria, nephrolithiasis on abdominal computed tomography scan and 
      enlarged parathyroid gland on computed tomography pulmonary angiogram. Also, 
      patient had hypergastrinemia and a hypodense lesion in the pancreas on computed 
      tomography scan of abdomen. These findings suggested MEN 1 syndrome with high 
      suspicion of associated Zollinger Ellison syndrome. Our case highlights the 
      importance of family history and high clinical suspicion in patients presenting 
      with primary hyperparathyroidism and hypergastrinemia.
CI  - (c) The Author(s) 2022. Published by Oxford University Press.
FAU - Hussain, Kamran
AU  - Hussain K
AUID- ORCID: 0000-0001-9771-0970
AD  - Department of Internal Medicine, Jamaica Hospital Medical Center, New York, USA.
FAU - Nahar, Jebun
AU  - Nahar J
AD  - Department of Internal Medicine, Jamaica Hospital Medical Center, New York, USA.
FAU - Abbas, Fakhar
AU  - Abbas F
AD  - Department of Internal Medicine, Jamaica Hospital Medical Center, New York, USA.
FAU - Nawar, Jasir
AU  - Nawar J
AD  - Bronx High School of Science, New York, USA.
FAU - Anand, Ayush
AU  - Anand A
AUID- ORCID: 0000-0003-0279-4636
AD  - B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
LA  - eng
PT  - Case Reports
DEP - 20220926
PL  - England
TA  - Oxf Med Case Reports
JT  - Oxford medical case reports
JID - 101642070
PMC - PMC9514100
EDAT- 2022/10/01 06:00
MHDA- 2022/10/01 06:01
PMCR- 2022/09/26
CRDT- 2022/09/30 02:38
PHST- 2022/05/16 00:00 [received]
PHST- 2022/07/04 00:00 [revised]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/09/30 02:38 [entrez]
PHST- 2022/10/01 06:00 [pubmed]
PHST- 2022/10/01 06:01 [medline]
PHST- 2022/09/26 00:00 [pmc-release]
AID - omac094 [pii]
AID - 10.1093/omcr/omac094 [doi]
PST - epublish
SO  - Oxf Med Case Reports. 2022 Sep 26;2022(9):omac094. doi: 10.1093/omcr/omac094. 
      eCollection 2022 Sep.