PMID- 36177478
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - Iron deposition heterogeneity in extrapyramidal system assessed by quantitative 
      susceptibility mapping in Parkinson's disease patients with type 2 diabetes 
      mellitus.
PG  - 975390
LID - 10.3389/fnagi.2022.975390 [doi]
LID - 975390
AB  - PURPOSE: Excessive brain iron depositions were found in both patients with 
      Parkinson's disease (PD) and those with type 2 diabetes mellitus (T2DM). The 
      present study aimed to explore iron deposition and heterogeneity in the 
      extrapyramidal system in PD patients with T2DM using quantitative susceptibility 
      mapping (QSM) and further to reveal the effect of T2DM on the changes in brain 
      iron in patients with PD. MATERIALS AND METHODS: A total of 38 PD patients with 
      T2DM (PDDM), 30 PD patients without T2DM (PDND), and 20 asymptomatic control 
      subjects (CSs) were recruited for this study. All subjects underwent multiple MRI 
      sequences involving enhanced gradient echo T2 star weighted angiography (ESWAN). 
      The magnetic sensitivity values (MSV) and volume of the whole nuclei (MSV(W), 
      V(W)) and high iron region (MSV(RII), V(RII)) were measured on the bilateral 
      caudate nucleus (CN), the putamen (PUT), the globus pallidus (GP), the substantia 
      nigra (SN), the red nucleus (RN) and the dentate nucleus (DN). Clinical and 
      laboratory data were recorded, especially for the Hoehn and Yahr (H-Y) stage, the 
      Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), 
      the Hamilton Depression Rating Scale (HAMD), and the Hamilton Anxiety Rating 
      Scale (HAMA). All QSM data were compared between PDDM and PDND groups and 
      correlated with clinical and laboratory data. RESULTS: Compared to the PDND 
      group, the V(RII/)V(W) of the left CN was significantly increased in the PDDM 
      group. Significantly higher MSV(W) and MSV(RII) were also found in the PDDM 
      group, including bilateral SN of MSV(W), right PUT, and bilateral CN, GP, and SN 
      of MSV(RII). The H-Y stage of the PDDM group was significantly higher than that 
      of the PDND group. The MSV(RII) of bilateral RN of the PDDM group was positively 
      correlated with the HAMA scores. HDL, DBP, and SBP levels were associated with 
      MSV(RII) of right CN in the PDDM group. CONCLUSION: T2DM could aggravate the 
      disease severity and anxiety in patients with PD. The iron distribution of deep 
      gray matter nuclei in PD patients with T2DM was significantly heterogeneous, 
      which was related to blood pressure and blood lipids.
CI  - Copyright (c) 2022 Li, Gao, Du, Jiang, Yang, Hu, Liu, Liu, Zhang, Song and Miao.
FAU - Li, Wanyao
AU  - Li W
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Gao, Bingbing
AU  - Gao B
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Du, Wei
AU  - Du W
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Jiang, Yuhan
AU  - Jiang Y
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Hu, Rui
AU  - Hu R
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Liu, Yangyingqiu
AU  - Liu Y
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Liu, Na
AU  - Liu N
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Zhang, Yukun
AU  - Zhang Y
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Song, Qingwei
AU  - Song Q
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Miao, Yanwei
AU  - Miao Y
AD  - Department of Radiology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
LA  - eng
PT  - Journal Article
DEP - 20220913
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9513156
OTO - NOTNLM
OT  - Parkinson's disease
OT  - heterogeneity
OT  - iron
OT  - magnetic sensitivity value
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/01 06:00
MHDA- 2022/10/01 06:01
PMCR- 2022/01/01
CRDT- 2022/09/30 02:49
PHST- 2022/06/22 00:00 [received]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/09/30 02:49 [entrez]
PHST- 2022/10/01 06:00 [pubmed]
PHST- 2022/10/01 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.975390 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Sep 13;14:975390. doi: 10.3389/fnagi.2022.975390. 
      eCollection 2022.