PMID- 36177734
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221018
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 13
IP  - 20
DP  - 2022 Oct 17
TI  - Maternal propionate supplementation ameliorates glucose and lipid metabolic 
      disturbance in hypoxia-induced fetal growth restriction.
PG  - 10724-10736
LID - 10.1039/d2fo01481e [doi]
AB  - Intrauterine growth restriction (IUGR), one of the major complications of 
      pregnancy, is characterized by low birth weight and results in higher risks for 
      long-term problems including developing metabolic and cardiovascular diseases. 
      Short-chain fatty acids (SCFAs), especially propionate, have been reported to 
      correct glucose and lipid disorders in metabolic diseases. We hypothesized that 
      maternal propionate supplementation could prevent glucose and lipid metabolic 
      disturbance in hypoxia-induced IUGR. Here, in our study, maternal hypoxia was 
      induced from gestational day (GD) 11 to GD 17.5 to establish an IUGR mouse model. 
      Maternal propionate treatment reversed reduced birth weight in male IUGR 
      offspring. Hepatic transcriptomics demonstrated that SP treatment significantly 
      lowered glucose and lipid metabolism-related genes (Scd1, G6pc, Pck1 and Fasl) in 
      IUGR offspring. KOG enrichment analysis showed that propionate-induced 
      down-regulated differential expressed genes (DEGs) mainly belonged to lipid 
      transport and metabolism. KEGG enrichment results showed that the down-regulated 
      DEGs were mostly enriched in PPAR and FoxO signaling pathways. We also found that 
      maternal oral administration of SP decreased serum lipid content, attenuated 
      hepatic insulin resistance and liver lipid accumulation, reduced hepatic key gene 
      expressions of gluconeogenesis and lipogenesis, increased energy expenditure and 
      improved liver function in 11-week-old male IUGR offspring. These results 
      indicate that maternal propionate supplementation increases birth weight and 
      corrects hepatic glucose and lipid metabolic disturbance and energy expenditure 
      in male mice born with IUGR, which may provide a basis for using propionate to 
      treat IUGR disease.
FAU - Chen, Dan
AU  - Chen D
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Wang, Ying-Ying
AU  - Wang YY
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Li, Sheng-Peng
AU  - Li SP
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Zhao, Hui-Min
AU  - Zhao HM
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Jiang, Feng-Juan
AU  - Jiang FJ
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Wu, Ya-Xian
AU  - Wu YX
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Tong, Ying
AU  - Tong Y
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
FAU - Pang, Qing-Feng
AU  - Pang QF
AUID- ORCID: 0000-0003-0679-4780
AD  - Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, 1800 
      Lihu Avenue, Binhu District, Wuxi 214122, Jiangsu Province, China. 
      qfpang@jiangnan.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221017
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - 0 (Propionates)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Dietary Supplements
MH  - Female
MH  - *Fetal Growth Retardation/drug therapy/metabolism
MH  - *Glucose/metabolism
MH  - Humans
MH  - Hypoxia/drug therapy
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Peroxisome Proliferator-Activated Receptors/metabolism
MH  - Pregnancy
MH  - Propionates/metabolism
EDAT- 2022/10/01 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/09/30 04:02
PHST- 2022/10/01 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/09/30 04:02 [entrez]
AID - 10.1039/d2fo01481e [doi]
PST - epublish
SO  - Food Funct. 2022 Oct 17;13(20):10724-10736. doi: 10.1039/d2fo01481e.