PMID- 36178014
OWN - NLM
STAT- MEDLINE
DCOM- 20221109
LR  - 20221109
IS  - 2047-4849 (Electronic)
IS  - 2047-4830 (Linking)
VI  - 10
IP  - 22
DP  - 2022 Nov 8
TI  - Preparation and characterization of flexible furosemide-loaded biodegradable 
      microneedles for intradermal drug delivery.
PG  - 6486-6499
LID - 10.1039/d2bm01143c [doi]
AB  - Transdermal drug delivery systems are a useful and minimally invasive alternative 
      to other drug administration routes. Biodegradable polymeric microneedles (MNs) 
      are widely used in controlled-release drug delivery due to their tunable 
      properties and ease of patient self-administration. Polylactic-co-glycolic acid 
      (PLGA) is often used for sustained drug release owing to special intrinsic 
      properties including biocompatibility and biodegradability, which offer excellent 
      applicability in preparing MNs. Congestive heart failure (CHF) is characterized 
      by fluid overload during acute exacerbation, necessitating frequent patient 
      hospitalization for continuous intravenous (i.v.) diuretic therapy. In the 
      present study, we incorporated furosemide (FUR) as a model drug into flexible 
      PLGA MN skin patches for potential intradermal delivery to overcome the 
      limitations associated with i.v. diuresis. The MNs were fabricated by a 
      casting-mold technique and consisted of two main parts, PLGA needle tips loaded 
      with varying concentrations of FUR and a flexible backing layer comprising sodium 
      alginate and glycerol. MN formulations were characterized by SEM and exhibited a 
      uniform pyramidal shape. The measured surface pH of all samples suggested that no 
      skin irritation is expected upon application. High encapsulation efficiency was 
      obtained for FUR-MN formulations in which a decrease was noted as the FUR/PLGA 
      ratio decreased. Drug loading content ranged from 19.1 +/- 1% to 28.9 +/- 1.4%. 
      Successful insertion of MNs into a Parafilm(R) skin simulant model suggested that 
      MNs will easily penetrate the skin's outermost layer, the stratum corneum, and 
      will permit intradermal delivery of FUR. The MNs were further characterized by 
      analytical methods. Finally, the MNs exhibited an initial burst release followed 
      by a sustained release of FUR. Self-administered FUR-MNs can open new avenues to 
      overcome i.v. drip limitations and increase patient compliance.
FAU - Abu-Much, Arsalan
AU  - Abu-Much A
AUID- ORCID: 0000-0002-0626-6649
AD  - Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
AD  - Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
FAU - Darawshi, Raya
AU  - Darawshi R
AD  - Department of Pharmaceutical Engineering, Azrieli College of Engineering 
      Jerusalem, 26 Yaakov Shreibom Street, Ramat Beit Hakerem, Jerusalem 9103501, 
      Israel. aimanab@jce.ac.il.
FAU - Dawud, Hala
AU  - Dawud H
AD  - Department of Pharmaceutical Engineering, Azrieli College of Engineering 
      Jerusalem, 26 Yaakov Shreibom Street, Ramat Beit Hakerem, Jerusalem 9103501, 
      Israel. aimanab@jce.ac.il.
FAU - Kasem, Haytam
AU  - Kasem H
AD  - Department of Mechanical Engineering, Azrieli College of Engineering Jerusalem, 
      Jerusalem, Israel.
FAU - Abu Ammar, Aiman
AU  - Abu Ammar A
AUID- ORCID: 0000-0002-2556-3120
AD  - Department of Pharmaceutical Engineering, Azrieli College of Engineering 
      Jerusalem, 26 Yaakov Shreibom Street, Ramat Beit Hakerem, Jerusalem 9103501, 
      Israel. aimanab@jce.ac.il.
LA  - eng
PT  - Journal Article
DEP - 20221108
PL  - England
TA  - Biomater Sci
JT  - Biomaterials science
JID - 101593571
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - Humans
MH  - *Furosemide
MH  - *Drug Delivery Systems/methods
MH  - Administration, Cutaneous
MH  - Needles
MH  - Drug Liberation
EDAT- 2022/10/01 06:00
MHDA- 2022/11/10 06:00
CRDT- 2022/09/30 06:13
PHST- 2022/10/01 06:00 [pubmed]
PHST- 2022/11/10 06:00 [medline]
PHST- 2022/09/30 06:13 [entrez]
AID - 10.1039/d2bm01143c [doi]
PST - epublish
SO  - Biomater Sci. 2022 Nov 8;10(22):6486-6499. doi: 10.1039/d2bm01143c.