PMID- 36179844
OWN - NLM
STAT- MEDLINE
DCOM- 20221123
LR  - 20221123
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 856
IP  - Pt 1
DP  - 2023 Jan 15
TI  - West African e-waste-soil assessed with a battery of cell-based bioassays.
PG  - 159068
LID - S0048-9697(22)06167-8 [pii]
LID - 10.1016/j.scitotenv.2022.159068 [doi]
AB  - Soil samples randomly taken from major e-waste sites in West Africa (Nigeria, 
      Benin and Ghana) were examined for an extensive range of organic contaminants. 
      Cytotoxicity measurements and assessment of activation of xeno-sensing receptors 
      from fish (Atlantic cod) were employed as a battery of in vitro biological assays 
      to explore the quality and toxicity profile of West African e-waste soil. The 
      concentrations of the measured contaminants of emerging concerns (CECs) and 
      persistent organic pollutants (POPs) in the e-waste soil differs significantly 
      from the reference soil with chemical profiles typically dominated by legacy 
      polybrominated diphenyl ethers (PBDEs) (405.8 mugkg(-1)) and emerging 
      organophosphate ester flame retardant tris (1-chloro-2-propyl) phosphate (TCPP) 
      (404 mugkg(-1)), in addition to the short chain perfluorobutane sulfonate (PFBS) 
      (275.3 mugkg(-1)) and perfluorobutanoate (PFBA) (16 mugkg(-1)). The study revealed 
      that perfluorooctanoic acid (PFOA) occurred only in e-waste soil from Ghana and 
      ranged from 2.6 to 5.0 mugkg(-1). Overall, non-polar e-waste soil-derived extracts 
      had a stronger effect on COS-7 cell viability than the polar extracts and 
      elutriates. The highest receptor activation was observed with single polar and 
      non-polar extracts from the Nigeria and Benin sites, indicating hotspots with 
      Er-, PPARa- and Ahr-agonist activities. Thus, the results obtained with our 
      battery of in vitro biological assays underscored these e-waste sites as 
      remarkably polluted spots with complex toxicity profiles of great concern for 
      human and environmental health.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Eze, Chukwuebuka ThankGod
AU  - Eze CT
AD  - Department of Biochemistry, Federal University Oye-Ekiti, Ekiti State, Nigeria; 
      Department of Zoology, University of Lagos, Akoka-Yaba, Lagos State, Nigeria; 
      Department of Biological Sciences, University of Bergen, Bergen, Norway. 
      Electronic address: thankgod.eze@fuoye.edu.ng.
FAU - Otitoloju, Adebayo Akeem
AU  - Otitoloju AA
AD  - Department of Zoology, University of Lagos, Akoka-Yaba, Lagos State, Nigeria.
FAU - Eze, Obianuju Oluchukwu
AU  - Eze OO
AD  - Department of Biochemistry, University of Nigeria Nsukka, Enugu State, Nigeria.
FAU - Ugochukwu, Tochukwu Ernest
AU  - Ugochukwu TE
AD  - Department of Civil Engineering, Federal University Oye-Ekiti, Ekiti State, 
      Nigeria.
FAU - Onodugo, Chinemelum
AU  - Onodugo C
AD  - Department of Biochemistry, Federal University Oye-Ekiti, Ekiti State, Nigeria.
FAU - Ali, Aasim Musa
AU  - Ali AM
AD  - Section of Contaminants and Biohazards, Institute of Marine Research (IMR), P.O 
      1870 Nordnes, NO-5817 Bergen, Norway.
FAU - Lyche, Jan Ludvig
AU  - Lyche JL
AD  - Department of Food Safety and Infection Biology, Norwegian University of Life 
      Sciences, Oslo, Norway.
FAU - Karlsen, Odd Andre
AU  - Karlsen OA
AD  - Department of Biological Sciences, University of Bergen, Bergen, Norway.
FAU - Goksoyr, Anders
AU  - Goksoyr A
AD  - Department of Biological Sciences, University of Bergen, Bergen, Norway.
LA  - eng
PT  - Journal Article
DEP - 20220927
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Soil)
RN  - 0 (Soil Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Soil
MH  - *Electronic Waste/analysis
MH  - *Soil Pollutants/toxicity/analysis
MH  - Environmental Monitoring/methods
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Biological Assay
MH  - Ghana
OTO - NOTNLM
OT  - Atlantic cod
OT  - Cytotoxicity
OT  - E-waste soil
OT  - Luciferase assay
OT  - Organic pollutants
OT  - Stress-activated receptors
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/10/01 06:00
MHDA- 2022/11/24 06:00
CRDT- 2022/09/30 19:32
PHST- 2022/04/06 00:00 [received]
PHST- 2022/09/17 00:00 [revised]
PHST- 2022/09/23 00:00 [accepted]
PHST- 2022/10/01 06:00 [pubmed]
PHST- 2022/11/24 06:00 [medline]
PHST- 2022/09/30 19:32 [entrez]
AID - S0048-9697(22)06167-8 [pii]
AID - 10.1016/j.scitotenv.2022.159068 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Jan 15;856(Pt 1):159068. doi: 
      10.1016/j.scitotenv.2022.159068. Epub 2022 Sep 27.