PMID- 36180298
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221202
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 32
IP  - 12
DP  - 2022 Dec
TI  - Relation of genetic polymorphisms in microRNAs with diastolic and systolic 
      function in type 2 diabetes mellitus.
PG  - 2877-2882
LID - S0939-4753(22)00371-4 [pii]
LID - 10.1016/j.numecd.2022.09.002 [doi]
AB  - BACKGROUND AND AIMS: Type 2 diabetes mellitus (T2DM) has high risk of developing 
      cardiac dysfunction, increasing of either cardiovascular death or hospitalization 
      for heart failure. MicroRNAs (miRNA) affect cardiac function of T2DM. The aim of 
      this study was to investigate the relationships between five miRNA single 
      nucleotide polymorphisms (SNP) and diastolic and systolic function of T2DM. 
      METHODS AND RESULTS: Three hundred untreated T2DM subjects were included. Each 
      subject underwent SNP genotyping, conventional echocardiography, tissue doppler 
      imaging, and speckle tracking imaging. The effects of miRNA SNPs on diastolic and 
      systolic function were evaluated. The diastolic function of T2DM subjects with 
      miR-133a-1-rs8089787 wild genotype or let-7f-rs10877887 variant genotype was 
      lower than those with miR-133a-1-rs8089787 variant genotype or let-7f-rs10877887 
      wild genotype, manifesting as higher left atrial volume index, lower mean E', and 
      higher E/E' (P < 0.05). There were no significant effects of 
      miR-133a-2-rs13040413, let-7a-1-rs13293512 and miR-27a-rs895819 on the diastolic 
      function of T2DM subjects (P > 0.05). These five miRNA SNPs had no effect on the 
      systolic function of T2DM subjects (P > 0.05). CONCLUSIONS: 
      MiRNA-133a-1-rs8089787 and let-7f-rs10877887 were associated with impaired 
      cardiac diastolic function in T2DM. The findings may be a promising therapeutic 
      targets for preventing diastolic dysfunction in T2DM.
CI  - Copyright (c) 2022 The Italian Diabetes Society, the Italian Society for the Study 
      of Atherosclerosis, the Italian Society of Human Nutrition and the Department of 
      Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 
      All rights reserved.
FAU - Sun, Dandan
AU  - Sun D
AD  - Department of Cardiac Function, The People's Hospital of China Medical University 
      and the People's Hospital of Liaoning Province, Shenyang 110016, China; 
      Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China 
      Medical University, Shenyang 110001, China.
FAU - Zhu, Zaihan
AU  - Zhu Z
AD  - Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China 
      Medical University, Shenyang 110001, China.
FAU - Zhang, Yanfen
AU  - Zhang Y
AD  - Department of Ultrasonography, The People's Hospital of Zhengzhou University, 
      Zhengzhou 450003, China.
FAU - Bai, Ruocen
AU  - Bai R
AD  - Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China 
      Medical University, Shenyang 110001, China.
FAU - Zhu, Fang
AU  - Zhu F
AD  - Department of Cardiac Function, The People's Hospital of China Medical University 
      and the People's Hospital of Liaoning Province, Shenyang 110016, China.
FAU - Shan, Zhongyan
AU  - Shan Z
AD  - Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning 
      Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of 
      China Medical University, Shenyang 110001, China.
FAU - Ma, Chunyan
AU  - Ma C
AD  - Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China 
      Medical University, Shenyang 110001, China. Electronic address: 
      cmu1h_mcy@126.com.
FAU - Yang, Jun
AU  - Yang J
AD  - Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China 
      Medical University, Shenyang 110001, China. Electronic address: 
      junyang63@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220913
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/diagnosis/genetics/complications
MH  - *MicroRNAs/genetics
MH  - Diastole
MH  - Polymorphism, Single Nucleotide
MH  - Systole
MH  - *Ventricular Dysfunction, Left/diagnostic imaging/genetics
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Diastolic function
OT  - MicroRNA
OT  - Polymorphism
OT  - Systolic function
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declares that they have no 
      competing interests.
EDAT- 2022/10/01 06:00
MHDA- 2022/11/23 06:00
CRDT- 2022/09/30 22:04
PHST- 2021/11/29 00:00 [received]
PHST- 2022/08/31 00:00 [revised]
PHST- 2022/09/02 00:00 [accepted]
PHST- 2022/10/01 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/09/30 22:04 [entrez]
AID - S0939-4753(22)00371-4 [pii]
AID - 10.1016/j.numecd.2022.09.002 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2022 Dec;32(12):2877-2882. doi: 
      10.1016/j.numecd.2022.09.002. Epub 2022 Sep 13.