PMID- 36181062
OWN - NLM
STAT- MEDLINE
DCOM- 20221004
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 39
DP  - 2022 Sep 30
TI  - Clinical evidence of Xinbao Pills efficacy on chronic heart failure patients: A 
      protocol for systematic review and meta-analysis.
PG  - e30764
LID - 10.1097/MD.0000000000030764 [doi]
LID - e30764
AB  - BACKGROUND: Chronic heart failure (CHF) is a common cardiovascular disease and 
      results in high rate of morbidity, mortality, hospitalizations, and disability, 
      causing medical concern around the world. Xinbao Pill (XBP) has been widely 
      applied to clinical practice for patients with CHF but lacks studies to verify 
      its efficacy. This study provides a protocol of systematic review, with which we 
      will verify the adjunctive efficacy and safety of XBP on CHF with evidence-based 
      studies. METHODS: Included studies will be retrieved according to inclusion and 
      exclusion criteria from five English databases (the MEDLINE via PubMed, the 
      Cochrane Library, EMBASE, the Web of Science and Ovid database), and four Chinese 
      databases (China Science and Technology Journal Database [VIP], Chinese 
      Biomedical Literature Database [CBM], Wan-fang Database, China National Knowledge 
      Infrastructure [CNKI]) from October 1990 to October 2018. The New York Heart 
      Association (NYHA), heart rate and mortality will be marked as major outcomes. We 
      will use RevMan V.5.3 software to calculate the data synthesis and will conduct 
      meta-analysis based on the collected data. RESULTS: Mortality, NYHA function 
      classification, heart rate, the left ventricular ejection fractions (LVEF), 
      6-minute walk test (6MWT), hospitalization or rehospitalization, NT-proBNP, and 
      adverse effects will be measured and comprehensively assessed to evaluate the 
      adjunctive effect of XBP on CHF from this systematic review and meta-analysis 
      with current clinical evidence. CONCLUSION: The systematic review and 
      meta-analysis will assess the adjunctive effect of XBP in the treatment of CHF 
      with up-to-date clinical evidence.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Huang, Manhua
AU  - Huang M
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
FAU - Li, Zunjaing
AU  - Li Z
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
FAU - Fan, Ye
AU  - Fan Y
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
FAU - Li, Dongli
AU  - Li D
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
FAU - Liu, Quanle
AU  - Liu Q
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
FAU - Chen, Baijian
AU  - Chen B
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
FAU - Peng, Zhe
AU  - Peng Z
AD  - The Second Clinical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong, China.
FAU - Ding, Banghan
AU  - Ding B
AUID- ORCID: 0000-0002-1555-5055
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Chronic Disease
MH  - *Heart Failure/drug therapy
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Research Design
MH  - Stroke Volume
MH  - Systematic Reviews as Topic
MH  - Ventricular Function, Left
PMC - PMC9524988
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2022/10/02 06:00
MHDA- 2022/10/05 06:00
PMCR- 2022/09/30
CRDT- 2022/10/01 01:02
PHST- 2022/10/01 01:02 [entrez]
PHST- 2022/10/02 06:00 [pubmed]
PHST- 2022/10/05 06:00 [medline]
PHST- 2022/09/30 00:00 [pmc-release]
AID - 00005792-202209300-00060 [pii]
AID - 10.1097/MD.0000000000030764 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2022 Sep 30;101(39):e30764. doi: 
      10.1097/MD.0000000000030764.