PMID- 36181618
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20230228
IS  - 2212-1358 (Electronic)
IS  - 2212-134X (Linking)
VI  - 11
IP  - 1
DP  - 2023 Jan
TI  - Impact of surgical treatment on parent-reported health related quality of life 
      measures in early-onset scoliosis: stable but no improvement at 2 years.
PG  - 213-223
LID - 10.1007/s43390-022-00572-y [doi]
AB  - PURPOSE: The etiology of early-onset scoliosis (EOS) has been shown to 
      significantly influence baseline parent-reported health-related quality of life 
      (HRQoL) measures as assessed by the Early Onset Scoliosis Questionnaire (EOSQ). 
      We sought to assess the influence of distraction-based surgery and scoliosis 
      etiology on EOSQ 2 years following surgical intervention remains unclear. 
      METHODS: A retrospective review of a multi-center prospective EOS database was 
      performed. Children untreated with distraction-based, growth friendly 
      instrumentation for EOS with completed baseline and 2-year post-surgical EOSQ 
      were included. Children were subdivided by curve etiology individually and in 
      combined cohorts (congenital/idiopathic [C/I], neuromuscular/syndromic [NMS]). 
      EOSQ domains and compositive HRQoL score at presentation and 2-year follow-up 
      were compared across C-EOS etiologies. Minimal clinically important difference 
      (MCID) was defined as >/= 20% change in domain score and compared across 
      etiologies. RESULTS: 150 children with EOS met inclusion criteria (mean 
      7.09 +/- 2.6 years, 58.9% female). There were no differences in EOSQ domains 
      between Congenital vs. Idiopathic nor NM vs. Syndromic etiologies at any 
      timepoint. Combined C/I children demonstrated significantly higher EOSQ scores 
      than combined NMS at initial and 2-years post-treatment. Etiology remained the 
      only independent predictor of 2-year EOSQ composite HRQoL score. Overall, the 
      vast majority of children demonstrated stable HRQoL composite scores, with a 
      trend toward more positive MCID in NMS etiologies. CONCLUSION: EOS etiology 
      remains the most significant influence on EOSQ scores 2 years following surgical 
      intervention. However, the majority of patients, regardless of etiology, maintain 
      stable HRQoL scores suggesting that surgery may only serve to stabilize HRQoL at 
      2 years.
CI  - (c) 2022. The Author(s), under exclusive licence to Scoliosis Research Society.
FAU - Shaw, K Aaron
AU  - Shaw KA
AUID- ORCID: 0000-0002-3553-2889
AD  - Department of Pediatric Orthopaedic Surgery, Scottish Rite for Children Hospital, 
      Dallas, TX, USA. shaw.aaron82@gmail.com.
FAU - Ramo, Brandon
AU  - Ramo B
AD  - Department of Pediatric Orthopaedic Surgery, Scottish Rite for Children Hospital, 
      Dallas, TX, USA.
FAU - McClung, Anna
AU  - McClung A
AD  - Department of Pediatric Orthopaedic Surgery, Scottish Rite for Children Hospital, 
      Dallas, TX, USA.
FAU - Thornberg, David
AU  - Thornberg D
AD  - Department of Pediatric Orthopaedic Surgery, Scottish Rite for Children Hospital, 
      Dallas, TX, USA.
FAU - Yazsay, Burt
AU  - Yazsay B
AD  - Division of Orthopaedics and Sports Medicine, Seattle Children's Hospital, 
      Seattle, WA, USA.
FAU - Sturm, Peter
AU  - Sturm P
AD  - Department of Pediatric Orthopaedic Surgery, Cincinnati Children's Hospital, 
      Cincinnati, OH, USA.
FAU - Jo, Chan-Hee
AU  - Jo CH
AD  - Department of Pediatric Orthopaedic Surgery, Scottish Rite for Children Hospital, 
      Dallas, TX, USA.
FAU - Oetgen, Matthew E
AU  - Oetgen ME
AD  - Department of Pediatric Orthopaedic Surgery, Children's National Hospital, 
      Washington, DC, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221001
PL  - England
TA  - Spine Deform
JT  - Spine deformity
JID - 101603979
SB  - IM
MH  - Child
MH  - Humans
MH  - Female
MH  - Male
MH  - *Scoliosis/surgery/etiology
MH  - Quality of Life
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Parents
OTO - NOTNLM
OT  - EOSQ
OT  - Early onset scoliosis
OT  - Growth-friendly instrumentation
OT  - Health related quality of life
OT  - Surgery
EDAT- 2022/10/02 06:00
MHDA- 2022/12/23 06:00
CRDT- 2022/10/01 11:17
PHST- 2022/06/01 00:00 [received]
PHST- 2022/08/13 00:00 [accepted]
PHST- 2022/10/02 06:00 [pubmed]
PHST- 2022/12/23 06:00 [medline]
PHST- 2022/10/01 11:17 [entrez]
AID - 10.1007/s43390-022-00572-y [pii]
AID - 10.1007/s43390-022-00572-y [doi]
PST - ppublish
SO  - Spine Deform. 2023 Jan;11(1):213-223. doi: 10.1007/s43390-022-00572-y. Epub 2022 
      Oct 1.