PMID- 36183600
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20231220
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 155
DP  - 2022 Nov
TI  - Relationships between rest-activity rhythms, sleep, and clinical symptoms in 
      individuals at clinical high risk for psychosis and healthy comparison subjects.
PG  - 465-470
LID - S0022-3956(22)00499-X [pii]
LID - 10.1016/j.jpsychires.2022.09.009 [doi]
AB  - Sleep-wake disturbances in individuals at clinical high risk (CHR) of psychosis 
      may relate to increased symptom severity and contribute to disease progression. 
      Here, we examined differences in rest-activity rhythms (RAR) measures, derived 
      from actigraphy, and objective sleep outcomes, derived from 
      electroencephalography (EEG), between 12 CHR and 16 healthy comparison (HC) 
      individuals. Further, we examined the relationships between RAR disturbances, 
      objective sleep outcomes and clinical psychosis symptoms (i.e., negative, 
      positive, disorganized, general symptoms). Sleep-wake behaviors were monitored 
      via actigraphy for 3-7 days (CHR: 5.7 +/- 1.7 days; HC: 6.3 +/- 1.2 days) prior to 
      participants spending a night in the sleep laboratory, which was monitored with 
      EEG. Separate regressions were used to examine the effect of clinical group on 
      RAR measures and objective sleep outcomes after controlling for age and gender. 
      CHR participants were found to be less active, specifically during the evening 
      (17:00-20:00; beta = 1.145, SE = 0.362, p = .004) and nighttime (21:00-24:00; 
      beta = 1.152, SE = 0.326, p = .002) relative to HC. Further, CHR participants had 
      more fragmented sleep (wake after sleep onset: beta = 0.888, SE = 0.395, p = .034) 
      and more hyperarousal during sleep (NREM gamma activity: beta = 1.087, SE = 0.348, 
      p = .005), but these sleep disturbances were not related to reduced activity or 
      clinical symptoms, whereas lower nighttime activity was related to more 
      disorganized symptoms (rho = -.640, p = .025). Thus, increasing activity through 
      behavioral interventions may have additional beneficial effects on CHR clinical 
      symptoms.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - LaGoy, Alice D
AU  - LaGoy AD
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 
      O'Hara Street, Pittsburgh, PA, 15213, USA; Department of Sports Medicine and 
      Nutrition, University of Pittsburgh, 3600 Atwood Street, Pittsburgh, PA, 15260, 
      USA.
FAU - Mayeli, Ahmad
AU  - Mayeli A
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 
      O'Hara Street, Pittsburgh, PA, 15213, USA.
FAU - Smagula, Stephen F
AU  - Smagula SF
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 
      O'Hara Street, Pittsburgh, PA, 15213, USA.
FAU - Ferrarelli, Fabio
AU  - Ferrarelli F
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 
      O'Hara Street, Pittsburgh, PA, 15213, USA. Electronic address: 
      ferrarellif@upmc.edu.
LA  - eng
GR  - R01 MH113827/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220919
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Actigraphy
MH  - Humans
MH  - *Psychotic Disorders/complications/diagnosis
MH  - Rest
MH  - Sleep
MH  - *Sleep Wake Disorders/diagnosis/etiology
PMC - PMC10729940
MID - NIHMS1950193
OTO - NOTNLM
OT  - Actigraphy
OT  - At-risk
OT  - EEG
OT  - Sleep disturbance
COIS- Declaration of competing interest The authors have no conflicts of interest to 
      report.
EDAT- 2022/10/03 06:00
MHDA- 2022/10/19 06:00
PMCR- 2023/12/19
CRDT- 2022/10/02 18:18
PHST- 2022/04/08 00:00 [received]
PHST- 2022/08/11 00:00 [revised]
PHST- 2022/09/12 00:00 [accepted]
PHST- 2022/10/03 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/10/02 18:18 [entrez]
PHST- 2023/12/19 00:00 [pmc-release]
AID - S0022-3956(22)00499-X [pii]
AID - 10.1016/j.jpsychires.2022.09.009 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2022 Nov;155:465-470. doi: 10.1016/j.jpsychires.2022.09.009. 
      Epub 2022 Sep 19.