PMID- 36184363
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221202
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 32
IP  - 12
DP  - 2022 Dec
TI  - A causal relationship between alcohol intake and type 2 diabetes mellitus: A 
      two-sample Mendelian randomization study.
PG  - 2865-2876
LID - S0939-4753(22)00340-4 [pii]
LID - 10.1016/j.numecd.2022.08.013 [doi]
AB  - BACKGROUND AND AIMS: We investigated whether alcohol intake has a causal 
      relationship with type 2 diabetes mellitus (T2DM) risk in adults of the Korean 
      Genomic Epidemiology Study using two-sample Mendelian randomization (MR) 
      analysis. METHODS AND RESULTS: Daily alcohol intake was calculated based on the 
      type, average amount, and frequency of alcohol consumption for six months before 
      the interview. The participants were divided into low- and high-alcohol intake of 
      20 g/day. After adjusting for the covariates related to T2DM, the independent 
      genetic variants (instrumental variables) related to alcohol intake were explored 
      by GWAS analysis in a city hospital-based cohort (n = 58,701). SNPs with a 
      significant level of p-value <5 x 10(-8) and linkage disequilibrium of 
      r(2) < 0.001 were retrieved. MR methods were used to analyze the causality 
      between alcohol intake and the T2DM risk, and the heterogeneity and leave-one-out 
      sensitivity analyses were conducted in Ansan/Ansung plus rural cohorts 
      (n = 13,598). High alcohol intake increased T2DM risk when the inverse-variance 
      weighted (P = 0.012) and weighted median (P = 0.034) methods were used, but not 
      when the MR-Egger method was used. No significant heterogeneity and horizontal 
      pleiotropy between alcohol intake and T2DM were detected. A single genetic 
      variant did not affect the causal association in a leave-one-out sensitivity 
      analysis. CONCLUSION: This study supports that heavy alcohol intake appears to be 
      causally associated with T2DM risk.
CI  - Copyright (c) 2022 The Italian Diabetes Society, the Italian Society for the Study 
      of Atherosclerosis, the Italian Society of Human Nutrition and the Department of 
      Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 
      All rights reserved.
FAU - Liu, Meiling
AU  - Liu M
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, 31499, Republic of Korea.
FAU - Park, Sunmin
AU  - Park S
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, 31499, Republic of Korea. Electronic address: smpark@hoseo.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220817
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Mendelian Randomization Analysis
MH  - Genome-Wide Association Study
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Alcohol Drinking/adverse effects/epidemiology/genetics
OTO - NOTNLM
OT  - Alcohol
OT  - Fat intake
OT  - Genetic variants
OT  - Obesity
OT  - Two-sample Mendelian randomization (MR)
OT  - Type 2 diabetes
COIS- Conflict of interest The authors declare no conflict of interest.
EDAT- 2022/10/03 06:00
MHDA- 2022/11/23 06:00
CRDT- 2022/10/02 22:14
PHST- 2022/03/15 00:00 [received]
PHST- 2022/08/08 00:00 [revised]
PHST- 2022/08/09 00:00 [accepted]
PHST- 2022/10/03 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/10/02 22:14 [entrez]
AID - S0939-4753(22)00340-4 [pii]
AID - 10.1016/j.numecd.2022.08.013 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2022 Dec;32(12):2865-2876. doi: 
      10.1016/j.numecd.2022.08.013. Epub 2022 Aug 17.