PMID- 36185083
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221004
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2022
DP  - 2022
TI  - Effects of Drug-Coated Balloon Therapy on CT Imaging Results and Levels of 
      Vascular Inflammatory Cytokines in Patients with Arteriosclerosis Obliterans 
      Lesions.
PG  - 4793547
LID - 10.1155/2022/4793547 [doi]
LID - 4793547
AB  - OBJECTIVE: The aim of the study is to explore the effects of drug-coated balloon 
      (DCB) therapy on computed tomography (CT) imaging results and levels of vascular 
      inflammatory cytokines in patients with arteriosclerosis obliterans (ASO) 
      lesions. METHODS: A total of 200 patients with ASO lesions admitted to our 
      hospital from January 2021 to December 2021 were enrolled. According to the 
      random number table method, they were divided into observation groups (n = 100) 
      and control groups (n = 100). The observation group was treated with DCB, while 
      the control group was treated with ordinary balloon. At 1 month after surgery, 
      the clinical curative effect was evaluated by ankle-brachial index (ABI). The 
      image quality was compared and vascular patency was evaluated by arterial 
      ultrasound and CT angiography. The minimum luminal diameter (MLD) and late 
      luminal loss (LLL) were recorded. Before and at 1 month after surgery, the 
      severity of disease was assessed by Rutherford grading of lower limb ischemia. 
      Before, at 7 d and 1 month after surgery, inflammatory factors [serum matrix 
      metalloproteinase-9 (MMP-9), monocyte chemoattractant protein-1 (MCP-1), high 
      sensitivity C-reactive protein (hs-CRP), interleukin-4 (IL-4), interleukin-6 
      (IL-6)] were compared between the two groups. The occurrence of postoperative 
      complications was recorded. RESULTS: The clinical response rate in the 
      observation group was significantly higher than that in the control group (97.00% 
      vs 89.00%) (P < 0.05). The restenosis rate in the observation group was 
      significantly lower than that in the control group (1.00% vs 7.00%) (P < 0.05). 
      The MLD in the observation group was significantly longer than that in the 
      control group, and the LLL was significantly lower than that in the control group 
      (P < 0.05). There was no significant difference in image quality between the two 
      groups (P > 0.05). After surgery, disease severity in both groups was relieved, 
      which was milder in the observation group than in the control group (P < 0.05). 
      At 7 d and 1 month after surgery, levels of MMP-9, MCP-1, hs-CRP, IL-4, and IL-6 
      in both groups were decreased, which were lower in the observation group than in 
      the control group (P < 0.05). There was no significant difference in the 
      incidence of complications between the two groups (6.00% vs 7.00%) (P > 0.05). 
      CONCLUSION: The curative effect of DCB is good on patients with ASO lesions, 
      which can reduce the restenosis rate, control luminal loss, relieve inflammatory 
      response, and improve disease severity.
CI  - Copyright (c) 2022 Yanlin Yang.
FAU - Yang, Yanlin
AU  - Yang Y
AUID- ORCID: 0000-0002-0173-8117
AD  - Department of Interventional Radiology, Harrison International Peace Hospital, 
      Hengshui, Hebei 053000, China.
LA  - eng
PT  - Journal Article
DEP - 20220922
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC9522490
COIS- The authors declare that they have no conflicts of interest, financially or 
      otherwise.
EDAT- 2022/10/04 06:00
MHDA- 2022/10/04 06:01
PMCR- 2022/09/22
CRDT- 2022/10/03 04:14
PHST- 2022/07/28 00:00 [received]
PHST- 2022/08/30 00:00 [accepted]
PHST- 2022/10/03 04:14 [entrez]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/10/04 06:01 [medline]
PHST- 2022/09/22 00:00 [pmc-release]
AID - 10.1155/2022/4793547 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2022 Sep 22;2022:4793547. doi: 
      10.1155/2022/4793547. eCollection 2022.