PMID- 36185474
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221004
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - Prediction value of the genetic risk of type 2 diabetes on the amnestic mild 
      cognitive impairment conversion to Alzheimer's disease.
PG  - 964463
LID - 10.3389/fnagi.2022.964463 [doi]
LID - 964463
AB  - Amnestic mild cognitive impairment (aMCI) and Type 2 diabetes mellitus (T2DM) are 
      both important risk factors for Alzheimer's disease (AD). We aimed to investigate 
      whether a T2DM-specific polygenic risk score (PRS (sT2DM) ) can predict the 
      conversion of aMCI to AD and further explore the underlying neurological 
      mechanism. All aMCI patients were from the Alzheimer's disease Neuroimaging 
      Initiative (ADNI) database and were divided into conversion (aMCI-C, n = 164) and 
      stable (aMCI-S, n = 222) groups. PRS (sT2DM) was calculated by PRSice-2 software 
      to explore the predictive efficacy of the aMCI conversion to AD. We found that 
      PRS (sT2DM) could independently predict the aMCI conversion to AD after removing 
      the common variants of these two diseases. PRS (sT2DM) was significantly 
      negatively correlated with gray matter volume (GMV) of the right superior frontal 
      gyrus in the aMCI-C group. In all aMCI patients, PRS (sT2DM) was significantly 
      negatively correlated with the cortical volume of the right superior occipital 
      gyrus. The cortical volume of the right superior occipital gyrus could 
      significantly mediate the association between PRS (sT2DM) and aMCI conversion. 
      Gene-based analysis showed that T2DM-specific genes are highly expressed in 
      cortical neurons and involved in ion and protein binding, neural development and 
      generation, cell junction and projection, and PI3K-Akt and MAPK signaling 
      pathway, which might increase the aMCI conversion by affecting the Tau 
      phosphorylation and amyloid-beta (Abeta) accumulation. Therefore, the PRS (sT2DM) 
      could be used as a measure to predict the conversion of aMCI to AD.
CI  - Copyright (c) 2022 Yang, Wang, Fu, Xu, Zhang, Qin and Zhang.
FAU - Yang, Jiayang
AU  - Yang J
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
FAU - Wang, Zirui
AU  - Wang Z
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
FAU - Fu, Yumeng
AU  - Fu Y
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
FAU - Xu, Jiayuan
AU  - Xu J
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
FAU - Qin, Wen
AU  - Qin W
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
FAU - Zhang, Quan
AU  - Zhang Q
AD  - Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, 
      Tianjin Medical University General Hospital, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20220915
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9521369
OTO - NOTNLM
OT  - cortical volume
OT  - gray matter volume
OT  - magnetic resonance imaging
OT  - mediation analysis
OT  - polygenic risk score
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/04 06:00
MHDA- 2022/10/04 06:01
PMCR- 2022/01/01
CRDT- 2022/10/03 04:20
PHST- 2022/06/09 00:00 [received]
PHST- 2022/08/23 00:00 [accepted]
PHST- 2022/10/03 04:20 [entrez]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/10/04 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.964463 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Sep 15;14:964463. doi: 10.3389/fnagi.2022.964463. 
      eCollection 2022.