PMID- 36185686
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221004
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Association of cluster determinant 36, scavenger receptor class B type 1, and 
      major facilitator superfamily domain containing the 2a genetic polymorphism with 
      serum lipid profile in aging population with type 2 diabetes mellitus.
PG  - 981200
LID - 10.3389/fnut.2022.981200 [doi]
LID - 981200
AB  - BACKGROUND: Lipid metabolism disorder commonly happens in subjects with Type 2 
      diabetes mellitus (T2DM) which may be linked to genetic variants of lipid 
      metabolism-related genes. However, few studies have explored the relationship 
      between lipid metabolism-related gene polymorphism and serum lipid profile in 
      aging subjects with T2DM. The present study was designed to explore the impact of 
      genetic polymorphism of cluster determinant 36 (CD36) (rs1049673, rs1054516, 
      rs2151916), scavenger receptor class B type 1 (SCARB1) (rs5888), and major 
      facilitator superfamily domain containing the 2a (MFSD2A) (rs12083239, rs4233508, 
      rs12072037) on the relationship between circulating lipids in aging subjects with 
      T2DM. METHODS: 205 T2DM patients and 205 age and gender matched control subjects 
      were recruited. Information on demographic characteristics was collected by using 
      a self-administered questionnaire. Fasting venous blood samples were taken for 
      lipid-related gene genotyping and serum lipid profile measurement. The Chi-square 
      test was used to compare percentage differences and to calculate P-value for 
      Hardy-Weinberg equilibrium. Logistic regression and multiple linear regression 
      were used to explore the risk or correlation between variables, and general 
      linear model (GLM) was used to compare the means of serum lipids between the 
      groups. RESULTS: In T2DM group, CD36 rs1054516 and MFSD2A rs12072037 were 
      correlated with serum TC level. In control group, CD36 rs1049673 was correlated 
      with serum HDL-C level. Meanwhile, T2DM subjects with MFSD2A rs12083239 (CG), 
      MFSD2A rs4233508 (TT), and MFSD2A rs12072037 (AA) had higher TG level than 
      control subjects. T2DM subjects with CD36 rs1049673 (CG, GG), CD36 rs1054516 
      (CT), CD36 rs2151916 (TT, CT), SCARB1 rs5888 (GG), MFSD2A rs12083239 (GG, CG), 
      MFSD2A rs4233508 (TT), and MFSD2A rs12072037 (CA, AA) had lower HDL-C level than 
      control subjects. T2DM subjects with MFSD2A rs12072037 (AA) had lower LDL-C level 
      than control subjects. In dominant model, major genotype (GG) of SCARB1 gene was 
      associated with the risk of T2DM (OR = 0.636, P = 0.032). CONCLUSION: The genetic 
      polymorphism of CD36 (rs1049673, rs1054516, rs2151916), SCARB1 (rs5888), and 
      MFSD2A (rs12083239, rs4233508, rs12072037) were associated with serum lipids in 
      T2DM subjects. The SCARB1 rs5888 major genotype (GG) was a protective factor for 
      T2DM. Large scale cohort study is required to determine the relationship between 
      lipid metabolism-related gene polymorphism, serum lipid profile and T2DM in aging 
      subjects.
CI  - Copyright (c) 2022 Wang, Ma, Xu, Guo, Zhou, Yu and Yuan.
FAU - Wang, Xixiang
AU  - Wang X
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Ma, Xiaojun
AU  - Ma X
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Xu, Jingjing
AU  - Xu J
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Guo, Yujie
AU  - Guo Y
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Zhou, Shaobo
AU  - Zhou S
AD  - School of Science, Faculty of Engineering and Science, University of Greenwich, 
      Chatham, United Kingdom.
FAU - Yu, Huiyan
AU  - Yu H
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Yuan, Linhong
AU  - Yuan L
AD  - School of Public Health, Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220914
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9515475
OTO - NOTNLM
OT  - genetic polymorphism
OT  - lipid metabolism-related gene
OT  - serum lipid profile
OT  - the elderly
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/04 06:00
MHDA- 2022/10/04 06:01
PMCR- 2022/01/01
CRDT- 2022/10/03 04:23
PHST- 2022/06/29 00:00 [received]
PHST- 2022/08/23 00:00 [accepted]
PHST- 2022/10/03 04:23 [entrez]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/10/04 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.981200 [doi]
PST - epublish
SO  - Front Nutr. 2022 Sep 14;9:981200. doi: 10.3389/fnut.2022.981200. eCollection 
      2022.