PMID- 36186852
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221004
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - Mapping structural covariance networks in children and adolescents with 
      post-traumatic stress disorder after earthquake.
PG  - 923572
LID - 10.3389/fpsyt.2022.923572 [doi]
LID - 923572
AB  - For children and adolescents, there is a high risk of developing post-traumatic 
      stress disorder (PTSD) after suffering from catastrophic events. Previous studies 
      have identified brain functionally and subcortical brain volumes structurally 
      abnormalities in this population. However, up till now, researches exploring 
      alterations of regional cortical thickness (CTh) and brain interregional 
      structural covariance networks (SCNs) are scarce. In this cross-sectional study, 
      CTh measures are derived from 3-Tesla Tl-weighted MRI imaging data in a 
      well-characterized combined group of children and adolescents with PTSD after an 
      earthquake (N = 35) and a traumatized healthy control group (N = 24). By using 
      surface-based morphometry (SBM) techniques, the regional CTh analysis was 
      conducted. To map interregional SCNs derived from CTh, twenty-five altered brain 
      regions reported in the PTSD population were selected as seeds. Whole-brain SBM 
      analysis discovered a significant thickness reduction in the left medial 
      orbitofrontal cortex for the subjects with PTSD. Similarly, analysis of SCNs 
      associated with "seed" regions primarily located in default mode network (DMN), 
      midline cortex structures, motor cortex, auditory association cortex, limbic 
      system, and visual cortex demonstrated that children and adolescents with PTSD 
      are associated with altered structural covariance with six key regions. This 
      study provides evidence for distinct CTh correlates of PTSD that are present 
      across children and adolescents, suggesting that brain cortical abnormalities 
      related to trauma exposure are present in this population, probably by driving 
      specific symptom clusters associated with disrupted extinction recall mechanisms 
      for fear, episodic memory network and visuospatial attention.
CI  - Copyright (c) 2022 Mo, He, Zhou, Liu, Zhu, Huang, Zeng, Zhang and Li.
FAU - Mo, Xian
AU  - Mo X
AD  - College of Electrical Engineering, Sichuan University, Chengdu, Sichuan, China.
AD  - Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan, China.
FAU - He, Meirong
AU  - He M
AD  - College of Electrical Engineering, Sichuan University, Chengdu, Sichuan, China.
FAU - Zhou, Lijun
AU  - Zhou L
AD  - College of Electrical Engineering, Sichuan University, Chengdu, Sichuan, China.
FAU - Liu, Yunfei
AU  - Liu Y
AD  - College of Electrical Engineering, Sichuan University, Chengdu, Sichuan, China.
FAU - Zhu, Hongru
AU  - Zhu H
AD  - Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan, China.
AD  - Mental Health Center and Psychiatric Laboratory, West China Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Huang, Xiaoqi
AU  - Huang X
AD  - West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Zeng, Guojun
AU  - Zeng G
AD  - West China Hospital, Sichuan University, Chengdu, Sichuan, China.
FAU - Zhang, Junran
AU  - Zhang J
AD  - College of Electrical Engineering, Sichuan University, Chengdu, Sichuan, China.
AD  - Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan, China.
FAU - Li, Lingjiang
AU  - Li L
AD  - Department of Psychiatry, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20220915
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC9520616
OTO - NOTNLM
OT  - children and adolescents
OT  - connectivity
OT  - cortical thickness
OT  - magnetic resonance imaging
OT  - post-traumatic stress disorder
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/10/04 06:00
MHDA- 2022/10/04 06:01
PMCR- 2022/09/15
CRDT- 2022/10/03 04:41
PHST- 2022/04/19 00:00 [received]
PHST- 2022/08/29 00:00 [accepted]
PHST- 2022/10/03 04:41 [entrez]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/10/04 06:01 [medline]
PHST- 2022/09/15 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.923572 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 Sep 15;13:923572. doi: 10.3389/fpsyt.2022.923572. 
      eCollection 2022.