PMID- 36189910
OWN - NLM
STAT- MEDLINE
DCOM- 20230505
LR  - 20240102
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 41
IP  - 5
DP  - 2023 May
TI  - Progression and prognosis of interstitial pneumonia with autoimmune features: a 
      longitudinal, prospective, multi-centre study.
PG  - 1140-1148
LID - 10.55563/clinexprheumatol/lycdca [doi]
AB  - OBJECTIVES: To evaluate the rate of progression towards specific autoimmune 
      diseases (SADs) of a prospective, multi-centre cohort of patients classifiable as 
      interstitial pneumonia with autoimmune features (IPAF). METHODS: IPAF patients 
      were enrolled based on specific research criteria, and jointly followed by 
      rheumatologists and pulmonologists for at least one year with clinical check-ups, 
      serological exams including autoimmunity, capillaroscopy and high-resolution 
      computed tomography (HRCT). Diagnostic assessment was repeated at least once a 
      year, or earlier when deemed useful. RESULTS: We enrolled 191 IPAF patients 
      through 95 different combinations of IPAF criteria. Of these, 24.1% progressed 
      towards SAD, mainly in connective tissue diseases but also in microscopic 
      polyangiitis. The IPAF patients who progressed were younger than stable IPAF 
      patients (63+/-10 years vs. 68+/-9 years, p=0.002) and had a longer follow-up 
      (36.9+/-18.7 vs. 29.3+/-15.7 months, p=0.007), but similar severity. No parameters 
      were associated with overall progression, but some parameters were associated 
      with the development of specific diagnoses: Sjogren's syndrome with positivity 
      for SSA (p=0.007, chi2 7.4); idiopathic inflammatory myopathy with mechanic's hands 
      (p=<0.0001, chi2 12.6), organizing pneumonia pattern (p=0.01, chi2 6.1), positivity 
      for anti-Pm/scl (p=0.04 chi2 4.1) and anti-MDA5 (p=0.04, chi2 4.2); systemic 
      sclerosis with palmar telangiectasias (p=<0.0001 2 18.3), positivity for 
      anti-Scl70 (p=<0.0001 chi2 12.5) and anti-PM/Scl (p=0.001 chi2 10.1). CONCLUSIONS: 
      IPAF patients had a rate of progression towards SAD similar to that reported in 
      previous studies on undifferentiated connective tissue diseases, thus including 
      some patients in which lung involvement could represent the first or even the 
      sole clinical manifestation of a SAD.
FAU - Sambataro, Gianluca
AU  - Sambataro G
AD  - Regional Referral Centre for Rare Lung Disease, A.O.U. Policlinico G.Rodolico-San 
      Marco, University of Catania, and Artroreuma srl, Outpatient Clinic of 
      Rheumatology, Mascalucia, Catania, Italy. dottorsambataro@gmail.com.
FAU - Sambataro, Domenico
AU  - Sambataro D
AD  - Artroreuma srl, Outpatient Clinic of Rheumatology, Mascalucia, Catania, and 
      Department of Clinical and Experimental Medicine, Internal Medicine Unit, 
      Division of Rheumatology, Cannizzaro Hospital, University of Catania, Italy.
FAU - Spicuzza, Lucia
AU  - Spicuzza L
AD  - Regional Referral Centre for Rare Lung Disease, A.O.U. Policlinico G.Rodolico-San 
      Marco, University of Catania, Italy.
FAU - Meloni, Federica
AU  - Meloni F
AD  - Department of Internal Medicine and Therapeutics, U.O.S. Transplant Center, 
      Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy.
FAU - Lorini, Giorgio
AU  - Lorini G
AD  - Department of Internal Medicine and Therapeutics, U.O.S. Transplant Center, 
      Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy.
FAU - Malatino, Lorenzo
AU  - Malatino L
AD  - Department of Clinical and Experimental Medicine, Internal Medicine Unit, 
      Division of Rheumatology, Cannizzaro Hospital, University of Catania, Italy.
FAU - Colaci, Michele
AU  - Colaci M
AD  - Department of Clinical and Experimental Medicine, Internal Medicine Unit, 
      Division of Rheumatology, Cannizzaro Hospital, University of Catania, Italy.
FAU - Sebastiani, Giandomenico
AU  - Sebastiani G
AD  - U.O.C. Reumatologia, A.O. San Camillo-Forlanini, Roma, Italy.
FAU - Iuliano, Annamaria
AU  - Iuliano A
AD  - U.O.C. Reumatologia, A.O. San Camillo-Forlanini, Roma, Italy.
FAU - Canofari, Claudia
AU  - Canofari C
AD  - U.O.C. Reumatologia, A.O. San Camillo-Forlanini, Roma, Italy.
FAU - Luppi, Fabrizio
AU  - Luppi F
AD  - Respiratory Diseases Unit, San Gerardo Hospital, Monza University of 
      Milano-Bicocca, Italy.
FAU - Franco, Giovanni
AU  - Franco G
AD  - Respiratory Diseases Unit, San Gerardo Hospital, Monza University of 
      Milano-Bicocca, Italy.
FAU - Zanini, Umberto
AU  - Zanini U
AD  - Respiratory Diseases Unit, San Gerardo Hospital, Monza University of 
      Milano-Bicocca, Italy.
FAU - Manfredi, Andreina
AU  - Manfredi A
AD  - Rheumatology Unit, Azienda Policlinico di Modena, University of Modena and Reggio 
      Emilia, Modena, Italy.
FAU - Gozzi, Filippo
AU  - Gozzi F
AD  - Respiratory Disease Unit, Azienda Policlinico di Modena, University of Modena and 
      Reggio Emilia, Modena, Italy.
FAU - Sebastiani, Marco
AU  - Sebastiani M
AD  - Rheumatology Unit, Azienda Policlinico di Modena, University of Modena and Reggio 
      Emilia, Modena, Italy.
FAU - Palmucci, Stefano
AU  - Palmucci S
AD  - Department of Medical-Surgical Sciences and Advanced Technologies G.F. Ingrassia, 
      Radiology I Unit, University Hospital Policlinico G. Rodolico-San Marco, Catania, 
      Italy.
FAU - Cavagna, Lorenzo
AU  - Cavagna L
AD  - Department of Internal Medicine and Therapeutics, Division of Rheumatology, 
      Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy.
FAU - Vancheri, Carlo
AU  - Vancheri C
AD  - Regional Referral Centre for Rare Lung Disease, A.O.U. Policlinico G. 
      Rodolico-San Marco, University of Catania, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20221003
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - *Lung Diseases, Interstitial/diagnostic imaging/etiology
MH  - *Autoimmune Diseases/diagnostic imaging/complications
MH  - *Connective Tissue Diseases/diagnosis/diagnostic imaging
MH  - Prognosis
EDAT- 2022/10/04 06:00
MHDA- 2023/05/05 06:42
CRDT- 2022/10/03 06:42
PHST- 2022/07/08 00:00 [received]
PHST- 2022/09/19 00:00 [accepted]
PHST- 2023/05/05 06:42 [medline]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/10/03 06:42 [entrez]
AID - 18966 [pii]
AID - 10.55563/clinexprheumatol/lycdca [doi]
PST - ppublish
SO  - Clin Exp Rheumatol. 2023 May;41(5):1140-1148. doi: 
      10.55563/clinexprheumatol/lycdca. Epub 2022 Oct 3.