PMID- 36191484 OWN - NLM STAT- MEDLINE DCOM- 20221013 LR - 20230120 IS - 1873-6750 (Electronic) IS - 0160-4120 (Print) IS - 0160-4120 (Linking) VI - 169 DP - 2022 Nov TI - Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy. PG - 107541 LID - S0160-4120(22)00468-8 [pii] LID - 10.1016/j.envint.2022.107541 [doi] AB - BACKGROUND: Oxidative stress from excess reactive oxygen species (ROS) is a hypothesized contributor to preterm birth. Per- and polyfluoroalkyl substances (PFAS) exposure is reported to generate ROS in laboratory settings, and is linked to adverse birth outcomes globally. However, to our knowledge, the relationship between PFAS and oxidative stress has not been examined in the context of human pregnancy. OBJECTIVE: To investigate the associations between prenatal PFAS exposure and oxidative stress biomarkers among pregnant people. METHODS: Our analytic sample included 428 participants enrolled in the Illinois Kids Development Study and Chemicals In Our Bodies prospective birth cohorts between 2014 and 2019. Twelve PFAS were measured in second trimester serum. We focused on seven PFAS that were detected in >65 % of participants. Urinary levels of 8-isoprostane-prostaglandin-F(2alpha), prostaglandin-F(2alpha), 2,3-dinor-8-iso-PGF(2alpha), and 2,3-dinor-5,6-dihydro-8-iso-PGF(2alpha) were measured in the second and third trimesters as biomarkers of oxidative stress. We fit linear mixed-effects models to estimate individual associations between PFAS and oxidative stress biomarkers. We used quantile g-computation and Bayesian kernel machine regression (BKMR) to assess associations between the PFAS mixture and averaged oxidative stress biomarkers. RESULTS: Linear mixed-effects models showed that an interquartile range increase in perfluorooctane sulfonic acid (PFOS) was associated with an increase in 8-isoprostane-prostaglandin-F(2alpha) (beta = 0.10, 95 % confidence interval = 0, 0.20). In both quantile g-computation and BKMR, and across all oxidative stress biomarkers, PFOS contributed the most to the overall mixture effect. The six remaining PFAS were not significantly associated with changes in oxidative stress biomarkers. CONCLUSIONS: Our study is the first to investigate the relationship between PFAS exposure and biomarkers of oxidative stress during human pregnancy. We found that PFOS was associated with elevated levels of oxidative stress, which is consistent with prior work in animal models and cell lines. Future research is needed to understand how prenatal PFAS exposure and maternal oxidative stress may affect fetal development. CI - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Taibl, Kaitlin R AU - Taibl KR AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Schantz, Susan AU - Schantz S AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL USA; Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Champaign, IL, USA. FAU - Aung, Max T AU - Aung MT AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. FAU - Padula, Amy AU - Padula A AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Geiger, Sarah AU - Geiger S AD - Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL USA; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA. FAU - Smith, Sabrina AU - Smith S AD - Environmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA. FAU - Park, June-Soo AU - Park JS AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA; Environmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA, USA. FAU - Milne, Ginger L AU - Milne GL AD - Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. FAU - Robinson, Joshua F AU - Robinson JF AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Woodruff, Tracey J AU - Woodruff TJ AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA. FAU - Morello-Frosch, Rachel AU - Morello-Frosch R AD - Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA; Department of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, Berkeley, CA, USA. FAU - Eick, Stephanie M AU - Eick SM AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: stephanie.marie.eick@emory.edu. LA - eng GR - P01 ES022841/ES/NIEHS NIH HHS/United States GR - U2C OD023375/OD/NIH HHS/United States GR - R01 ES027051/ES/NIEHS NIH HHS/United States GR - UG3 OD023272/OD/NIH HHS/United States GR - P30 ES030284/ES/NIEHS NIH HHS/United States GR - P30 ES019776/ES/NIEHS NIH HHS/United States GR - P01 ES022848/ES/NIEHS NIH HHS/United States GR - UH3 OD023272/OD/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20220927 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Alkanesulfonic Acids) RN - 0 (Biomarkers) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) RN - 0 (Reactive Oxygen Species) RN - 142620-95-9 (S-(2-(N,N-diisopropylamino)ethyl)isothiourea) RN - 9H2MAI21CL (perfluorooctane sulfonic acid) RN - ZZQ699148P (Dimaprit) SB - IM MH - *Alkanesulfonic Acids/toxicity MH - Animals MH - Bayes Theorem MH - Biomarkers MH - Dimaprit/analogs & derivatives MH - *Environmental Pollutants/adverse effects MH - Female MH - *Fluorocarbons/toxicity MH - Humans MH - Infant, Newborn MH - Oxidative Stress MH - Pregnancy MH - *Premature Birth/chemically induced MH - Prospective Studies MH - Reactive Oxygen Species PMC - PMC9846434 MID - NIHMS1864025 OTO - NOTNLM OT - Maternal and child health OT - Mixtures OT - Oxidative stress OT - PFAS COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/10/04 06:00 MHDA- 2022/10/14 06:00 PMCR- 2023/01/18 CRDT- 2022/10/03 18:24 PHST- 2022/06/01 00:00 [received] PHST- 2022/09/21 00:00 [revised] PHST- 2022/09/22 00:00 [accepted] PHST- 2022/10/04 06:00 [pubmed] PHST- 2022/10/14 06:00 [medline] PHST- 2022/10/03 18:24 [entrez] PHST- 2023/01/18 00:00 [pmc-release] AID - S0160-4120(22)00468-8 [pii] AID - 10.1016/j.envint.2022.107541 [doi] PST - ppublish SO - Environ Int. 2022 Nov;169:107541. doi: 10.1016/j.envint.2022.107541. Epub 2022 Sep 27.