PMID- 36191821
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20221129
IS  - 1879-0461 (Electronic)
IS  - 1040-8428 (Linking)
VI  - 180
DP  - 2022 Dec
TI  - Corticosteroids in oncology: Use, overuse, indications, contraindications. An 
      Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical 
      Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of 
      Pharmacology (SIF) multidisciplinary consensus position paper.
PG  - 103826
LID - S1040-8428(22)00250-5 [pii]
LID - 10.1016/j.critrevonc.2022.103826 [doi]
AB  - Corticosteroids (CSs) are widely used in oncology, presenting several different 
      indications. They are useful for induction of apoptosis in hematological 
      neoplasms, for management of anaphylaxis and cytokine release/hypersensitivity 
      reaction and for the symptomatic treatment of many tumour- and treatment-related 
      complications. If the employment of CSs in the oncological setting results in 
      several benefits for patients and satisfaction for clinicians, on the other hand, 
      many potential adverse events (AEs), both during treatment and after withdrawal 
      of CSs, as well as the duality of the effects of these compounds in oncology, 
      recommend being cautious in clinical practice. To date, several gray zones remain 
      about indications, contraindications, dose, and duration of treatment. In this 
      article, a panel of experts provides a critical review on CSs therapy in 
      oncology, focusing on mechanisms of action and pharmacological characteristics, 
      current and emerging therapeutic indications/contraindications, AEs related to 
      CSs treatment, and the impact on patient outcome.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Faggiano, Antongiulio
AU  - Faggiano A
AD  - Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea 
      Hospital, ENETS Center of Excellence, Sapienza University of Rome, Rome, Italy. 
      Electronic address: antongiulio.faggiano@uniroma1.it.
FAU - Mazzilli, Rossella
AU  - Mazzilli R
AD  - Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea 
      Hospital, ENETS Center of Excellence, Sapienza University of Rome, Rome, Italy.
FAU - Natalicchio, Annalisa
AU  - Natalicchio A
AD  - Department of Emergency and Organ Transplantation, Section of Internal Medicine, 
      Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 
      Bari, Italy.
FAU - Adinolfi, Valerio
AU  - Adinolfi V
AD  - Endocrinology and Diabetology Unit, ASL Verbano Cusio Ossola, Domodossola, Italy.
FAU - Argentiero, Antonella
AU  - Argentiero A
AD  - Medical Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
FAU - Danesi, Romano
AU  - Danesi R
AD  - Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and 
      Experimental Medicine, University of Pisa, Pisa, Italy.
FAU - D'Oronzo, Stella
AU  - D'Oronzo S
AD  - Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Bari, 
      Italy.
FAU - Fogli, Stefano
AU  - Fogli S
AD  - Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and 
      Experimental Medicine, University of Pisa, Pisa, Italy.
FAU - Gallo, Marco
AU  - Gallo M
AD  - Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo 
      of Alessandria, Alessandria, Italy.
FAU - Giuffrida, Dario
AU  - Giuffrida D
AD  - Department of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, Catania, 
      Italy.
FAU - Gori, Stefania
AU  - Gori S
AD  - Oncologia Medica, IRCCS Ospedale Don Calabria-Sacro Cuore di Negrar, Verona, 
      Italy.
FAU - Montagnani, Monica
AU  - Montagnani M
AD  - Department of Biomedical Sciences and Human Oncology - Section of Pharmacology, 
      Medical School - University of Bari Aldo Moro, Bari, Italy.
FAU - Ragni, Alberto
AU  - Ragni A
AD  - Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo 
      of Alessandria, Alessandria, Italy.
FAU - Renzelli, Valerio
AU  - Renzelli V
AD  - Diabetologist and Endocrinologist, Italian Association of Clinical 
      Diabetologists, Italy.
FAU - Russo, Antonio
AU  - Russo A
AD  - Department of Surgical, Oncological and Oral Sciences, Section of Medical 
      Oncology, University of Palermo, Palermo, Italy.
FAU - Silvestris, Nicola
AU  - Silvestris N
AD  - Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of 
      Messina, Messina, Italy.
FAU - Franchina, Tindara
AU  - Franchina T
AD  - Medical Oncology Unit, Department of Human Pathology "G. Barresi", University of 
      Messina, Messina, Italy.
FAU - Tuveri, Enzo
AU  - Tuveri E
AD  - Diabetology, Endocrinology and Metabolic Diseases Service, ASL-Sulcis, Italy.
FAU - Cinieri, Saverio
AU  - Cinieri S
AD  - Medical Oncology Division and Breast Unit, Senatore Antonio Perrino Hospital, ASL 
      Brindisi, Brindisi, Italy.
FAU - Colao, Annamaria
AU  - Colao A
AD  - Endocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine 
      and Surgery, Federico II University of Naples, Naples, Italy; UNESCO Chair, 
      Education for Health and Sustainable Development, Federico II University, Naples, 
      Italy.
FAU - Giorgino, Francesco
AU  - Giorgino F
AD  - Department of Emergency and Organ Transplantation, Section of Internal Medicine, 
      Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 
      Bari, Italy.
FAU - Zatelli, Maria Chiara
AU  - Zatelli MC
AD  - Section of Endocrinology and Internal Medicine, Department of Medical Sciences, 
      University of Ferrara, Italy.
CN  - Oncological Endocrinology research group of the Italian Society of Endocrinology
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220930
PL  - Netherlands
TA  - Crit Rev Oncol Hematol
JT  - Critical reviews in oncology/hematology
JID - 8916049
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Humans
MH  - Consensus
MH  - *Medical Oncology/methods
MH  - *Societies, Medical
MH  - Contraindications
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Italy
OTO - NOTNLM
OT  - Adverse events
OT  - Cancer
OT  - Corticosteroids
OT  - Dose
OT  - Glucocorticoids
OT  - Indications
OT  - Survival
OT  - Tumour response
EDAT- 2022/10/04 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/10/03 19:27
PHST- 2022/08/04 00:00 [received]
PHST- 2022/09/28 00:00 [revised]
PHST- 2022/09/28 00:00 [accepted]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/10/03 19:27 [entrez]
AID - S1040-8428(22)00250-5 [pii]
AID - 10.1016/j.critrevonc.2022.103826 [doi]
PST - ppublish
SO  - Crit Rev Oncol Hematol. 2022 Dec;180:103826. doi: 
      10.1016/j.critrevonc.2022.103826. Epub 2022 Sep 30.