PMID- 36192550
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20221024
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 239
IP  - 11
DP  - 2022 Nov
TI  - The nucleus accumbens dopamine increase, typically triggered by sexual stimuli in 
      male rats, is no longer produced when animals are sexually inhibited due to 
      sexual satiety.
PG  - 3679-3695
LID - 10.1007/s00213-022-06240-3 [doi]
AB  - RATIONALE: Exposure of male rats to an inaccessible receptive female and 
      copulation increases dopamine (DA) levels in the nucleus accumbens (NAcc). Males 
      copulating to satiety become sexually inhibited and most of them do not display 
      sexual activity when presented with a sexually receptive female 24 h later. This 
      inhibitory state can be pharmacologically reversed. There are no studies 
      exploring NAcc DA levels during this sexual inhibitory state. OBJECTIVES: To 
      characterize changes in NAcc DA and its metabolites' levels during sexual satiety 
      development, during the well-established sexual inhibitory state 24 h later, and 
      during its pharmacological reversal. METHODS: Changes in NAcc DA and its 
      metabolites were measured in sexually experienced male rats, using in vivo 
      microdialysis, during copulation to satiety, when presented to a new sexually 
      receptive female 24 h later, and during the pharmacological reversal of the 
      sexual inhibition by anandamide. RESULTS: NAcc DA levels remained increased 
      during copulation to satiety. DA basal levels were significantly reduced 24 h 
      after copulation to satiety, as compared to the initial basal levels. Presenting 
      a receptive female behind a barrier 24 h after satiety did not induce the typical 
      NAcc DA elevation in the sexually satiated males but there was a decrease that 
      persisted when they got access to the female, with which they did not copulate. 
      Anandamide injection slightly increased NAcc DA levels coinciding with sexual 
      satiety reversal. CONCLUSIONS: Reduced NAcc DA concentrations coincide with the 
      inhibition of an instinctive, natural rewarding behavior suggesting that there 
      might be a DA concentration threshold needed to be responsive to a rewarding 
      stimulus.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Canseco-Alba, Ana
AU  - Canseco-Alba A
AD  - Direccion de Investigacion, Instituto Nacional de Neurologia y Neurocirugia 
      "Manuel Velasco Suarez, " Av. Insurgentes Sur 3877, Col. La Fama, 14269, Mexico 
      City, Mexico. ana.canseco@innn.edu.mx.
FAU - Coffeen, Ulises
AU  - Coffeen U
AD  - Direccion de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatria 
      "Ramon de La Fuente Muniz, Mexico City, Mexico.
FAU - Jaimes, Orlando
AU  - Jaimes O
AD  - Direccion de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatria 
      "Ramon de La Fuente Muniz, Mexico City, Mexico.
FAU - Pellicer, Francisco
AU  - Pellicer F
AD  - Direccion de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatria 
      "Ramon de La Fuente Muniz, Mexico City, Mexico.
FAU - Rodriguez-Manzo, Gabriela
AU  - Rodriguez-Manzo G
AUID- ORCID: 0000-0002-5960-7566
AD  - Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados 
      (Cinvestav-Sede Sur), Calzada de los Tenorios 235, Col. Granjas Coapa, 14330, 
      Mexico City, Mexico. grodrigu@cinvestav.mx.
LA  - eng
GR  - 220772/WT_/Wellcome Trust/United Kingdom
GR  - 220772/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20221003
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - VTD58H1Z2X (Dopamine)
RN  - UR5G69TJKH (anandamide)
RN  - 0 (Endocannabinoids)
SB  - IM
MH  - Rats
MH  - Male
MH  - Female
MH  - Animals
MH  - *Nucleus Accumbens/metabolism
MH  - *Dopamine/metabolism
MH  - Sexual Behavior, Animal/physiology
MH  - Endocannabinoids/metabolism
OTO - NOTNLM
OT  - Anandamide
OT  - Dopamine extracellular concentrations
OT  - Male sexual behavior
OT  - Mesolimbic system
OT  - Microdialysis
OT  - Natural reward
OT  - Nucleus accumbens
OT  - Sexual inhibition
OT  - Sexual motivation
OT  - Sexual satiety
EDAT- 2022/10/04 06:00
MHDA- 2022/10/25 06:00
CRDT- 2022/10/03 23:29
PHST- 2022/07/19 00:00 [received]
PHST- 2022/09/17 00:00 [accepted]
PHST- 2022/10/04 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/10/03 23:29 [entrez]
AID - 10.1007/s00213-022-06240-3 [pii]
AID - 10.1007/s00213-022-06240-3 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2022 Nov;239(11):3679-3695. doi: 
      10.1007/s00213-022-06240-3. Epub 2022 Oct 3.