PMID- 3619293
OWN - NLM
STAT- MEDLINE
DCOM- 19870921
LR  - 20170214
IS  - 0003-4894 (Print)
IS  - 0003-4894 (Linking)
VI  - 96
IP  - 4
DP  - 1987 Jul-Aug
TI  - Effect of glycerol on inner ear fluid electrolytes and osmolalities in guinea 
      pigs.
PG  - 461-7
AB  - Endolymph of the scala media (SM) and perilymph of the scala vestibuli (SV) and 
      scala tympani (ST) were collected from the basal turn of anesthetized guinea pigs 
      before and after intravenous administration of glycerol (3 g/kg). Sound-evoked 
      responses were recorded during the test periods. Blood, CSF, and perilymph of the 
      ST were also collected continuously after the injection. The osmolalities and 
      chloride concentrations of the collected samples were determined. In another 
      experiment, the continuous changes of potassium and chloride concentrations in 
      endolymph and perilymph of the ST before and after the injection were measured by 
      ion-selective electrodes. The osmolalities in CSF and perilymph lagged behind the 
      increase in serum osmolality. The osmolalities in endolymph and perilymph 
      increased gradually after the injection, reached maximum values after 90 minutes, 
      and then decreased. The changes in chloride and potassium concentrations in 
      endolymph and perilymph had similar tendencies. But the increases in chloride 
      concentrations in perilymph of the SV and ST were much less than that in 
      endolymph. We propose that most of the osmolality increase in perilymph is due to 
      glycerol or other osmotically active substances and that the osmolality increase 
      in endolymph is due to water shift.
FAU - Ueda, H
AU  - Ueda H
FAU - Muratsuka, Y
AU  - Muratsuka Y
FAU - Konishi, T
AU  - Konishi T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Otol Rhinol Laryngol
JT  - The Annals of otology, rhinology, and laryngology
JID - 0407300
RN  - 0 (Chlorides)
RN  - PDC6A3C0OX (Glycerol)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Chlorides/*metabolism
MH  - Cochlear Microphonic Potentials/drug effects
MH  - Endolymph/*drug effects/metabolism
MH  - Glycerol/administration & dosage/*pharmacology
MH  - Guinea Pigs
MH  - Labyrinthine Fluids/*drug effects
MH  - *Osmolar Concentration
MH  - Perilymph/*drug effects/metabolism
MH  - Potassium/*metabolism
MH  - Time Factors
EDAT- 1987/07/01 00:00
MHDA- 1987/07/01 00:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 1987/07/01 00:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - 10.1177/000348948709600422 [doi]
PST - ppublish
SO  - Ann Otol Rhinol Laryngol. 1987 Jul-Aug;96(4):461-7. doi: 
      10.1177/000348948709600422.