PMID- 36194333
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230216
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 7
DP  - 2023 Feb
TI  - Association of exposure to multiple serum metals with the risk of chronic kidney 
      disease in the elderly: a population-based case-control study.
PG  - 17245-17256
LID - 10.1007/s11356-022-23303-2 [doi]
AB  - In the world, chronic kidney disease (CKD) has been recognized as one of the 
      critical public health problems, and the prevalence is higher in the elderly 
      people. However, there are few studies on the association between exposure to 
      multiple serum metal levels and CKD. A case-control study, we established, for 
      elderly people in Anhui Province, China, to explore the effects of different 
      metals and analyze the effect of mixed exposure on CKD. In this study, 287 cases 
      of CKD and 287 controls were selected in the elderly health physical examination 
      project in Tongling City, Anhui Province. Questionnaire survey, physical 
      examination, and blood collection were conducted. Graphite furnace atomic 
      absorption spectrometry (GFAAS) and inductively coupled plasma optical emission 
      spectrometry (ICP-OES) were used to measure the concentration of serum metals. 
      After selecting by least absolute shrinkage and selection operator (LASSO), 5 
      metals were brought into the multi-metal model. After adjusting all potential 
      covariates additionally, the concentrations of lead (Pb), cadmium (Cd), cobalt 
      (Co), and manganese (Mn) were significantly associated with CKD risk, whereas Pb, 
      Se, and Cd had significant non-linearity with CKD. Besides, patients with highest 
      quartiles of cobalt (Co), lead (Pb), and manganese (Mn) were 1.64, 1.39, and 0.64 
      times more possible to have CKD, respectively, as compared with the lowest 
      levels. In the Bayesian kernel machine regression (BKMR) model, cadmium (Cd) had 
      a combined effect with lead (Pb) possibly. This study suggested that the CKD risk 
      was associated with exposure of multiple metals in elderly people. The underlying 
      mechanisms of serum metals and CKD need more experimental and prospective studies 
      to elucidate.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Hu, Wenlei
AU  - Hu W
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - Li, Guoao
AU  - Li G
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - He, Jialiu
AU  - He J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - Zhao, Huanhuan
AU  - Zhao H
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - Zhang, Hanshuang
AU  - Zhang H
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - Lu, Huanhuan
AU  - Lu H
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - Liu, Jianjun
AU  - Liu J
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China.
FAU - Huang, Fen
AU  - Huang F
AUID- ORCID: 0000-0003-2127-3668
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, 
      China. fenh@ahmu.edu.cn.
LA  - eng
GR  - gxbjZD09/The Project for Top Disciplinary Talents of Majors in Universities of 
      Anhui Province/
PT  - Journal Article
DEP - 20221004
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Metals, Heavy)
RN  - 00BH33GNGH (Cadmium)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 2P299V784P (Lead)
RN  - 3G0H8C9362 (Cobalt)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Metals, Heavy/chemistry
MH  - Cadmium
MH  - Manganese
MH  - Prospective Studies
MH  - Bayes Theorem
MH  - Case-Control Studies
MH  - Lead
MH  - Cobalt
MH  - *Renal Insufficiency, Chronic/chemically induced/epidemiology
OTO - NOTNLM
OT  - Case-control study
OT  - Chronic kidney disease
OT  - Multiple metal exposure
OT  - Serum metals
OT  - The elderly
EDAT- 2022/10/05 06:00
MHDA- 2023/02/17 06:00
CRDT- 2022/10/04 11:15
PHST- 2022/06/08 00:00 [received]
PHST- 2022/09/23 00:00 [accepted]
PHST- 2022/10/05 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2022/10/04 11:15 [entrez]
AID - 10.1007/s11356-022-23303-2 [pii]
AID - 10.1007/s11356-022-23303-2 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Feb;30(7):17245-17256. doi: 
      10.1007/s11356-022-23303-2. Epub 2022 Oct 4.