PMID- 36194767
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20230406
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 48
IP  - 12
DP  - 2022 Dec 1
TI  - Rate and Characteristics of Incompletely Excised Cutaneous Squamous Cell 
      Carcinoma: A Dermatological Daily Practice Multicenter Prospective Cohort Study.
PG  - 1269-1273
LID - 10.1097/DSS.0000000000003606 [doi]
AB  - BACKGROUND: Incomplete excision of squamous cell carcinoma (cSCC) is associated 
      with an increased risk of recurrence, metastasis, and mortality. OBJECTIVE: To 
      determine the rate and characteristics of incompletely excised cSCC in a 
      dermatological daily practice setting. METHODS: Prospective study of all patients 
      who gave informed consent, with a cSCC treated with standard excision (SE) at 1 
      of 6 Departments of Dermatology in the Netherlands between 2015 and 2017. 
      Pathological reports were screened to detect all incompletely excised cSCCs. 
      RESULTS: A total of 592 patients with 679 cSCCs were included, whereby most cases 
      were low risk cSCC (89%). The rate of incompletely excised cSCC was 4% ( n = 26), 
      and the majority were high-risk cSCCs of which 24 invaded the deep excision 
      margin. CONCLUSION: This prospective study showed that in a dermatological 
      setting, the risk of an incompletely excised cSCC is low (4%) for a cohort that 
      was dominated by low-risk cSCCs. Most incompletely excised cSCCs were of high 
      risk, and incompleteness was almost always at the deep margins. These results 
      suggest that for high-risk cSCC, one should pay attention especially to the deep 
      margin when performing SE, and/or microscopic surgery should be considered.
CI  - Copyright (c) 2022 by the American Society for Dermatologic Surgery, Inc. Published 
      by Wolters Kluwer Health, Inc. All rights reserved.
FAU - van Lee, Charlotte B
AU  - van Lee CB
AD  - Department of Dermatology, Erasmus Medical Centre Cancer Institute, Rotterdam, 
      the Netherlands.
FAU - Kouloubis, Nina
AU  - Kouloubis N
AD  - Department of Dermatology, Maastricht University Medical Centre, Maastricht, the 
      Netherlands.
FAU - Wakkee, Marlies
AU  - Wakkee M
AD  - Department of Dermatology, Erasmus Medical Centre Cancer Institute, Rotterdam, 
      the Netherlands.
FAU - Kelleners-Smeets, Nicole W J
AU  - Kelleners-Smeets NWJ
AD  - Department of Dermatology, Maastricht University Medical Centre, Maastricht, the 
      Netherlands.
FAU - Nellen, Ruud G L
AU  - Nellen RGL
AD  - Departement of Dermatology, IJsselland Ziekenhuis, Capelle aan den IJssel, the 
      Netherlands.
FAU - van Rengen, Annik
AU  - van Rengen A
AD  - Department of Dermatology, Mohs Klinieken, Dordrecht, the Netherlands.
FAU - de Vijlder, Hanke C
AU  - de Vijlder HC
AD  - Department of Dermatology, Isala Ziekenhuis, Zwolle, the Netherlands.
FAU - Wijne, Leon C C
AU  - Wijne LCC
AD  - Department of Dermatology, Erasmus Medical Centre Cancer Institute, Rotterdam, 
      the Netherlands.
AD  - Department of Dermatology, Amphia Ziekenhuis, Breda, the Netherlands.
FAU - Nijsten, Tamar
AU  - Nijsten T
AD  - Department of Dermatology, Erasmus Medical Centre Cancer Institute, Rotterdam, 
      the Netherlands.
FAU - van den Bos, Renate R
AU  - van den Bos RR
AD  - Department of Dermatology, Erasmus Medical Centre Cancer Institute, Rotterdam, 
      the Netherlands.
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Multicenter Study
DEP - 20221004
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
SB  - IM
CON - Acta Derm Venereol. 2020 Mar 18;100(6):adv00084. PMID: 32128598
MH  - Humans
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Prospective Studies
MH  - *Skin Neoplasms/pathology
MH  - Margins of Excision
MH  - Cohort Studies
EDAT- 2022/10/05 06:00
MHDA- 2022/12/03 06:00
CRDT- 2022/10/04 15:03
PHST- 2022/10/05 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/10/04 15:03 [entrez]
AID - 00042728-202212000-00001 [pii]
AID - 10.1097/DSS.0000000000003606 [doi]
PST - ppublish
SO  - Dermatol Surg. 2022 Dec 1;48(12):1269-1273. doi: 10.1097/DSS.0000000000003606. 
      Epub 2022 Oct 4.