PMID- 36195907
OWN - NLM
STAT- MEDLINE
DCOM- 20221006
LR  - 20221009
IS  - 2662-7671 (Electronic)
IS  - 2662-7671 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Oct 4
TI  - Anti-inflammatory, cytotoxicity and antilipidemic properties: novel bioactivities 
      of true cinnamon (Cinnamomum zeylanicum Blume) leaf.
PG  - 259
LID - 10.1186/s12906-022-03728-5 [doi]
LID - 259
AB  - BACKGROUND: The leaf of Ceylon cinnamon (true cinnamon) is traditionally claimed 
      for a variety of health benefits. However, reported scientific information is 
      scanty and needs urgent attention for value addition. METHODS: Ethanolic (95%) 
      and Dichloromethane:Methanol (DM, 1:1 v/v) leaf extracts of Ceylon cinnamon were 
      evaluated for a range of medically important bioactivities namely 
      anti-inflammatory [nitric oxide scavenging activity (NOSA), superoxide scavenging 
      activity (SCA), COX1 and COX2 inhibition], growth inhibition & cytotoxicity 
      against MCF7, HePG2 and AN3CA carcinoma cell lines, glutathionase-S-transferase 
      (GST) inhibition and antilipidemic (anti-HMG-CoA reductase, anti-lipase, 
      anti-cholesterol esterase, and cholesterol micellization inhibition) properties 
      in vitro (n = 3). Further, a range of bioactive compounds in both leaf extracts 
      was also quantified (n = 3). RESULTS: Both leaf extracts had all the investigated 
      bioactive compounds and possessed moderately potent bioactivities compared to the 
      reference drugs used in the study. Ethanolic leaf extract (ELE) exhibited the 
      highest activities (IC(50:) mug/mL) for NOSA (40.26 +/- 0.52), SCA (696.24 +/- 40.02), 
      cholesterol esterase inhibition (110.19 +/- 1.55), cholesterol micellization 
      inhibition (616.69 +/- 7.09), GST inhibition (403.78 +/- 2.70) and growth inhibition 
      (GI(50): 144.84 +/- 1.59-269.00 +/- 0.51) & cytotoxicity (LC(50): 
      355.44 +/- 9.38-717.71 +/- 23.69) against studied cancer cell lines. In contrast, 
      COX1 & COX2 (IC(50:) 6.62 +/- 0.85 and 44.91 +/- 3.06 mug/mL) and HMG-CoA reductase & 
      lipase inhibitory activities (36.72 +/- 4.74 and 19.71 +/- 0.97% inhibition at 200 
      and 600 mug/mL) were highest in DM extract. ELE also showed the highest quantities 
      (0.81 +/- 0.06-104.38 +/- 1.79) of tested compounds (mg/g extract) where eugenol was 
      the highest and gallic acid was the lowest among quantified. CONCLUSION: Both 
      leaf extracts of Ceylon cinnamon had all the tested bioactive compounds and 
      possess all the investigated bioactivities. This is the 1st study to report all 
      the investigated bioactivities of the leaf of Ceylon Cinnamon.
CI  - (c) 2022. The Author(s).
FAU - Abeysekera, Walimuni Prabhashini Kaushalya Mendis
AU  - Abeysekera WPKM
AD  - Department of Biosystems Technology, Faculty of Technology, University of Sri 
      Jayewardenepura, Pitipana, Homagama, Sri Lanka. kaushalyaabey@sjp.ac.lk.
FAU - Premakumara, Galbada Arachchige Sirimal
AU  - Premakumara GAS
AD  - Department of Basic Science and Social Science, Faculty of Nursing, University of 
      Colombo, Colombo, Sri Lanka.
FAU - Ratnasooriya, Wanigasekera Daya
AU  - Ratnasooriya WD
AD  - Department of Zoology and Environmental Sciences, Faculty of Science, University 
      of Colombo, Colombo, Sri Lanka.
FAU - Abeysekera, Walimuni Kanchana Subhashini Mendis
AU  - Abeysekera WKSM
AD  - Department of Agricultural Technology, Faculty of Technology, University of 
      Colombo, Colombo, Sri Lanka.
LA  - eng
PT  - Journal Article
DEP - 20221004
PL  - England
TA  - BMC Complement Med Ther
JT  - BMC complementary medicine and therapies
JID - 101761232
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Extracts)
RN  - 11062-77-4 (Superoxides)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3T8H1794QW (Eugenol)
RN  - 588X2YUY0A (Methylene Chloride)
RN  - 632XD903SP (Gallic Acid)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 2.- (Transferases)
RN  - EC 3.1.- (Esterases)
RN  - SAA04E81UX (Coenzyme A)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology
MH  - *Cinnamomum zeylanicum
MH  - Coenzyme A
MH  - Cyclooxygenase 2
MH  - Esterases
MH  - Eugenol
MH  - Gallic Acid
MH  - Methanol
MH  - Methylene Chloride
MH  - Nitric Oxide
MH  - *Oils, Volatile
MH  - Oxidoreductases
MH  - Plant Extracts/metabolism/pharmacology
MH  - Superoxides
MH  - Transferases
PMC - PMC9531470
OTO - NOTNLM
OT  - Anti-inflammatory
OT  - Antilipidemic
OT  - Ceylon cinnamon
OT  - Growth inhibition & cytotoxicity
OT  - Leaf extracts
COIS- The authors declare that they have no competing interest.
EDAT- 2022/10/05 06:00
MHDA- 2022/10/07 06:00
PMCR- 2022/10/04
CRDT- 2022/10/04 23:37
PHST- 2022/06/11 00:00 [received]
PHST- 2022/09/12 00:00 [accepted]
PHST- 2022/10/04 23:37 [entrez]
PHST- 2022/10/05 06:00 [pubmed]
PHST- 2022/10/07 06:00 [medline]
PHST- 2022/10/04 00:00 [pmc-release]
AID - 10.1186/s12906-022-03728-5 [pii]
AID - 3728 [pii]
AID - 10.1186/s12906-022-03728-5 [doi]
PST - epublish
SO  - BMC Complement Med Ther. 2022 Oct 4;22(1):259. doi: 10.1186/s12906-022-03728-5.