PMID- 36196614
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20240313
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 76
IP  - 2
DP  - 2023 Jan 13
TI  - Booster Vaccination Against SARS-CoV-2 Induces Potent Immune Responses in People 
      With Human Immunodeficiency Virus.
PG  - 201-209
LID - 10.1093/cid/ciac796 [doi]
AB  - BACKGROUND: People with human immunodeficiency virus (HIV) on antiretroviral 
      therapy (ART) with good CD4 T-cell counts make effective immune responses 
      following vaccination against severe acute respiratory syndrome coronavirus 2 
      (SARS-CoV-2). There are few data on longer term responses and the impact of a 
      booster dose. METHODS: Adults with HIV were enrolled into a single arm open label 
      study. Two doses of ChAdOx1 nCoV-19 were followed 12 months later by a third 
      heterologous vaccine dose. Participants had undetectable viraemia on ART and CD4 
      counts >350 cells/microL. Immune responses to the ancestral strain and variants of 
      concern were measured by anti-spike immunoglobulin G (IgG) enzyme-linked 
      immunosorbent assay (ELISA), MesoScale Discovery (MSD) anti-spike platform, ACE-2 
      inhibition, activation induced marker (AIM) assay, and T-cell proliferation. 
      FINDINGS: In total, 54 participants received 2 doses of ChAdOx1 nCoV-19. 43 
      received a third dose (42 with BNT162b2; 1 with mRNA-1273) 1 year after the first 
      dose. After the third dose, total anti-SARS-CoV-2 spike IgG titers (MSD), ACE-2 
      inhibition, and IgG ELISA results were significantly higher compared to Day 182 
      titers (P < .0001 for all 3). SARS-CoV-2 specific CD4+ T-cell responses measured 
      by AIM against SARS-CoV-2 S1 and S2 peptide pools were significantly increased 
      after a third vaccine compared to 6 months after a first dose, with significant 
      increases in proliferative CD4+ and CD8+ T-cell responses to SARS-CoV-2 S1 and S2 
      after boosting. Responses to Alpha, Beta, Gamma, and Delta variants were boosted, 
      although to a lesser extent for Omicron. CONCLUSIONS: In PWH receiving a third 
      vaccine dose, there were significant increases in B- and T-cell immunity, 
      including to known variants of concern (VOCs).
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America.
FAU - Fidler, Sarah
AU  - Fidler S
AD  - Department of Infectious Disease, Faculty of Medicine, Imperial College London, 
      London, United Kingdom.
AD  - Department of HIV Medicine, St Mary's Hospital, Imperial College Healthcare 
      National Health Service (NHS) Trust, London, United Kingdom.
AD  - National Institute for Health and Care Research (NIHR) Imperial Clinical Research 
      Facility and NIHR Imperial Biomedical Research Centre, London, United Kingdom.
FAU - Fox, Julie
AU  - Fox J
AD  - NIHR Guy's and St Thomas' Biomedical Research Centre, London, United Kingdom.
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Tipoe, Timothy
AU  - Tipoe T
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Longet, Stephanie
AU  - Longet S
AD  - Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University 
      of Oxford, Oxford, United Kingdom.
FAU - Tipton, Tom
AU  - Tipton T
AD  - Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University 
      of Oxford, Oxford, United Kingdom.
FAU - Abeywickrema, Movin
AU  - Abeywickrema M
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Adele, Sandra
AU  - Adele S
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Alagaratnam, Jasmini
AU  - Alagaratnam J
AD  - Department of Infectious Disease, Faculty of Medicine, Imperial College London, 
      London, United Kingdom.
AD  - Department of HIV Medicine, St Mary's Hospital, Imperial College Healthcare 
      National Health Service (NHS) Trust, London, United Kingdom.
FAU - Ali, Mohammad
AU  - Ali M
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Aley, Parvinder K
AU  - Aley PK
AD  - Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, 
      United Kingdom.
FAU - Aslam, Suhail
AU  - Aslam S
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Balasubramanian, Anbhu
AU  - Balasubramanian A
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Bara, Anna
AU  - Bara A
AD  - National Institute for Health and Care Research (NIHR) Imperial Clinical Research 
      Facility and NIHR Imperial Biomedical Research Centre, London, United Kingdom.
FAU - Bawa, Tanveer
AU  - Bawa T
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Brown, Anthony
AU  - Brown A
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Brown, Helen
AU  - Brown H
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Cappuccini, Federica
AU  - Cappuccini F
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Davies, Sophie
AU  - Davies S
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Fowler, Jamie
AU  - Fowler J
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Godfrey, Leila
AU  - Godfrey L
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Goodman, Anna L
AU  - Goodman AL
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
AD  - Medical Research Council Clinical Trials Unit, University College London, London, 
      United Kingdom.
FAU - Hilario, Kathrine
AU  - Hilario K
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Hackstein, Carl-Philipp
AU  - Hackstein CP
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Mathew, Moncy
AU  - Mathew M
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Mujadidi, Yama F
AU  - Mujadidi YF
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Packham, Alice
AU  - Packham A
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Petersen, Claire
AU  - Petersen C
AD  - Department of Infectious Disease, Faculty of Medicine, Imperial College London, 
      London, United Kingdom.
AD  - Department of HIV Medicine, St Mary's Hospital, Imperial College Healthcare 
      National Health Service (NHS) Trust, London, United Kingdom.
FAU - Plested, Emma
AU  - Plested E
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Pollock, Katrina M
AU  - Pollock KM
AD  - National Institute for Health and Care Research (NIHR) Imperial Clinical Research 
      Facility and NIHR Imperial Biomedical Research Centre, London, United Kingdom.
FAU - Ramasamy, Maheshi N
AU  - Ramasamy MN
AD  - Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, 
      United Kingdom.
AD  - Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
FAU - Robinson, Hannah
AU  - Robinson H
AD  - Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, 
      United Kingdom.
FAU - Robinson, Nicola
AU  - Robinson N
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
AD  - NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
FAU - Rongkard, Patpong
AU  - Rongkard P
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Sanders, Helen
AU  - Sanders H
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Serafimova, Teona
AU  - Serafimova T
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Spence, Niamh
AU  - Spence N
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Waters, Anele
AU  - Waters A
AD  - Department of Infection, Harrison Wing and NIHR Clinical Research Facility, Guys 
      and St Thomas' NHS Trust, London, United Kingdom.
FAU - Woods, Danielle
AU  - Woods D
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Zacharopoulou, Panagiota
AU  - Zacharopoulou P
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Barnes, Eleanor
AU  - Barnes E
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
AD  - Department of HIV Medicine, St Mary's Hospital, Imperial College Healthcare 
      National Health Service (NHS) Trust, London, United Kingdom.
AD  - Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
AD  - NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
FAU - Dunachie, Susanna
AU  - Dunachie S
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
AD  - Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
AD  - Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, 
      University of Oxford, Oxford, United Kingdom.
AD  - Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, 
      Thailand.
FAU - Goulder, Philip
AU  - Goulder P
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
AD  - Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
AD  - Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
FAU - Klenerman, Paul
AU  - Klenerman P
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
AD  - Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
AD  - NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
FAU - Winston, Alan
AU  - Winston A
AD  - Department of Infectious Disease, Faculty of Medicine, Imperial College London, 
      London, United Kingdom.
AD  - Department of HIV Medicine, St Mary's Hospital, Imperial College Healthcare 
      National Health Service (NHS) Trust, London, United Kingdom.
FAU - Hill, Adrian V S
AU  - Hill AVS
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Gilbert, Sarah C
AU  - Gilbert SC
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
FAU - Carroll, Miles
AU  - Carroll M
AD  - Nuffield Department of Medicine, Wellcome Centre for Human Genetics, University 
      of Oxford, Oxford, United Kingdom.
AD  - Public Health England, Porton Down, Salisbury, United Kingdom.
FAU - Pollard, Andrew J
AU  - Pollard AJ
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
AD  - NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
FAU - Lambe, Teresa
AU  - Lambe T
AD  - Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, 
      United Kingdom.
AD  - Nuffield Department of Medicine, The Jenner Institute, University of Oxford, 
      Oxford, United Kingdom.
AD  - Chinese Academy of Medical Sciences Oxford Institute, Oxford, United Kingdom.
FAU - Ogbe, Ane
AU  - Ogbe A
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
FAU - Frater, John
AU  - Frater J
AUID- ORCID: 0000-0001-7163-7277
AD  - Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen 
      Research, University of Oxford, Oxford, United Kingdom.
AD  - Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
AD  - NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
LA  - eng
GR  - 403193363/WT_/Wellcome Trust/United Kingdom
GR  - MC_UU_00004/04/MRC_/Medical Research Council/United Kingdom
GR  - MR/L00528X/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/W024977/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/X009297/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/L006588/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/W02067X/1/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - B5S3K2V0G8 (ChAdOx1 nCoV-19)
RN  - 0 (BNT162 Vaccine)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Antibodies, Viral)
RN  - SARS-CoV-2 variants
SB  - IM
MH  - Adult
MH  - Humans
MH  - HIV
MH  - ChAdOx1 nCoV-19
MH  - BNT162 Vaccine
MH  - SARS-CoV-2
MH  - *COVID-19/prevention & control
MH  - Lymphocyte Activation
MH  - Vaccination
MH  - *HIV Infections/drug therapy
MH  - Immunoglobulin G
MH  - Antibodies, Viral
PMC - PMC9619587
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - T-cell responses
OT  - antibody responses
OT  - people with HIV
OT  - vaccination
EDAT- 2022/10/06 06:00
MHDA- 2023/01/18 06:00
PMCR- 2022/10/05
CRDT- 2022/10/05 03:53
PHST- 2022/05/18 00:00 [received]
PHST- 2022/10/06 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/10/05 03:53 [entrez]
PHST- 2022/10/05 00:00 [pmc-release]
AID - 6748267 [pii]
AID - ciac796 [pii]
AID - 10.1093/cid/ciac796 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2023 Jan 13;76(2):201-209. doi: 10.1093/cid/ciac796.