PMID- 36196628
OWN - NLM
STAT- MEDLINE
DCOM- 20230518
LR  - 20230622
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 57
IP  - 6
DP  - 2023 Jun
TI  - Impact of Metabolic Syndrome on Left Ventricular Deformation and Myocardial 
      Energetic Efficiency Compared Between Women and Men: An MRI Study.
PG  - 1743-1751
LID - 10.1002/jmri.28455 [doi]
AB  - BACKGROUND: Metabolic and hemodynamic alterations in metabolic syndrome (MetS) 
      can cause a reduced myocardial energetic efficiency (MEE). Indexed MEE (MEEi), as 
      a simple estimate of MEE, is emerging as a novel and useful imaging parameter. 
      PURPOSE: To investigate the impact of MetS on MEE and systolic myocardial strain 
      and to assess any sex difference. STUDY TYPE: Retrospective. POPULATION: A total 
      of 161 patients with MetS (female: n = 82, 52.2 +/- 11.7 years; male: n = 79, 
      51.8 +/- 10.6 years) and 77 healthy subjects (female: n = 46, 52.7 +/- 8.2 years; 
      male: n = 31, 54.1 +/- 11.2 years). Patients with left ventricular (LV) ejection 
      fraction <50% were excluded. FIELD STRENGTH/SEQUENCE: A 3.0 T; balanced 
      steady-state free precession sequence. ASSESSMENT: LV volumes and mass (LVM) and 
      global longitudinal strain (GLS) were obtained by MRI. Stroke volume (SV) divided 
      by HR was used as a surrogate measure of MEE and normalized to LVM (MEEi). 
      STATISTICAL TESTS: Student's t-test or Mann-Whitney U-test; Multivariable linear 
      regression (coefficient of determination, R(2) ). P < 0.05 was considered 
      statistically significant. RESULTS: For both males and females, MEEi and GLS were 
      lower in MetS patients than in the normal controls. Among MetS patients, men had 
      significantly higher LVM (59.7 +/- 13.4 g/m(2) vs. 48.8 +/- 11.3 g/m(2) ) and 
      significantly lower MEEi (0.68 +/- 0.23 mL/g/s vs. 0.84 +/- 0.23 mL/g/s) and GLS 
      (-11.7% +/- 2.8% vs. -13.9% +/- 2.7%) than women. After adjustment for clinical 
      variables, male gender (beta = -0.291) was found to be inversely correlated with 
      MEEi. Multivariable analysis showed that MEEi (beta = 0.454) were independently 
      associated with GLS (adjusted R(2)  = 0.454) after adjustment for clinical and 
      other MRI parameters. DATA CONCLUSION: MEEi was significantly impaired in MetS 
      without overt systolic dysfunction. There was a sex difference regarding the 
      cardiac alterations in MetS, with men having significantly lower MEEi and GLS and 
      significantly higher LVM than women. Further, MEEi was independently associated 
      with GLS. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 3.
CI  - (c) 2022 International Society for Magnetic Resonance in Medicine.
FAU - Huang, Shan
AU  - Huang S
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Shi, Ke
AU  - Shi K
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Wang, Jin
AU  - Wang J
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Jiang, Li
AU  - Jiang L
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Gao, Yue
AU  - Gao Y
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Yan, Wei-Feng
AU  - Yan WF
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
AUID- ORCID: 0000-0001-9341-7697
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221005
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - *Metabolic Syndrome/complications/diagnostic imaging
MH  - Retrospective Studies
MH  - *Ventricular Dysfunction, Left/diagnostic imaging
MH  - Ventricular Function, Left
MH  - Stroke Volume
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - metabolic syndrome
OT  - myocardial energetic efficiency
OT  - myocardial strain
OT  - sex difference
EDAT- 2022/10/06 06:00
MHDA- 2023/05/18 06:42
CRDT- 2022/10/05 04:13
PHST- 2022/09/15 00:00 [revised]
PHST- 2022/08/05 00:00 [received]
PHST- 2022/09/16 00:00 [accepted]
PHST- 2023/05/18 06:42 [medline]
PHST- 2022/10/06 06:00 [pubmed]
PHST- 2022/10/05 04:13 [entrez]
AID - 10.1002/jmri.28455 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2023 Jun;57(6):1743-1751. doi: 10.1002/jmri.28455. Epub 
      2022 Oct 5.