PMID- 36197746
OWN - NLM
STAT- MEDLINE
DCOM- 20231108
LR  - 20231108
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 33
IP  - 6
DP  - 2023 Nov 1
TI  - Chemoprophylaxis against Pneumocystis jirovecii pneumonia in Japanese patients 
      with ANCA-associated vasculitis: An observational study.
PG  - 1137-1144
LID - 10.1093/mr/roac124 [doi]
AB  - OBJECTIVES: This study investigated the current practice of prophylactic 
      treatment against Pneumocystis jirovecii pneumonia (PCP) and its effectiveness in 
      patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). 
      METHODS: This study included 319 patients registered from 53 institutions in 
      Japan and newly diagnosed with AAV. During the 2-year observation period, we 
      examined the frequency of usage, effectiveness and safety of prophylactic drugs 
      against PCP. RESULTS: Most patients received prophylactic drugs against PCP with 
      the initiation of immunosuppressive agents, and >50% of them remained on 
      chemoprophylaxis against PCP at 2 years after. The initial daily dose of oral 
      prednisolone and the proportion of cyclophosphamide administration were higher in 
      patients who received chemoprophylaxis against PCP than in those who did not. PCP 
      occurred in nine patients (3%) and resulted in the death of four. The incidence 
      rate of PCP in patients who received chemoprophylaxis was 1.13/100 patient-years 
      (95% confidence interval, 0.38-2.68) and that in those who did not was 2.74 
      (1.04-6.02). The incidence rate ratio was 0.41 (0.11-1.53). CONCLUSIONS: The 
      markedly low incidence of PCP may be attributed to the continuous 
      chemoprophylaxis against PCP received by >50% of Japanese patients with AAV, 
      although the effectiveness of chemoprophylaxis against PCP was not statistically 
      confirmed.
CI  - (c) Japan College of Rheumatology 2022. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Nakaya, Izaya
AU  - Nakaya I
AD  - Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, 
      Morioka, Japan.
FAU - Sada, Ken-Ei
AU  - Sada KE
AUID- ORCID: 0000-0003-1020-0818
AD  - Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama 
      University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 
      Okayama, Japan.
AD  - Department of Clinical Epidemiology, Kochi Medical School, Kochi University, 
      Nankoku, Japan.
FAU - Harigai, Masayoshi
AU  - Harigai M
AUID- ORCID: 0000-0002-6418-2603
AD  - Department of Rheumatology, Tokyo Women's Medical University School of Medicine, 
      Tokyo, Japan.
FAU - Soma, Jun
AU  - Soma J
AD  - Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, 
      Morioka, Japan.
FAU - Amano, Koichi
AU  - Amano K
AD  - Department of Rheumatology and Clinical Immunology, Saitama Medical Centre, 
      Saitama Medical University, Saitama, Japan.
FAU - Dobashi, Hiroaki
AU  - Dobashi H
AD  - Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine, Kagawa University, Miki, Japan.
FAU - Atsumi, Tatsuya
AU  - Atsumi T
AD  - Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, 
      Hokkaido University, Sapporo, Japan.
FAU - Yuzawa, Yukio
AU  - Yuzawa Y
AD  - Department of Nephrology, Fujita Health University School of Medicine, Toyoake, 
      Japan.
FAU - Fujimoto, Shouichi
AU  - Fujimoto S
AD  - Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, 
      Miyazaki University, Miyazaki, Japan.
FAU - Sugihara, Takahiko
AU  - Sugihara T
AD  - Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
AD  - Division of Rheumatology & Allergology, Department of Internal Medicine, St. 
      Marianna University School of Medicine, Kawasaki, Japan.
FAU - Takasaki, Yoshinari
AU  - Takasaki Y
AD  - Department of Internal Medicine and Rheumatology, Juntendo University School of 
      Medicine, Tokyo, Japan.
FAU - Arimura, Yoshihiro
AU  - Arimura Y
AD  - Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin 
      University School of Medicine, Tokyo, Japan.
AD  - Department of Internal Medicine, Kichijoji Asahi Hospital, Tokyo, Japan.
FAU - Makino, Hirofumi
AU  - Makino H
AD  - The president, Okayama University, Okayama, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Humans
MH  - *Pneumonia, Pneumocystis/etiology
MH  - East Asian People
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy
MH  - Immunosuppressive Agents/therapeutic use
MH  - Chemoprevention/adverse effects
MH  - *Pneumocystis carinii
OTO - NOTNLM
OT  - Anti-neutrophil cytoplasm antibody
OT  - granulomatosis with polyangiitis
OT  - infection
OT  - microscopic polyangiitis
OT  - systemic vasculitis
EDAT- 2022/10/06 06:00
MHDA- 2023/11/08 06:42
CRDT- 2022/10/05 12:32
PHST- 2022/08/22 00:00 [received]
PHST- 2022/09/29 00:00 [accepted]
PHST- 2023/11/08 06:42 [medline]
PHST- 2022/10/06 06:00 [pubmed]
PHST- 2022/10/05 12:32 [entrez]
AID - 6748927 [pii]
AID - 10.1093/mr/roac124 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2023 Nov 1;33(6):1137-1144. doi: 10.1093/mr/roac124.