PMID- 36199035
OWN - NLM
STAT- MEDLINE
DCOM- 20221007
LR  - 20221015
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Oct 5
TI  - Sysmex UN2000 detection of protein/creatinine ratio and of renal tubular 
      epithelial cells can be used for screening lupus nephritis.
PG  - 328
LID - 10.1186/s12882-022-02953-x [doi]
LID - 328
AB  - OBJECTIVES: This study is aimed to evaluate if automated urine sediment analysis 
      UN2000 can be used to screen lupus nephritis. METHODS: UN2000 was used to examine 
      160 urine samples from patients with systemic lupus erythematosus and 124 urine 
      samples from Lupus nephritis. The result of protein/creatinine ratio(P/C) and 
      renal tubular epithelial cells (RTEC) were evaluated. With biochemical analysis 
      and microscopic examination as the gold standard, the Kappa consistency test was 
      used to analyze the accuracy of P/C and RTEC. Analysis was to evaluate the 
      accuracy of P/C single item or RTEC single item and both screening 
      lupusnephritis. RESULTS: The consistency of P/C and the gold standard, and that 
      of RTEC and the gold standard are respectively strong and good (0.858 vs. 0.673). 
      The specificity, positive predictive value, and coincidence were the highest when 
      P/C >/= 2 + was set as the only screening standard for lupus nephritis. When the 
      standard was selected between P/C >/= 2 + or RTEC > 2.8 cells/microl, the sensitivity 
      and negative predictive value were the highest. CONCLUSION: UN 2000 can be used 
      to screen lupus nephritis by detecting P/C and RTEC.
CI  - (c) 2022. The Author(s).
FAU - Chen, Yabin
AU  - Chen Y
AD  - Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Zhao, Yuan
AU  - Zhao Y
AD  - Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military 
      Medical University (Air Force Medical University), 127 Changle West Road, 710032, 
      Xi'an, Shaanxi, China.
FAU - Zhang, Zhishan
AU  - Zhang Z
AD  - Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Cheng, Xiang
AU  - Cheng X
AD  - Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military 
      Medical University (Air Force Medical University), 127 Changle West Road, 710032, 
      Xi'an, Shaanxi, China.
FAU - Lin, Jie
AU  - Lin J
AD  - Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military 
      Medical University (Air Force Medical University), 127 Changle West Road, 710032, 
      Xi'an, Shaanxi, China.
FAU - Li, Jiaming
AU  - Li J
AD  - Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Wu, Yibo
AU  - Wu Y
AD  - Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Lin, Zhen Zhong
AU  - Lin ZZ
AD  - Clinical Laboratory, Quanzhou First Hospital Affiliated to Fujian Medical 
      University, Quanzhou, China.
FAU - Jing, Jing
AU  - Jing J
AD  - Department of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military 
      Medical University (Air Force Medical University), 127 Changle West Road, 710032, 
      Xi'an, Shaanxi, China. sevencee@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20221005
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Creatinine/urine
MH  - Epithelial Cells
MH  - Humans
MH  - *Lupus Erythematosus, Systemic/complications
MH  - *Lupus Nephritis/diagnosis/urine
MH  - Urinalysis
PMC - PMC9536011
OTO - NOTNLM
OT  - Lupus nephritis
OT  - P/C
OT  - RTEC
OT  - Systemic lupus erythematosus
OT  - UN2000
COIS- No conflict of interest exists in the submission of this manuscript, and this 
      manuscript is approved by all authors for publication.
EDAT- 2022/10/06 06:00
MHDA- 2022/10/12 06:00
PMCR- 2022/10/05
CRDT- 2022/10/05 23:37
PHST- 2022/06/07 00:00 [received]
PHST- 2022/09/21 00:00 [accepted]
PHST- 2022/10/05 23:37 [entrez]
PHST- 2022/10/06 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/10/05 00:00 [pmc-release]
AID - 10.1186/s12882-022-02953-x [pii]
AID - 2953 [pii]
AID - 10.1186/s12882-022-02953-x [doi]
PST - epublish
SO  - BMC Nephrol. 2022 Oct 5;23(1):328. doi: 10.1186/s12882-022-02953-x.