PMID- 36199220
OWN - NLM
STAT- MEDLINE
DCOM- 20221007
LR  - 20221019
IS  - 2192-6506 (Electronic)
IS  - 2192-6506 (Linking)
VI  - 87
IP  - 10
DP  - 2022 Oct
TI  - Facile Synthesis of Triazoles using Electrospray-Deposited Copper Nanomaterials 
      to Catalyze Azide-Alkyne Cycloaddition (AAC) Click Reactions.
PG  - e202200252
LID - 10.1002/cplu.202200252 [doi]
AB  - Electrospray deposition of copper salt-containing microdroplets onto the liquid 
      surface of an electrically grounded reaction mixture leads to the formation of Cu 
      nanoclusters, which then catalyze the azide-alkyne cycloaddition (AAC) reaction 
      to form triazoles. This method of in situ nanocatalyst preparation provided 17 
      times higher catalytic activity compared to that in the conventional catalytic 
      reaction. The gentle landing of the Cu-containing droplets onto the liquid 
      surface forms a thin film of catalyst which promotes the heterogeneous AAC 
      reaction while showing diffusion-controlled kinetics. UV-vis spectral 
      characterization confirms that the catalyst is comprised of Cu nanoclusters. This 
      unique catalytic strategy was validated using several substrates and the 
      corresponding products were confirmed by tandem mass spectrometry (MS/MS) 
      analysis.
CI  - (c) 2022 The Authors. ChemPlusChem published by Wiley-VCH GmbH.
FAU - Ghosh, Jyotirmoy
AU  - Ghosh J
AUID- ORCID: 0000-0002-3592-4903
AD  - Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 
      47907, USA.
FAU - Cooks, R Graham
AU  - Cooks RG
AUID- ORCID: 0000-0002-9581-9603
AD  - Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 
      47907, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - Chempluschem
JT  - ChemPlusChem
JID - 101580948
RN  - 0 (Alkynes)
RN  - 0 (Azides)
RN  - 0 (Triazoles)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Alkynes/chemistry
MH  - *Azides/chemistry
MH  - Click Chemistry
MH  - Copper/chemistry
MH  - Cycloaddition Reaction
MH  - *Nanostructures
MH  - Tandem Mass Spectrometry
MH  - Triazoles/chemistry
OTO - NOTNLM
OT  - click reaction
OT  - electrospray deposition
OT  - nanostructures
OT  - tandem mass spectrometry
OT  - triazoles
EDAT- 2022/10/07 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/10/06 01:03
PHST- 2022/09/09 00:00 [revised]
PHST- 2022/07/27 00:00 [received]
PHST- 2022/10/07 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/10/06 01:03 [entrez]
AID - 10.1002/cplu.202200252 [doi]
PST - ppublish
SO  - Chempluschem. 2022 Oct;87(10):e202200252. doi: 10.1002/cplu.202200252.