PMID- 36200314
OWN - NLM
STAT- MEDLINE
DCOM- 20230104
LR  - 20230131
IS  - 1463-1326 (Electronic)
IS  - 1462-8902 (Linking)
VI  - 25
IP  - 2
DP  - 2023 Feb
TI  - The impact of family history of type 2 diabetes on clinical heterogeneity in 
      idiopathic type 1 diabetes.
PG  - 417-425
LID - 10.1111/dom.14884 [doi]
AB  - AIM: To investigate the impact of family history of type 2 diabetes (T2D) on the 
      clinical phenotypes of patients with idiopathic type 1 diabetes (T1D). METHODS: 
      In clinically diagnosed T1D cases, a total of 335 idopathic T1D patients were 
      included in the study, after excluding autoimmune T1D using islet autoantibody 
      testing and monogenic diabetes using a custom monogenic diabetes gene panel 
      obtained from clinically diagnosed T1D cases. A semi-structured questionnaire was 
      used to collect information on the presence of T2D in first-degree relatives. The 
      demographic and metabolic markers of idiopathic T1D patients were analysed. 
      Subgroup analysis was performed to investigate potential interactions between T2D 
      family history and human leukocyte antigen (HLA) genotypes. RESULTS: A total of 
      18.2% of individuals with idiopathic T1D had a T2D family history, and these 
      individuals were more likely to have features associated with T2D, such as older 
      age of onset, higher body mass index at diagnosis, lower insulin dosage and 
      better beta-cell function, as indicated by higher levels of fasting C-peptide and 
      2-hour postprandial C-peptide (all P < 0.05). Additionally, regardless of HLA 
      susceptible genotypes, the impact of family history of T2D was consistently 
      observed in idiopathic T1D patients. Multivariable analyses showed that T2D 
      family history was negatively correlated with the risk of beta-cell function 
      failure in idiopathic T1D patients (P < 0.05). CONCLUSIONS: Family history of T2D 
      may be implicated in the heterogeneity of idiopathic T1D patients.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Chen, Yan
AU  - Chen Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
FAU - Wang, Qianrong
AU  - Wang Q
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
FAU - Xie, Zhiguo
AU  - Xie Z
AUID- ORCID: 0000-0001-5037-3807
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
FAU - Huang, Gan
AU  - Huang G
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
FAU - Fan, Li
AU  - Fan L
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
FAU - Li, Xia
AU  - Li X
AUID- ORCID: 0000-0001-8665-7983
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
FAU - Zhou, Zhiguang
AU  - Zhou Z
AUID- ORCID: 0000-0002-0374-1838
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221102
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (C-Peptide)
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 1/complications
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics/complications
MH  - C-Peptide
MH  - Insulin/genetics
MH  - Genotype
OTO - NOTNLM
OT  - family history
OT  - heterogeneity
OT  - human leukocyte antigen
OT  - idiopathic type 1 diabetes
OT  - type 2 diabetes
EDAT- 2022/10/07 06:00
MHDA- 2023/01/05 06:00
CRDT- 2022/10/06 03:42
PHST- 2022/09/28 00:00 [revised]
PHST- 2022/08/09 00:00 [received]
PHST- 2022/10/03 00:00 [accepted]
PHST- 2022/10/07 06:00 [pubmed]
PHST- 2023/01/05 06:00 [medline]
PHST- 2022/10/06 03:42 [entrez]
AID - 10.1111/dom.14884 [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2023 Feb;25(2):417-425. doi: 10.1111/dom.14884. Epub 2022 
      Nov 2.