PMID- 36200955
OWN - NLM
STAT- MEDLINE
DCOM- 20230420
LR  - 20230420
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 41
IP  - 4
DP  - 2023 Apr
TI  - Interstitial lung disease in microscopic polyangiitis and granulomatosis with 
      polyangiitis: demographic, clinical, serological and radiological features of an 
      Italian cohort from the Italian Society for Rheumatology.
PG  - 821-828
LID - 10.55563/clinexprheumatol/xu4hmh [doi]
AB  - OBJECTIVES: Interstitial lung disease (ILD) has been described as a possible 
      pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated 
      vasculitides (AAV), mainly granulomatosis with polyangiitis (GPA) and microscopic 
      polyangiitis (MPA). Aim of this cross-sectional Italian national study was to 
      describe demographic, clinical and serological profile of ILD related to MPA and 
      GPA and investigate possible correlations between radiologic patterns of ILD and 
      vasculitis features. METHODS: We enrolled 95 consecutive patients with AAV-ILD, 
      56 affected by MPA (58.9%) and 39 by GPA (41.1%). RESULTS: NSIP was the most 
      frequently detected ILD pattern, observed in c-ANCA patients in 60.9% of cases, 
      followed by UIP pattern mainly observed in p-ANCA patients (47.7%, p=0.03). ILD 
      represented the first clinical manifestation, preceding vasculitis diagnosis in 
      22.1% of cases and, globally, ILD was already detectable at AAV diagnosis in 
      66.3% of patients. The diagnosis of ILD preceded that of AAV in 85.7% of p-ANCA 
      positive-patients, while only one patient with c-ANCA developed ILD before AAV 
      (p= 0.039). Multivariate analysis confirmed the correlation of UIP pattern with 
      p-ANCA-positivity and a diagnosis of ILD before AAV, also when adjusted for age 
      and sex. CONCLUSIONS: Our study confirms that UIP is a frequent pattern of lung 
      disease in AAVILD patients. Our results also suggest that ILD can represent an 
      early complication of AAV but also occur in the course of the disease, suggesting 
      the need of a careful evaluation by both pulmonologist and rheumatologist to 
      achieve an early diagnosis. Further prospective studies are needed to define ILD 
      prevalence and evolution in AAV patients.
FAU - Manfredi, Andreina
AU  - Manfredi A
AD  - Rheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of 
      Modena and Reggio Emilia, Modena, Italy. andreina.manfredi@gmail.com.
FAU - Cassone, Giulia
AU  - Cassone G
AD  - Rheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of 
      Modena and Reggio Emilia, Modena, and Clinical and Experimental Medicine, PhD 
      Program, University of Modena and Reggio Emilia, Modena, Italy.
FAU - Izzo, Raffaella
AU  - Izzo R
AD  - Rheumatology Unit, Department of Clinical Internal, Anaesthesiologic and 
      Cardiovascular Sciences, Sapienza University of Rome, Italy.
FAU - Dallagiacoma, Gloria
AU  - Dallagiacoma G
AD  - Department of Rheumatology, Hospital of Bruneck (ASAA-SABES), Italy.
FAU - Felicetti, Mara
AU  - Felicetti M
AD  - Operative Unit of Rheumatology, Department of Medicine DIMED, University of 
      Padova, and Rheumatology Unit, Santa Chiara Hospital, Trento, Italy.
FAU - Cariddi, Adriana
AU  - Cariddi A
AD  - Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San 
      Raffaele Hospital & Vita-Salute San Raffaele University, Milano, Italy.
FAU - Berti, Alvise
AU  - Berti A
AD  - Rheumatology Unit, Santa Chiara Hospital, Trento, Italy.
FAU - Giollo, Alessandro
AU  - Giollo A
AD  - Rheumatology Section, Department of Medicine, University of Verona, and Operative 
      Unit of Rheumatology, Department of Medicine DIMED, University of Padova, Italy.
FAU - Nannini, Carlotta
AU  - Nannini C
AD  - Division of Rheumatology, Prato Hospital, Prato, Italy.
FAU - Bettio, Silvano
AU  - Bettio S
AD  - General Medicine Unit 1, Regional Centre for Rare Immunological and 
      Rheumatological Diseases, Ca' Foncello, University Hospital of Treviso, Italy.
FAU - Monti, Sara
AU  - Monti S
AD  - Department of Rheumatology, IRCCS Policlinico S. Matteo Fondazione, University of 
      Pavia, Italy.
FAU - Conticini, Edoardo
AU  - Conticini E
AD  - Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University 
      of Siena, Italy.
FAU - Govoni, Marcello
AU  - Govoni M
AD  - Rheumatology Unit, S. Anna Hospital (AZOU) Ferrara, Department of Medical 
      Sciences, University of Ferrara, Italy.
FAU - Quartuccio, Luca
AU  - Quartuccio L
AD  - Rheumatology Clinic, Department of Medicine, University of Udine, ASU FC, Udine, 
      Italy.
FAU - Argolini, Lorenza Maria
AU  - Argolini LM
AD  - Division of Rheumatology, ASST Gaetano Pini, Milan, Italy.
FAU - Kaleci, Shaniko
AU  - Kaleci S
AD  - Department of Surgical, Medical, Dental and Morphological Sciences related to 
      Transplant, Oncology and Regenerative Medicine, Modena, Italy.
FAU - Emmi, Giacomo
AU  - Emmi G
AD  - Department of Experimental and Clinical Medicine, University of Firenze, Italy.
FAU - Dejaco, Christian
AU  - Dejaco C
AD  - Department of Rheumatology, Hospital of Bruneck (ASAA-SABES), Italy, and 
      Department of Rheumatology, Medical University Graz, Austria.
FAU - Padoan, Roberto
AU  - Padoan R
AD  - Operative Unit of Rheumatology, Department of Medicine DIMED, University of 
      Padova, Italy.
FAU - Dagna, Lorenzo
AU  - Dagna L
AD  - Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San 
      Raffaele Hospital & Vita-Salute San Raffaele University, Milano, Italy.
FAU - Rossini, Maurizio
AU  - Rossini M
AD  - Rheumatology Section, Department of Medicine, University of Verona, Italy.
FAU - Cantini, Fabrizio
AU  - Cantini F
AD  - Division of Rheumatology, Prato Hospital, Prato, Italy.
FAU - Montecucco, Carlomaurizio
AU  - Montecucco C
AD  - Department of Rheumatology, IRCCS Policlinico S. Matteo Fondazione, University of 
      Pavia, Italy.
FAU - Frediani, Bruno
AU  - Frediani B
AD  - Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University 
      of Siena, Italy.
FAU - De Vita, Salvatore
AU  - De Vita S
AD  - Rheumatology Clinic, Department of Medicine, University of Udine, ASU FC, Udine, 
      Italy.
FAU - Caporali, Roberto
AU  - Caporali R
AD  - Division of Rheumatology, ASST Gaetano Pini, Milan, Italy.
FAU - Muratore, Francesco
AU  - Muratore F
AD  - Rheumatology Unit, IRCCS Arcispedale Santa Maria Nuova, Azienda Unita Sanitaria 
      Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
FAU - Sebastiani, Marco
AU  - Sebastiani M
AD  - Rheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of 
      Modena and Reggio Emilia, Modena, Italy.
FAU - Salvarani, Carlo
AU  - Salvarani C
AD  - Rheumatology Unit, Azienda Ospedaliera Policlinico di Modena, University of 
      Modena and Reggio Emilia, Modena, and Rheumatology Unit, IRCCS Arcispedale Santa 
      Maria Nuova, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, Reggio 
      Emilia, Italy.
CN  - Study Group of the Italian Society for Rheumatology (SIR)
LA  - eng
PT  - Journal Article
DEP - 20221006
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - EC 3.4.21.76 (Myeloblastin)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Humans
MH  - *Microscopic Polyangiitis/complications/diagnostic imaging/epidemiology
MH  - *Granulomatosis with Polyangiitis/complications/diagnostic imaging/epidemiology
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - *Rheumatology
MH  - Cross-Sectional Studies
MH  - *Lung Diseases, Interstitial/diagnostic imaging/epidemiology/etiology
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications
MH  - Myeloblastin
MH  - Demography
MH  - Peroxidase
FIR - Schiavon, Franco
IR  - Schiavon F
FIR - Marasco, Emiliano
IR  - Marasco E
FIR - Gattamelata, Angelica
IR  - Gattamelata A
FIR - Bortolotti, Roberto
IR  - Bortolotti R
FIR - Malandrino, Danilo
IR  - Malandrino D
FIR - Maranini, Beatrice
IR  - Maranini B
EDAT- 2022/10/07 06:00
MHDA- 2023/04/20 06:41
CRDT- 2022/10/06 10:23
PHST- 2022/04/13 00:00 [received]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2023/04/20 06:41 [medline]
PHST- 2022/10/07 06:00 [pubmed]
PHST- 2022/10/06 10:23 [entrez]
AID - 18659 [pii]
AID - 10.55563/clinexprheumatol/xu4hmh [doi]
PST - ppublish
SO  - Clin Exp Rheumatol. 2023 Apr;41(4):821-828. doi: 
      10.55563/clinexprheumatol/xu4hmh. Epub 2022 Oct 6.