PMID- 36201939 OWN - NLM STAT- MEDLINE DCOM- 20221222 LR - 20221222 IS - 1878-3252 (Electronic) IS - 0946-672X (Linking) VI - 75 DP - 2023 Jan TI - Higher blood selenium level is associated with lower risk of hyperhomocysteinemia in the elderly. PG - 127078 LID - S0946-672X(22)00158-4 [pii] LID - 10.1016/j.jtemb.2022.127078 [doi] AB - BACKGROUND AND AIMS: Earlier studies have reported inconsistent association between selenium (Se) and homocysteine (Hcy) levels, while no evidence could be found from Chinese population. To fill this gap, we investigated the association between blood Se and hyperhomocysteinemia (HHcy) of rural elderly population in China. METHODS: A cross-sectional study on 1823 participants aged 65 and older from four Chinese rural counties was carried out in this study. Whole blood Se and serum Hcy concentrations were measured in fasting blood samples. Analysis of covariance and restricted cubic spline models were used to examine the association between Se and Hcy levels. Logistic regression models were used to evaluate the risk of prevalent HHcy among four Se quartile groups after adjusting for covariates. RESULTS: For this sample, the mean blood Se concentration was 156.34 (74.65) mug/L and the mean serum Hcy concentration was 17.25 (8.42) mumol/L. A significant non-linear relationship was found between blood Se and serum Hcy, the association was inverse when blood Se was less than 97.404 mug/L and greater than 156.919 mug/L. Participants in the top three blood Se quartile groups had significantly lower risk of prevalent HHcy compared with the lowest quartile group. When defined as Hcy> 10 mumol/L, the odds ratios and 95% confidence interval of HHcy were 0.600 (0.390, 0.924), 0.616 (0.398, 0.951) and 0.479 (0.314, 0.732) for Q2, Q3, and Q4 Se quartile groups compared with the Q1 group, respectively. When defined as Hcy>/= 15 mumol/L, the odds ratios and 95% confidence interval of HHcy were 0.833 (0.633, 1.098) and 0.827 (0.626, 1.092), 0.647 (0.489, 0.857) for Q2, Q3, and Q4 Se quartile groups compared with Q1 group. CONCLUSIONS: Our findings suggest that higher blood Se level could be a protective factor for HHcy in the elderly. CI - Copyright (c) 2022 Elsevier GmbH. All rights reserved. FAU - Wang, Ting AU - Wang T AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China; School of Public Health, Guizhou Medical University, Guiyang 550025, China. FAU - Su, Liqin AU - Su L AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Electronic address: suliqin@nieh.chinacdc.cn. FAU - Chen, Xi AU - Chen X AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Wang, Sisi AU - Wang S AD - Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China. FAU - Han, Xu AU - Han X AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Cheng, Yibin AU - Cheng Y AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Lin, Shaobin AU - Lin S AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Ding, Liang AU - Ding L AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Liu, Jingyi AU - Liu J AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Chen, Chen AU - Chen C AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Unverzagt, Frederick W AU - Unverzagt FW AD - Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA. FAU - Hake, Ann M AU - Hake AM AD - Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. FAU - Jin, Yinlong AU - Jin Y AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Gao, Sujuan AU - Gao S AD - Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202-2872, USA. LA - eng PT - Journal Article DEP - 20220929 PL - Germany TA - J Trace Elem Med Biol JT - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JID - 9508274 RN - H6241UJ22B (Selenium) SB - IM MH - Aged MH - Humans MH - China/epidemiology MH - Cross-Sectional Studies MH - *Selenium OTO - NOTNLM OT - Blood selenium OT - Elderly Chinese OT - Homocysteine OT - Hyperhomocysteinemia OT - Risk assessment COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/10/07 06:00 MHDA- 2022/12/15 06:00 CRDT- 2022/10/06 18:20 PHST- 2022/05/17 00:00 [received] PHST- 2022/07/09 00:00 [revised] PHST- 2022/09/12 00:00 [accepted] PHST- 2022/10/07 06:00 [pubmed] PHST- 2022/12/15 06:00 [medline] PHST- 2022/10/06 18:20 [entrez] AID - S0946-672X(22)00158-4 [pii] AID - 10.1016/j.jtemb.2022.127078 [doi] PST - ppublish SO - J Trace Elem Med Biol. 2023 Jan;75:127078. doi: 10.1016/j.jtemb.2022.127078. Epub 2022 Sep 29.