PMID- 36202321
OWN - NLM
STAT- MEDLINE
DCOM- 20230703
LR  - 20230703
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 42
DP  - 2023 Jun
TI  - Effects of photodynamic therapy on Streptococcus mutans and enamel 
      remineralization of multifunctional TiO(2)-HAP composite nanomaterials.
PG  - 103141
LID - S1572-1000(22)00427-6 [pii]
LID - 10.1016/j.pdpdt.2022.103141 [doi]
AB  - BACKGROUND: As photosensitizer and photocatalyst, titanium dioxide (TiO(2)) can 
      produce a photodynamic reaction for antibacterial treatment. This study aims to 
      explore a Titanium dioxide/nano-hydroxyapatite (TiO(2)-HAP) composite combined 
      with the dental curing lamp (385-515 nm) in clinical which could inhibit the 
      dental plaque biofilm formed by Streptococcus mutans (S. mutans) and promote the 
      enamel surface remineralization simultaneously. METHODS: X-ray Diffraction (XRD) 
      and high resolution transmission electron microscope (HRTEM) were used to detect 
      the characterization of TiO(2)-HAP composite nanomaterials. Photodynamic 
      properties of TiO(2)-HAP were detected by Diffuse reflectance spectrum (DRS) and 
      fluorescence spectroscopy. Bacterial growth was measured by reading the 
      absorbance of bacterial cultures and confocal microscope was used to observe the 
      biofilm removal ability of nanomaterials. The ability of TiO(2)-HAP to promote 
      enamel remineralization was measured by Scanning electron microscope (SEM). 
      RESULTS: The OD 600 of S. mutans was 0.76 in the control group and 0.13 in group 
      of TiO(2)-HAP with exposure to light-emitting diode (LED) (150 mW/cm(2)) for 
      5 min, suggesting its sustained antibacterial potency and inhibition of the 
      metabolic activity of dental plaque microcosm biofilm. Also, the release of 
      calcium and phosphorus ions in TiO(2)-HAP can promote enamel mineralization 
      simultaneously. After 15 days of remineralization, the Ca/P ratio of 
      demineralized enamel surface increased from 1.28 to 1.67, which was similar to 
      that of normal enamel. CONCLUSIONS: The TiO(2)-HAP exhibit a promising 
      anti-bacterial activity and remineralization capacity which can prevent the 
      occurrence of caries to the greatest extent and promote the biomimetic 
      mineralization of dental tissues.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wang, Ranxu
AU  - Wang R
AD  - The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 
      150001, China.
FAU - Jia, Conghui
AU  - Jia C
AD  - The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 
      150001, China.
FAU - Zheng, Nannan
AU  - Zheng N
AD  - School of Life Science and Technology, Key Laboratory of Micro-systems and 
      Micro-structures Manufacturing Ministry of Education, Micro/Nano Technology 
      Research Center, Harbin Institute of Technology, Harbin 150080, China.
FAU - Liu, Shujuan
AU  - Liu S
AD  - School of Materials Science and Engineering, Harbin Institute of Technology, 
      Harbin 150001, PR China.
FAU - Qi, Zhilin
AU  - Qi Z
AD  - School of Life Science and Technology, Key Laboratory of Micro-systems and 
      Micro-structures Manufacturing Ministry of Education, Micro/Nano Technology 
      Research Center, Harbin Institute of Technology, Harbin 150080, China.
FAU - Wang, Ruiwen
AU  - Wang R
AD  - Material Science and Engineering college, Northeast Forestry University, Harbin, 
      Heilongjiang 150080, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - School of Life Science and Technology, Key Laboratory of Micro-systems and 
      Micro-structures Manufacturing Ministry of Education, Micro/Nano Technology 
      Research Center, Harbin Institute of Technology, Harbin 150080, China.
FAU - Niu, Yumei
AU  - Niu Y
AD  - The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 
      150001, China. Electronic address: niuym@hrbmu.edu.cn.
FAU - Pan, Shuang
AU  - Pan S
AD  - The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 
      150001, China. Electronic address: panshuang@hrbmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20221003
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 0 (Photosensitizing Agents)
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Humans
MH  - *Photochemotherapy/methods
MH  - Photosensitizing Agents/pharmacology
MH  - Streptococcus mutans
MH  - Tooth Remineralization/methods
MH  - *Dental Plaque
MH  - *Nanostructures
MH  - Anti-Bacterial Agents/pharmacology
MH  - Biofilms
MH  - *Dental Caries/drug therapy
OTO - NOTNLM
OT  - Anti-biofilm
OT  - Dental caries
OT  - Dental materials
OT  - Photodynamic Therapy
OT  - Remineralization
EDAT- 2022/10/07 06:00
MHDA- 2023/07/03 06:41
CRDT- 2022/10/06 19:25
PHST- 2022/07/20 00:00 [received]
PHST- 2022/09/05 00:00 [revised]
PHST- 2022/09/29 00:00 [accepted]
PHST- 2023/07/03 06:41 [medline]
PHST- 2022/10/07 06:00 [pubmed]
PHST- 2022/10/06 19:25 [entrez]
AID - S1572-1000(22)00427-6 [pii]
AID - 10.1016/j.pdpdt.2022.103141 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Jun;42:103141. doi: 
      10.1016/j.pdpdt.2022.103141. Epub 2022 Oct 3.