PMID- 36203374
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20230105
IS  - 1744-8417 (Electronic)
IS  - 1744-6651 (Linking)
VI  - 17
IP  - 6
DP  - 2022 Nov
TI  - Renal insulin resistance in type 2 diabetes mellitus and progression of chronic 
      kidney disease: potential pathogenic mechanisms.
PG  - 523-532
LID - 10.1080/17446651.2022.2131534 [doi]
AB  - INTRODUCTION: A bidirectional association exists between insulin resistance (IR) 
      and chronic kidney disease (CKD) in Type 2 Diabetes Mellitus (T2DM). Baseline 
      measures of IR are predictive of CKD progression, and uremia in progressive CKD 
      is itself, in turn, associated with a worsening of IR. Pre-clinical research 
      reveals that intrinsic IR in glomerular podocytes and the renal tubule may serve 
      as a pathogenic driver of CKD in T2DM. AREAS COVERED: The present manuscript 
      takes as its point of departure, the recently identified prognostic utility of 
      severe insulin resistance as a predictor of CKD in T2DM. Findings from a series 
      of studies describing the association of IR with pathological alterations in both 
      established, and less commonly assessed dynamic measures of renal impairment are 
      discussed. Drawing upon the pre-clinical mechanistic evidence base, the cellular 
      and molecular basis of intrinsic renal IR as a promoter of CKD is considered. 
      EXPERT OPINION: Measurement of insulin sensitivity may add value to profiling of 
      renal risk in T2DM. Rational selection of therapeutic strategies targeting the 
      enhancement of insulin sensitivity merits special attention regarding the 
      personalized management of CKD in insulin resistance predominant T2DM.
FAU - Alqallaf, Alrataj
AU  - Alqallaf A
AD  - Diabetes Complications Research Centre, Conway Institute of Biomolecular and 
      Biomedical Research, School of Medicine, University College Dublin, Dublin, 
      Ireland.
FAU - Swan, Patrick
AU  - Swan P
AD  - Diabetes Complications Research Centre, Conway Institute of Biomolecular and 
      Biomedical Research, School of Medicine, University College Dublin, Dublin, 
      Ireland.
FAU - Docherty, Neil G
AU  - Docherty NG
AUID- ORCID: 0000-0002-0961-2607
AD  - Diabetes Complications Research Centre, Conway Institute of Biomolecular and 
      Biomedical Research, School of Medicine, University College Dublin, Dublin, 
      Ireland.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221006
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
SB  - IM
MH  - Humans
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy
MH  - *Renal Insufficiency, Chronic/complications
OTO - NOTNLM
OT  - CKD
OT  - Insulin
OT  - diabetes
OT  - kidney
OT  - obesity
OT  - podocyte
OT  - tubular epithelium
EDAT- 2022/10/08 06:00
MHDA- 2022/12/03 06:00
CRDT- 2022/10/07 01:53
PHST- 2022/10/08 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/10/07 01:53 [entrez]
AID - 10.1080/17446651.2022.2131534 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2022 Nov;17(6):523-532. doi: 
      10.1080/17446651.2022.2131534. Epub 2022 Oct 6.